Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure

Yang, Ming; Ouyang, Yaqi; Qin, Yujia; Jia, Changchang; McCoubrey, Laura E.; Basit, Abdul W.; Nie, Yichu; Jia, Yizhen; Liu, Yu; Liu, Dou; Deng, Wenbin; Deng, Yang; Liu, Yang

doi:10.1039/d2nr01846b

Cited by 7 publications

(6 citation statements)

References 32 publications

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Section: Resultssupporting

confidence: 61%

“…In addition, the morphology of the NPs was observed by transmission electron microscopy (TEM), which indicated no considerable structural changes during NaIO 4 oxidation and Tris incubation (Figure 2C). The three NPs were comparable in size and shape to the nifedipine-loaded BNPs (NFDP) obtained in a previous study [26]. Additionally, the encapsulation efficiency of the IDB/NNPs was approximately 51.52%, while those of IDB/BNPs and IDB/Tris-BNPs were approximately 40.95%.…”

Section: Characterization Of Idb/tris-bnpssupporting

confidence: 67%

“…Furthermore, the Tris coating gradually diffused during the penetration process, resulting in the exposure of aldehyde groups in BNPs that could react with amine groups in the basal layer cell membrane protein. The reaction ability between aldehyde groups in BNPs and amine groups has been proven previously [ 26 ]. Thus, the Tris-BNPs exhibited excellent bioadhesivity, as for BNPs, and firmly adhered to the skin, where they were retained longer ( Figure 1 B,C).…”

Section: Introductionmentioning

confidence: 99%

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Microneedle-Assisted Topical Delivery of Idebenone-Loaded Bioadhesive Nanoparticles Protect against UV-Induced Skin Damage

Xie

Ouyang

et al. 2023

Biomedicines

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Ultraviolet (UV) radiation can penetrate the basal layer of the skin and induce profound alterations in the underlying dermal tissues, including skin pigmentation, oxidative stress, photoaging, glycation, and skin cancer. Idebenone (IDB), an effective antioxidant that suppresses melanin biosynthesis and glycation, can protect the skin from UV-induced damage, accounting for its use in commercial anti-aging formulations. Ideally, IDB formulations should retain IDB inside the skin for a sufficient period, despite disturbances such as sweating or swimming. Herein, we present an IDB topical formulation based on Tris (tris(hydroxymethyl)-aminomethane)-modified bioadhesive nanoparticles (Tris-BNPs) and microneedle-assisted delivery. We found that Tris-BNPs loaded with IDB (IDB/Tris-BNPs) effectively reached the basal layer of the skin and were retained for at least 4 days with a slow and continuous drug release profile, unlike non-bioadhesive nanoparticles (NNPs) and bioadhesive nanoparticles (BNPs) of similar sizes (ranging from 120–142 nm) and zeta-potentials (above −20 mV), which experienced a significant reduction in concentration within 24 h. Notably, IDB/Tris-BNPs showed superior performance against UV-induced damage relative to IDB/NNPs and IDB/BNPs. This effect was demonstrated by lower levels of reactive oxygen species and advanced glycation end-products in skin tissues, as well as suppressed melanogenesis. Therefore, the proposed IDB delivery strategy provided long-term protective effects against UV-induced skin damage.

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Section: Resultssupporting

confidence: 61%

Section: Characterization Of Idb/tris-bnpssupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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Microneedle-Assisted Topical Delivery of Idebenone-Loaded Bioadhesive Nanoparticles Protect against UV-Induced Skin Damage

Xie

Ouyang

et al. 2023

Biomedicines

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“…Using the co-precipitation method, SKN could be incorporated into the hydrophobic core of the nanoparticles (SKN/NNP). The oxidative conversion of NNP to BNP was achieved by NaIO 4 treatment, which was reported to have no effect on the particle size and appearance of nanoparticles ( Mai et al, 2022 ). Transmission electronic microscopy (TEM) confirmed the spherical shape of the BNP and SKN/BNP ( Figure 1A ).…”

Section: Resultsmentioning

confidence: 99%

PLA-HPG based coating enhanced anti-biofilm and wound healing of Shikonin in MRSA-infected burn wound

Han

Chen

Liang

et al. 2023

Front. Bioeng. Biotechnol.

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Burn wounds are susceptible to bacterial infections, including Methicillin-resistant Staphylococcus aureus (MRSA), which typically form biofilms and exhibit drug resistance. They also have specific feature of abundant exudate, necessitating frequent drug administration. Shikonin (SKN) has been reported to reverse MRSA drug resistance and possesses anti-biofilm and wound healing properties, however, it suffers from drawbacks of low solubility and instability. In this study, we developed PLA-HPG based bioadhesive nanoparticles SKN/BNP, which demonstrated a drug loading capacity of about 3.6%, and exhibited sustained-release behavior of SKN. The aldehyde groups present on the surface of BNP improved the local adhesion of SKN/BNP both in vitro and in vivo, thereby reducing the frequency of drug dosing in exudate-rich burn wounds. BNP alone enhanced proliferation and migration of the fibroblast, while SKN/BNP promoted fibroblast proliferation and migration as well as angiogenesis. Due to its bioadhesive property, BNP directly interacted with biofilm and enhanced the efficacy of SKN against MRSA biofilm in vitro. In a mouse model of MRSA-infected burn wounds, SKN/BNP demonstrated improved anti-biofilm and wound healing efficiency. Overall, our findings suggest that SKN/BNP holds great promise as a novel and effective treatment option for clinical applications in MRSA-infected burn wounds.

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“…Drug delivery with NPs often also allows for increased functionality and esthetics of the drugs ( Suh et al., 2019 ). Some NPs have been designed to incorporate a bioadhesive quality to increase interactive forces between the material and the tissue or cellular target material, including skin and mucous membranes, thereby increasing the specificity and persistence of the NPs ( Deng et al., 2015 ; Duan et al., 2021a ; Mai et al., 2022 ; Mohideen et al., 2017 ). For inorganic molecule delivery, NPs facilitate targeted delivery and can be engineered for increased bioadhesiveness, which presents several advantages over the currently available formulations targeted toward the skin ( Elsabahy and Wooley, 2013 ; Yu et al., 2022 ), including minimizing accumulation in off-target sites that may lead to adverse effects ( Soppimath et al., 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment

Chang¹,

Yu²,

Saltzman³

et al. 2023

JID Innovations

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Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure

Abstract: Bioadhesive nanoparticles were developed for local drug delivery to esophagus, which elongated drug release time and enhanced esophageal drug exposure, providing significant therapeutic efficacy on achalasia.

Cited by 7 publications

References 32 publications

Microneedle-Assisted Topical Delivery of Idebenone-Loaded Bioadhesive Nanoparticles Protect against UV-Induced Skin Damage

Microneedle-Assisted Topical Delivery of Idebenone-Loaded Bioadhesive Nanoparticles Protect against UV-Induced Skin Damage

PLA-HPG based coating enhanced anti-biofilm and wound healing of Shikonin in MRSA-infected burn wound

Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment

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