Poly(ε‐caprolactone)‐graft‐poly(2‐(dimethylamino)ethyl methacrylate) Amphiphilic Copolymers Prepared via a Combination of ROP and ATRP: Synthesis, Characterization, and Self‐Assembly Behavior

Abstract

Poly(ε‐caprolactone)‐graft‐poly(2‐(dimethylamino) ethyl methacrylate) (PCL‐g‐PDMAEMAs), a kind of amphiphilic graft copolymer, was prepared by combination of ROP and ATRP. The FTIR, 1H NMR, and GPC results indicate that well‐defined polymers with controlled graft density and length of side chain were successfully synthesized. We prepared PCL‐g‐PDMAEMA nanoparticles by employing a nanoprecipitation technique. The pH‐ and thermosensitive properties of PCL‐g‐PDMAEMA nanoparticles were investigated by 1H NMR, TEM, and DLS. It was found that the nanoparticles with an average size of 120 nm presented core–shell structure in aqueous dispersion. Furthermore, the nanoparticles are sensitive to temperature in base while not in an acidic environment.magnified image

Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier

“…γ-(2-Bromo-2-methylpropionate)-ε-caprolactone (BMPCL) was synthesized as reported previously [23,27,28]. ε-Caprolactone (Aldrich) was dried over calcium hydride for 48 h at room temperature and distilled under reduced pressure.…”

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

“…mPEG-PCL-g-PDMAEMA (PECD) and mPEG-P(CL-co-DLLA)-g-PDMAEMA (PECLD) were synthesized by combining ring-opening polymerization and ATRP polymerization as described before (Scheme S1) [36]. Macroinitiator mPEG-P(CL-co-BMPCL) (PECB) and mPEG-P(CL-co-DLLA-co-BMPCL) (PECLB) were respectively prepared of caprolactone and BMPCL, or caprolactone, D,L-lactide and BMPCL by ring-opening polymerization using mPEG as the initiator and Sn(Oct) 2 as a catalyst.…”

Novel amphiphilic temperature responsive graft copolymers PCL-g-P(MEO2MA-co-OEGMA) via a combination of ROP and ATRP: synthesis, characterization, and sol-gel transition

“…According to the literatures [34][35][36][37][38], functional PCL have been widely reported which prepared by homopolymerization or copolymerization with ε-caprolactone (CL) and ε-caprolactone derivatives. They allowed the active group to attach on the PCL side groups, which could introduce side-chain of different properties to construct functional graft copolymers to improve its insufficient, such as mPEG-b-(PCL-g-PMAA) [35], PCL-g-PDMAEMA [36,37], PCL-g-PHEMA [38], PCL-g-PMMA [39], PCL-g-PEG [34,40]. PEG or PEO grafted copolymers can offer more versatility and latitude as the hydrophilicity of the polymers can be modulated by both the length and graft numbers of hydrophilic segment, whereas the responsive temperature of graft copolymers could hardly be modulated.…”