Poly (Lactic-Co-Glycolic) Acid (PLGA) Adjuvant for Immunotherapy

Roopngam, Piyachat Evelyn

doi:10.35248/2593-8509.17.2.113

Cited by 2 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This pre-clinical assessment showed that encapsulation of the HIV p24 antigen with PLA induced a higher IgA titre and a stronger Th1 immune response against HIV infection compared with HIV p24 antigen alone. DNA-based HBV antigen was entrapped with PLGA adjuvant as an HBV vaccine, which was delivered into the murine model [ 265 ]. The immunisation of PLGA adjuvant produced higher antibody titres with a strong humoral immune response in comparison to the HBV vaccine alone [ 265 ].…”

Section: Particulate Adjuvantsmentioning

confidence: 99%

See 1 more Smart Citation

Advances in Infectious Disease Vaccine Adjuvants

et al. 2022

View full text Add to dashboard Cite

Vaccines are one of the most significant medical interventions in the fight against infectious diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the worldwide transmission to eradication levels of infectious diseases, including smallpox, diphtheria, hepatitis, malaria, and influenza. However, the complexity of developing safe and effective vaccines remains a barrier for combating many more infectious diseases. Immune stimulants (or adjuvants) are an indispensable factor in vaccine development, especially for inactivated and subunit-based vaccines due to their decreased immunogenicity compared to whole pathogen vaccines. Adjuvants are widely diverse in structure; however, their overall function in vaccine constructs is the same: to enhance and/or prolong an immunological response. The potential for adverse effects as a result of adjuvant use, though, must be acknowledged and carefully managed. Understanding the specific mechanisms of adjuvant efficacy and safety is a key prerequisite for adjuvant use in vaccination. Therefore, rigorous pre-clinical and clinical research into adjuvant development is essential. Overall, the incorporation of adjuvants allows for greater opportunities in advancing vaccine development and the importance of immune stimulants drives the emergence of novel and more effective adjuvants. This article highlights recent advances in vaccine adjuvant development and provides detailed data from pre-clinical and clinical studies specific to infectious diseases. Future perspectives into vaccine adjuvant development are also highlighted.

show abstract

Section: Particulate Adjuvantsmentioning

confidence: 99%

“…DNA-based HBV antigen was entrapped with PLGA adjuvant as an HBV vaccine, which was delivered into the murine model [ 265 ]. The immunisation of PLGA adjuvant produced higher antibody titres with a strong humoral immune response in comparison to the HBV vaccine alone [ 265 ].…”

Section: Particulate Adjuvantsmentioning

confidence: 99%

Advances in Infectious Disease Vaccine Adjuvants

et al. 2022

View full text Add to dashboard Cite

show abstract

“…), which could contribute to enhancing immune responses. 25,26 The purpose of this study was to design and prepare the polyethylenimine (PEI)-modified CYP-encapsulated PLGA nanoparticles (CYPP-PEI) and determine whether cationic-modified CYPP-PEI nanoparticles could enhance the effect of macrophages in vitro and facilitate the immune responses after immunization with PCV-2 antigen-absorbed nanoparticles in vivo.…”

Section: Introductionmentioning

confidence: 99%

<p>The Immunoenhancement Effects of Polyethylenimine-Modified Chinese Yam Polysaccharide-Encapsulated PLGA Nanoparticles as an Adjuvant</p>

Zhang¹,

Gu²,

Wusiman³

et al. 2020

IJN

View full text Add to dashboard Cite

Background: Poly(lactic-co-glycolic acid) (PLGA) has been extensively applied for sustained drug delivery and vaccine delivery system. However, vaccines delivered by PLGA nanoparticles alone could not effectively activate antigen-presenting cells (APCs) to induce strong immune responses. Purpose: The aim of the present study was to design polyethylenimine (PEI)-modified Chinese yam polysaccharide (CYP)-encapsulated PLGA nanoparticles (CYPP-PEI) as a vaccine delivery system and evaluate the adjuvant activities in vitro and in vivo. Materials and Methods: Cationic-modified nanoparticles exhibited high antigen absorption and could be efficiently taken by APCs to enhance the immune responses. Therefore, PEI-modified CYP-encapsulated PLGA nanoparticles (CYPP-PEI) were prepared. The storage stability and effective adsorption capacity for porcine circovirus-2 (PCV-2) antigen of these antigen-absorbed nanoparticles were measured for one month. Furthermore, the adjuvant activity of CYPP-PEI nanoparticles was evaluated on macrophages in vitro and through immune responses triggered by PCV-2 antigen in vivo. Results: The PCV-2 absorbed CYPP-PEI nanoparticles showed excellent storage stability and high absorption efficiency of PCV-2 antigen. In vitro, CYPP-PEI nanoparticles promoted antigen uptake, enhanced surface molecular expressions of CD80 and CD86, and improved cytokine secretion of TNF-α, IFN-γ, and IL-12p70 in macrophages. After immunization with CYPP-PEI/PCV-2 formulation in mice, the expressions of surface activation markers on dendritic cells which located in draining lymph nodes were increased, such as MHCI, MHCII, and CD80. In addition, CYPP-PEI nanoparticles induced dramatically high PCV-2-specific IgG levels which could last for a long time and stimulated the secretion of subtype antibodies and cytokines. The results showed that CYPP-PEI could induce Th1/Th2 mixed but Th1-biased type immune responses. Conclusion: Polyethylenimine-modified Chinese yam polysaccharide-encapsulated PLGA nanoparticle was a potential vaccine delivery system to trigger strong and persistent immune responses.

show abstract

Poly (Lactic-Co-Glycolic) Acid (PLGA) Adjuvant for Immunotherapy

Cited by 2 publications

References 19 publications

Advances in Infectious Disease Vaccine Adjuvants

Advances in Infectious Disease Vaccine Adjuvants

<p>The Immunoenhancement Effects of Polyethylenimine-Modified Chinese Yam Polysaccharide-Encapsulated PLGA Nanoparticles as an Adjuvant</p>

Contact Info

Product

Resources

About