Poly(lactic acid) as Biomaterial for Cardiovascular Devices and Tissue Engineering Applications

Hadasha, Waled; Bezuidenhout, Deon

doi:10.1007/12_2017_27

Cited by 25 publications

(16 citation statements)

References 139 publications

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“…PLLA and PLGA have been considered as two of the most potent candidates for biomedical applications [ 31 , 32 ]. Due to their cytocompatibility, biodegradable properties, non-toxicity, and mechanical features, they are extensively used to fabricate tissue engineering scaffolds [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Gazińska

Krokos

Kobielarz

et al. 2020

IJMS

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Novel biocomposites of poly(L-lactide) (PLLA) and poly(l-lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of hydroxyapatite (HAP) was modified with polyethylene glycol by using l-lysine as a linker molecule. The modification strategy fulfilled two important goals: improvement of the adhesion between the HAP surface and PLLA and PLLGA matrices, and enhancement of the osteological bioactivity of the composites. The surface modifications of HAP were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), TGA, and elemental composition analysis. The influence of hydroxyapatite surface functionalization on the thermal and in vitro biological properties of PLLA- and PLLGA-based composites was investigated. Due to HAP modification with polyethylene glycol, the glass transition temperature of PLLA was reduced by about 24.5 °C, and melt and cold crystallization abilities were significantly improved. These achievements were scored based on respective shifting of onset of melt and cold crystallization temperatures and 1.6 times higher melt crystallization enthalpy compared with neat PLLA. The results showed that the surface-modified HAP particles were multifunctional and can act as nucleating agents, plasticizers, and bioactive moieties. Moreover, due to the presented surface modification of HAP, the crystallinity degree of PLLA and PLLGA and the polymorphic form of PLLA, the most important factors affecting mechanical properties and degradation behaviors, can be controlled.

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Section: Resultsmentioning

confidence: 99%

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Gazińska

Krokos

Kobielarz

et al. 2020

IJMS

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“…PDLA is a crystalline material and PLLA is a semicrystalline material, while PDLLA and meso-poly(lactic acid) are amorphous materials. 113 Among the four forms of lactides, the semi-crystalline PLLA has been widely studied for cardiac tissue applications because of its biocompatibility, biodegradability, nontoxicity, and good mechanical integrity. 94,95 However, the long degradable time of PLLA is a main drawback for its use in cardiac tissue applications.…”

Section: Poly(lactic Acid)mentioning

confidence: 99%

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

101

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Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

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“…One of the most attractive candidates is polylactide, because its production is based on natural resources and because its properties can be varied over a broad range. This broad variation can be achieved via different chain lengths, different topologies, different stereosequences, by copolymerization with various comonomers and blending with another polymer 1–8 . Almost all homo‐ and copolymers of lactic acid are produced by ring‐opening polymerization (ROP) of lactide, and for their technical production (by polymerization in bulk) tin(II) 2‐ethylhexanoate (SnOct 2 ) is the most widely used catalyst 9–11 .…”

Section: Introductionmentioning

confidence: 99%

ROP of L‐lactide and ε‐caprolactone catalyzed by tin(ii) and tin(iv) acetates–switching from COOH terminated linear chains to cycles

Kricheldorf

Weidner

2021

Journal of Polymer Science

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The catalytic potential of tin(II)acetate, tin(IV)acetate, dibutyltin‐bis‐acetate and dioctyl tin‐bis‐acetate was compared based on polymerizations of L‐lactide conducted in bulk at 160 or 130°C. With SnAc2 low‐Lac/Cat ratios (15/1–50/1) were studied and linear chains having one acetate and one carboxyl end group almost free of cyclics were obtained. Higher monomer/catalyst ratios and lower temperatures favored formation of cycles that reached weight average molecular weights (Mw's) between 100,000 and 2,500,000. SnAc4 yielded mixtures of cycles and linear species under all reaction conditions. Dibutyltin‐ and dioctyl tin bis‐acetate yielded cyclic polylactides under most reaction conditions with Mw's in the range of 20,000–80,000. Ring‐opening polymerizations performed with ε‐caprolactone showed similar trends, but the formation of COOH‐terminated linear chains was significantly more favored compared to analogous experiments with lactide. The reactivity of the acetate catalysts decreased in the following order: SnAc2 > SnAc4 > Bu2SnAc2 ~ Oct2SnAc2.

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Poly(lactic acid) as Biomaterial for Cardiovascular Devices and Tissue Engineering Applications

Cited by 25 publications

References 139 publications

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

ROP of L‐lactide and ε‐caprolactone catalyzed by tin(ii) and tin(iv) acetates–switching from COOH terminated linear chains to cycles

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