Poly-l-Lactic Acid for Nonfacial Skin Laxity

Mazzuco, Rosemarie; DalʼForno, Taciana; Hexsel, Dóris

doi:10.1097/dss.0000000000002390

Cited by 10 publications

(24 citation statements)

References 2 publications

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“…Good results with PLLA treatment were reported in case reports, retrospective reviews, clinical studies, 97 and clinical practice, for buttock augmentation and reshaping/contouring 22 , 92 , 98 , 99 to treat skin laxity/flaccidity, 92 , 94–96 cellulite, 92–97 scars and striae appearance 94 providing gluteal augmentation, cellulite appearance improvement and natural looking-effect ( Table 2 ). The first published cases showed for 2 subjects that PLLA is an effective option giving a natural looking effect for gluteal augmentation and the reduction of cellulite appearance.…”

Section: Plla and Buttocksmentioning

confidence: 97%

“…PLLA is reconstituted in 10 to 20 mL of sterile water plus lidocaine 2h, 98 24 h, 92 , 96 , 99 48h 95 , 97 to 72h 94 or 96h 93 , 97 before administration ( Table 2 ). For volume augmentation treatments, a more concentrated preparation of PLLA can be used (10 mL per vial) and a more diluted one to treat cellulite (15 mL per vial).…”

Section: Plla and Buttocksmentioning

confidence: 99%

“… 98 Depending on the patients’ demand, the number of treatments varies from 1 to 11, 4–24 weeks apart. 93 , 94 , 96–98 The product should be injected preferentially in the superior and lateral quadrants of the buttocks avoiding the “danger triangle”, 73 with a linear threading or fanning technique using a cannula or a needle. 27 , 73 , 98 A recent publication reported a description of PLLA administration in the buttocks.…”

Section: Plla and Buttocksmentioning

confidence: 99%

“… 12 , 103 , 104 PLLA was investigated in this body area, but data are also limited ( Table 3 ). 26 , 27 , 94 , 98 , 101 …”

Section: Plla and Abdomenmentioning

confidence: 99%

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Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Christen¹

2022

CCID

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The number of aesthetic procedures performed worldwide continues to grow together with an increase in the population seeking the restoration or preservation of a youthful appearance. Requests for non-surgical body rejuvenation are increasing. Patients are looking for safe and effective minimally invasive aesthetic procedures. Soft-tissue dermal fillers can meet these expectations. Based on the beneficial outcomes of these treatments in many facial areas, a new trend is developing to target body areas. Different dermal fillers are available and include collagen stimulators initially developed to restore facial volume. Furthermore, they are associated with long-lasting efficiency, a high level of patient satisfaction and a good safety profile, with mainly minor adverse events reported. In appropriate conditions of use, they are now used for body rejuvenation in clinical practice. Their use is expanding and allows addressing various issues including volume loss, skin laxity, cellulite, striae distensae and wrinkles. This review focuses on poly-L-lactic acid (PLLA), used in the first collagen stimulator and one of the most investigated in facial and in off-facial body applications. The available published data, although still limited, are presented by body area, neck and chest, buttocks, abdomen, upper arms, thighs, knees, and hands. Key features of the concerned zones and the main clinical signs affecting the body part as well as the injection modalities are provided along with the aesthetic results. This represents the state of the art on which to base further developments necessary for optimal and safe outcomes of treatment with the PLLA-based collagen stimulators and others in this class for body rejuvenation.

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Section: Plla and Buttocksmentioning

confidence: 97%

Section: Plla and Buttocksmentioning

confidence: 99%

Section: Plla and Buttocksmentioning

confidence: 99%

“… 12 , 103 , 104 PLLA was investigated in this body area, but data are also limited ( Table 3 ). 26 , 27 , 94 , 98 , 101 …”

Section: Plla and Abdomenmentioning

confidence: 99%

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Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Christen¹

2022

CCID

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“… 11 , 12 The resulting effect is a decrease in skin laxity and improvement in anatomical contours. 1 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cannula Safety in Injection of Poly-L-Lactic Acid

Nikolis¹,

Avelar²,

Enright³

2021

CCID

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Background and Objective Poly-L-lactic acid (PLLA) has been used in various medical applications for decades, including aesthetic ones. The use of a cannula technique in injecting PLLA has been proposed in order to lower the incidence rate of adverse events (AEs) following treatment. Such AEs include nodule formation, which may occur less frequently by fanning the product with a cannula, thus creating a more uniform product placement compared to that resulting from the use of a needle. Currently, however, there is a lack of comparative research regarding the safety of cannulas versus needles for PLLA injections, as the selection of either remains highly subjective. Therefore, the objective of our study was to investigate the safety of cannula use in the administration of PLLA, in order to report safety outcomes. Materials and Methods A single-center, retrospective chart review was conducted to examine the data of patients who had previously undergone treatment with PLLA in the form of Sculptra ® Aesthetic™ in the face and/or neck regions. Twenty-seven subject charts met eligibility. Descriptive data regarding treatment and follow-up visits were collected and analyzed. Results A total of seven AEs resulted from eighty-two treatment sessions (8.54%), with 6/27 patients having experienced at least one AE (22.22%). Mild bruising was the most commonly reported AE (57.14%). The majority of the AEs were mild and transient in nature, with one moderate AE being a nodule that was possibly related to a concomitant treatment. All AEs were resolved with follow-up care. Conclusion Mild AEs such as bruising, swelling and pain should be expected following the use of a cannula for PLLA injections. However, the incidence rates of AEs following treatment can remain low if proper product preparation and treatment techniques are utilized.

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