Poly(lactide-co-glycolide) nanoparticles as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells

Cegnar, Mateja; Premzl, Aleš; Zavašnik-Bergant, Valentina; Kristl, Julijana; Kos, Janko

doi:10.1016/j.yexcr.2004.07.021

Cited by 60 publications

(41 citation statements)

References 30 publications

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“…To date, many types of drug delivery nanosystems have been developed, for example, polymeric nanoparticles of poly(D,L-lactide-coglycolide) (PLGA), liposomes, dendrimers, micelles, and silica nanoparticles. [23][24][25] We have been investigating silica nanocapsules for a controlled release of drugs. We successfully prepared hollow mesoporous silica nanocapsules (HMSNs) with very thin shells in the range of 3-10 nm (Fig.…”

Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

“…[35][36][37][38][39] PLGA is a very good material for generating PLGA nanoparticles, which are biocompatible and degradable with no toxicity. Cegnar et al have investigated the use of PLGA nanoparticles containing cystatin, a potential anticancer drug inhibiting the tumor-associated activity of intracellular cysteine proteases cathepsins, 23 as a carrier system to regress tumor growth, and showed that PLGA nanoparticles are useful for a rapid delivery of protein inhibitors into tumor cells, enabling an effective inhibition of the intracellular proteolysis. McCarthy et al have recently synthesized another new type of a carrier system, that is, PLGA nanoparticles encapsulating the photosensitizer meso-tetraphenylporpholactol.…”

Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

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Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Liu

Miyoshi

Nakamura

2007

Intl Journal of Cancer

567

340

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The diagnosis and treatment of cancer or tumor at the cellular level will be greatly improved with the development of techniques that enable the delivery of analyte probes and therapeutic agents into cells and cellular compartments. Organic and inorganic nanoparticles that interface with biological systems have recently attracted widespread interest in the fields of biology and medicine. The new term nanomedicine has been used recently. Nanoparticles are considered to have the potential as novel intravascular or cellular probes for both diagnostic (imaging) and therapeutic purposes (drug/gene delivery), which is expected to generate innovations and play a critical role in medicine. Target-specific drug/ gene delivery and early diagnosis in cancer treatment is one of the priority research areas in which nanomedicine will play a vital role. Some recent breakthroughs in this field recently also proved this trend. Nanoparticles for drug delivery and imaging have gradually been developed as new modalities for cancer therapy and diagnosis. In this article, we review the significance and recent advances of gene/drug delivery to cancer cells, and the molecular imaging and diagnosis of cancer by targeted functional nanoparticles. ' 2007 Wiley-Liss, Inc.

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Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Liu

Miyoshi

Nakamura

2007

Intl Journal of Cancer

567

340

View full text Add to dashboard Cite

show abstract

“…Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their applications as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging [3][4][5].…”

Section: Cancermentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

El-Karim¹,

El-Zahar²,

Anwar³

2015

JPP

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Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1-100 nanometers range. Objects at this scale, such as "nanoparticles," take on novel properties and functions that differ markedly from those seen in the bulk scale. The small size, surface tailor ability, improved solubility, and multifunctional of nanoparticles open many new research avenues for biologists. Nanoparticles are classified into inorganic nanoparticles such as gold nanoparticles and organic nanoparticles such as carbon nanotubes and dendrimers. Different types of nanoparticals such as nanocrystals, liposomes, polymeric nanoparticles, dendrimers, quantum dots and superparamagnetic nanoparticles illustrated different examples of promising nanoparticles for cancer treatment and imaging.

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“…These nanoparticles are a useful carrier system. Delivery of the protein inhibitor into tumor cells was rapid and useful to inhibit intracellular proteolysis [124].…”

Section: Cystatinsmentioning

confidence: 99%

Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

Serpe

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Cancer as Drug Delivery Target Nanoparticles as Anticancer Drug Delivery System Conventional Nanoparticles Sterically Stabilized Nanoparticles Actively Targetable Nanoparticles Routes of Drug Nanoparticles Administration Anticancer Drug Nanoparticles Anthracyclines Reverse of P‐glycoprotein Mediated Multidrug Resistance of Cancer Cells to Doxorubicin Antiestrogens Anti‐metabolites Camptothecins Cisplatin Paclitaxel Miscellaneous Agents Arsenic Trioxide Butyric Acid Cystatins Diethylenetriaminepentaacetic Acid Mitoxantrone Gene Therapy

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Poly(lactide-co-glycolide) nanoparticles as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells

Cited by 60 publications

References 30 publications

Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Nanotechnology in Cancer Diagnosis and Treatment

Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

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