Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation

Behan, Niall

doi:10.1016/s0142-9612(00)00286-6

Cited by 154 publications

(109 citation statements)

References 11 publications

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“…Such phenomenon may be described by cryoprotectant effect of this compound. In the absence of dextran, formed nanoparticles coagulated rapidly and were colloidally unstable [2]. We also observed aggregates of nanoparticles at dextran concentration of 0.1 %.…”

Section: Discussionmentioning

confidence: 59%

“…The temperature effect may be useful to apply during nanoparticles stabilization process by the dextran. The efficient rotation radius of dextran would correspondingly increase with temperature which can improve steric stabilization [2]. Polymerization time as an effective factor led to longer chains and potentially larger particles formation.…”

Section: Discussionmentioning

confidence: 99%

“…He illustrated that submicron particle size can be prepared by scattering alkyl cyanoacrylate monomers in HCl solution at low pH containing an emulsifier. The mechanism of polymerization is anionic based on the plan demonstrated by Behan in which the initiator anion was hydroxyl [2]. Studying several reaction variables comprehensively, Douglas recognized pH and monomer concentration as the most effective factors on the ultimate properties of the nanoparticles [3].…”

Section: Introductionmentioning

confidence: 99%

“…Muller described the production of particles of diverse size by means of the same reaction circumstances and reagents where the only variable was the monomer supply [8]. Behan showed that most efficient medium for particle formation was one with pH 2.5 at a temperature of 65°C, with dextran 70 as a steric stabilizer [2]. Emulsion polymerization allows some intrinsic advantages like higher rate of polymerization.…”

Section: Introductionmentioning

confidence: 99%

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An Investigation into the Parameters Affecting Preparation of Polybutyl Cyanoacrylate Nanoparticles by Emulsion Polymerization

et al. 2013

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Emulsion polymerization was used to synthesize poly butyl cyanoacrylate nanoparticles in presence of steric stabilizer dextran 70. Nanoparticles were characterized by particle size analysis, scanning electron microscopy and light microscopy. Polymerization factors affecting particle size and distribution such as dextran 70, polysorbate 80 (PS 80) and H ? concentration, polymerization time and temperature, and sonication were studied. Distinct concentrations of stabilizer were needed to produce proper nanoparticles. In this case, the appropriate value was 2 % of total volume. At pH 4 significant decrease in production efficiency demonstrated the substantial effect of H ? concentration on nanoparticles. Furthermore significant increases in particle size and distribution was observed at 50°C compared to room temperature. 0.001 % (v/v) PS 80 represented notable influence on size and distribution. In addition, shaped nanoparticles were obtained by altering polymerization time from 5.5 h to 18 h. Finally, nanoparticle features were influenced by different factors. Appropriate manipulating of such factors can lead to obtaining desirable nanoparticles.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Investigation into the Parameters Affecting Preparation of Polybutyl Cyanoacrylate Nanoparticles by Emulsion Polymerization

et al. 2013

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“…This shift in the peak of QT-PBCA NPs has been stronger than that of free QT. The C≡N peak at 2,249.83 cm -1 on n-BCA is also present in the spectra of blank PBCA NPs and QT-PBCA, indicating that C≡N did not take part in the polymerization reaction 39 (arrows marked in Figure 4A-C). In short, the characteristic bands of QT (1,600-1,400 cm -1 ) were observed in loaded NPs and did not participate in the polymerization reaction.…”

Section: Figure 4 Ftir Spectrum Of N-bca Monomer (A) Blank Pbca Nps mentioning

confidence: 99%

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Bagad¹,

Khan²

2015

IJN

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Background Quercetin (QT) is a potential bioflavonol and antioxidant with poor bioavailability and very low distribution in the brain. A new oral delivery system comprising of poly(n-butylcyanoacrylate) nanoparticles (PBCA NPs) was introduced to improve the oral bioavailability of QT and to increase its distribution in the brain. Physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80) were investigated. Objective This study aimed to investigate the physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80). Results The results showed that QT-PBCA NPs and QT-PBCA NPs coated with P-80 (QT-PBCA+P-80) had mean particle sizes of 161.1±0.44 nm and 166.6±0.33 nm respectively, and appeared spherical in shape under transmission electron microscopy. The mean entrapment efficiency was 79.86%±0.45% for QT-PBCA NPs and 74.58%±1.44% for QT-PBCA+P-80. The in vitro release of QT-PBCA NPs and QT-PBCA+P-80 showed an initial burst release followed by a sustained release when compared to free QT. The relative bioavailability of QT-PBCA NPs and QT-PBCA+P-80 enhanced QT bioavailability by 2.38- and 4.93-fold respectively, when compared to free QT. The biodistribution study in rats showed that a higher concentration of QT was detected in the brain after the NPs were coated with P-80. Conclusion This study indicates that PBCA NPs coated with P-80 can be potential drug carriers for poorly water-soluble drugs. These NPs were observed to improve the drugs’ oral bioavailability and enhance their transport to the brain.

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Synthesis and In-vitro drug release of insulin-loaded poly(n-butyl cyanoacrylate) nanoparticles

2002

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Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation

Cited by 154 publications

References 11 publications

An Investigation into the Parameters Affecting Preparation of Polybutyl Cyanoacrylate Nanoparticles by Emulsion Polymerization

An Investigation into the Parameters Affecting Preparation of Polybutyl Cyanoacrylate Nanoparticles by Emulsion Polymerization

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Synthesis and In-vitro drug release of insulin-loaded poly(n-butyl cyanoacrylate) nanoparticles

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