“…Many natural compounds or macromolecules have been adopted to form chiral recognizable sites, such as amino acids [10] , cholesterols [11] , peptides [12,13] , sugars [14][15][16] , and celluloses [17] derivatives. Among them, L-amino acids and their derivatives are widely used because of their diversified structures, low costs, comprehensive applicability and feasibility [18,19] . Microgels based on poly(N-isopropylacrylamide) (PNIPAM), a classic thermosensitive material, have attracted a lot of attentions due to their great potential in numerous applications, e.g., tissue engineering, drug delivery and bionanotechnology [20,21] .…”