2018
DOI: 10.1002/wnan.1516
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Poly(lactic‐co‐glycolic acid) devices: Production and applications for sustained protein delivery

Abstract: Injectable or implantable poly(lactic-co-glycolic acid) (PLGA) devices for the sustained delivery of proteins have been widely studied and utilized to overcome the necessity of repeated administrations for therapeutic proteins due to poor pharmacokinetic profiles of macromolecular therapies. These devices can come in the form of microparticles, implants, or patches depending on the disease state and route of administration. Furthermore, the release rate can be tuned from weeks to months by controlling the poly… Show more

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Cited by 51 publications
(34 citation statements)
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References 199 publications
(227 reference statements)
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“…Cells enzymatically degrade PLGA into monomers that can cause cell death due to their acidic nature [202]. PLGA can be formulated into scaffolds, nano and microparticles, and electrospun fibers [203]. The ability to create biocompatible scaffolds with tunable drug delivery properties makes PLGA an attractive material for stem cell-based tissue engineering.…”
Section: Poly (Lactic-co-glycolic Acid)mentioning
confidence: 99%
“…Cells enzymatically degrade PLGA into monomers that can cause cell death due to their acidic nature [202]. PLGA can be formulated into scaffolds, nano and microparticles, and electrospun fibers [203]. The ability to create biocompatible scaffolds with tunable drug delivery properties makes PLGA an attractive material for stem cell-based tissue engineering.…”
Section: Poly (Lactic-co-glycolic Acid)mentioning
confidence: 99%
“…In the encapsulation of hydrophilic peptides or proteins, drug leakage from the internal water phase to the external water phase is a big challenge [23–27]. Fortunately, LP‐98 shows better encapsulation and drug loading efficiency, which was attributed to the amphiphilicity of lipopeptide.…”
Section: Resultsmentioning
confidence: 99%
“…The relatively high initial burst release of RDV from the gel depot can be directly linked to the fast sol–gel transition of the formulation. The quick gel formation process was driven by the rapid transfer of the water miscible organic solvent NMP from the solution formulation into the aqueous environment with a simultaneous rapid phase separation of PLGA polymer ( Ahmed et al, 2016 , Lee and Pokorski, 2018 ). This is followed by formation of large pores leading to the formation of water accessible channels on the surface and inner core.…”
Section: Discussionmentioning
confidence: 99%