Poly(l-lactic acid)/alkali lignin composites: properties, biocompatibility, cytotoxicity and antimicrobial behavior

Bužarovska, Aleksandra; Blazevska-Gilev, Jadranka; Pérez-Martnez, B. T.; Balahura, Liliana Roxana; Pîrcălăbioru, Grațiela Grădișteanu; Dinescu, Sorina; Costache, Marieta

doi:10.1007/s10853-021-06185-6

Cited by 23 publications

(12 citation statements)

References 46 publications

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“…The bands at 2995 cm −1 and 1075 cm −1 were assigned to the stretching of the -CH 3 and C-O bonds, respectively [ 49 ]. The hydroxyl surface groups of lignin have a strong tendency to form hydrogen bonds with the carbonyl group of PLA [ 25 , 27 , 29 ]. Obviously, we refer to free carbonyls (non-bound within other interactions).…”

Section: Resultsmentioning

confidence: 99%

“…As proposed by Tabi et al [ 71 ], the first melting peak may originate from the simultaneous α crystal melting, produced upon annealing, and the α′ to α recrystallization; while the second melting peak signifies the melting of the α crystal form produced from the α′ to α recrystallization process. Although it is hard to precisely define the crystal content of composites [ 3 , 29 ], the synthesized PLA-L/NL composites present a similar profile to neat PLA. This suggests that the type (α, α′ crystal forms) and the quality of PLA crystals is preserved in the composites, independently from the particle size and the content of the lignin filler.…”

Section: Resultsmentioning

confidence: 99%

“…Solvent casting in a poly(vinyl alcohol) aqueous solution was used to prepare PLA-L films that exhibited very good antimicrobial properties and a shorter biodegradability time in soil. Likewise, Buzarovska et al used solvent casting in dioxane solvent to prepare 120 ± 10 μm thick PLA–L films with low molecular mass alkali lignin (1–10 wt%) [ 29 ]. The films showed weaker mechanical properties compared to neat PLA, even at 1 wt% lignin loading.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Micro- and Nano-Lignin on the Thermal, Mechanical, and Antioxidant Properties of Biobased PLA–Lignin Composite Films

et al. 2022

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Bio-based poly(lactic acid) (PLA) composite films were produced using unmodified soda micro- or nano-lignin as a green filler at four different contents, between 0.5 wt% and 5 wt%. The PLA–lignin composite polymers were synthesized by solvent casting to prepare a masterbatch, followed by melt mixing. The composites were then converted into films, to evaluate the effect of lignin content and size on their physicochemical and mechanical properties. Differential scanning calorimetry (DSC), supported by polarized light microscopy (PLM), infrared spectroscopy (FTIR-ATR), X-ray diffraction (XRD), and transmission electron microscopy (TEM) were employed to investigate the PLA crystallization and the interactions with Lignin (L) and Nanolignin (NL). The presence of both fillers (L and NL) had a negligible effect on the glass transition temperature (chain diffusion). However, it resulted in suppression of the corresponding change in heat capacity. This was indicative of a partial immobilization of the PLA chains on the lignin entities, due to interfacial interactions, which was slightly stronger in the case of NL. Lignin was also found to facilitate crystallization, in terms of nucleation; whereas, this was not clear in the crystalline fraction. The addition of L and NL led to systematically larger crystallites compared with neat PLA, which, combined with the higher melting temperature, provided indications of a denser crystal structure in the composites. The mechanical, optical, antioxidant, and surface properties of the composite films were also investigated. The tensile strength and Young’s modulus were improved by the addition of L and especially NL. The UV-blocking and antioxidant properties of the composite films were also enhanced, especially at higher filler contents. Importantly, the PLA–NL composite films constantly outperformed their PLA–L counterparts, due to the finer dispersion of NL in the PLA matrix, as verified by the TEM micrographs. These results suggest that bio-based and biodegradable PLA films filled with L, and particularly NL, can be employed as competitive and green alternatives in the food packaging industry.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Micro- and Nano-Lignin on the Thermal, Mechanical, and Antioxidant Properties of Biobased PLA–Lignin Composite Films

et al. 2022

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“…Concerning the PLA counterpart, the L-/D-lactide isomers ratio and the macromolecular extent also play a crucial role in the degree of crystallinity [18]. To overcome the limitations attributed to crystallinity and tune the relative properties desired for specific applications, scientific research has been directed towards the synthesis of PLA nanocomposites with several types of nanoscale fillers, including metals, metal oxides, carbon nanotubes and several other clays [10,[19][20][21][22][23][24][25][26][27][28]. In general, nano-sized fillers are proved to be excellent agents to boost several properties of polymers, including thermal stability, degradation efficiency, optical, mechanical and permeation properties [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Thermal Stability and Decomposition Mechanism of PLA Nanocomposites with Kraft Lignin and Tannin

et al. 2021

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Packaging applications cover approximately 40% of the total plastics production, whereas food packaging possesses a high proportion within this context. Due to several environmental concerns, petroleum-based polymers have been shifted to their biobased counterparts. Poly(lactic acid) (PLA) has been proved the most dynamic biobased candidate as a substitute of the conventional polymers. Despite its numerous merits, PLA exhibits some limitations, and thus reinforcing agents are commonly investigated as fillers to ameliorate several characteristics. In the present study, two series of PLA-based nanocomposites filled with biobased kraft-lignin (KL) and tannin (T) in different contents were prepared. A melt–extrusion method was pursued for nanocomposites preparation. The thermal stability of the prepared nanocomposites was examined by Thermogravimetric Analysis, while thermal degradation kinetics was applied to deepen this process. Pyrolysis–Gas Chromatography/Mass Spectrometry was employed to provide more details of the degradation process of PLA filled with the two polyphenolic fillers. It was found that the PLA/lignin nanocomposites show better thermostability than neat PLA, while tannin filler has a small catalytic effect that can reduce the thermal stability of PLA. The calculated Eα value of PLA-T nanocomposite was lower than that of PLA-KL resulting in a substantially higher decomposition rate constant, which accelerate the thermal degradation.

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“…Saudi et al had also reported electospun poly (glycerol sebacate)-poly(vinyl alcohol) fibers with lignin had promoted the neural cell proliferation and differentiation [ 26 ]. The addition of lignin in the blend induces anti-oxidative properties that would facilitate cell viability [ 27 , 28 ]. The low cell viability at higher lignin concentrations is possibly due to the inhibition from lignin itself pass the ideal range.…”

Section: Resultsmentioning

confidence: 99%

PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment

et al. 2022

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Background Osteoarthritis (OA) is common musculoskeletal disorders associated with overgeneration of free radicals, and it causes joint pain, inflammation, and cartilage degradation. Lignin as a natural antioxidant biopolymer has shown its great potential for biomedical applications. In this work, we developed a series of lignin-based nanofibers as antioxidative scaffolds for cartilage tissue engineering. Results The nanofibers were engineered by grafting poly(lactic acid) (PLA) into lignin via ring-opening polymerization and followed by electrospinning. Varying the lignin content in the system was able to adjust the physiochemical properties of the resulting nanofibers, including fiber diameters, mechanical and viscoelastic properties, and antioxidant activity. In vitro study demonstrated that the PLA-lignin nanofibers could protect bone marrow-derived mesenchymal stem/stromal cells (BMSCs) from oxidative stress and promote the chondrogenic differentiation. Moreover, the animal study showed that the lignin nanofibers could promote cartilage regeneration and repair cartilage defects within 6 weeks of implantation. Conclusion Our study indicated that lignin-based nanofibers could serve as an antioxidant tissue engineering scaffold and facilitate the cartilage regrowth for OA treatment. Graphical Abstract

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Poly(l-lactic acid)/alkali lignin composites: properties, biocompatibility, cytotoxicity and antimicrobial behavior

Cited by 23 publications

References 46 publications

Effect of Micro- and Nano-Lignin on the Thermal, Mechanical, and Antioxidant Properties of Biobased PLA–Lignin Composite Films

Effect of Micro- and Nano-Lignin on the Thermal, Mechanical, and Antioxidant Properties of Biobased PLA–Lignin Composite Films

Thermal Stability and Decomposition Mechanism of PLA Nanocomposites with Kraft Lignin and Tannin

PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment

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