Poly(N,N-dimethylaminoethyl methacrylate) as a bioactive polyelectrolyte—production and properties

Abstract

Poly(N,N-dimethylaminoethyl methacrylate) is a polyelectrolyte with many important chemical and physical properties and, above all, offers a wide range of interesting biological properties. Currently, research on this polymer is ongoing in several centres around the world. The process of polymerizing the monomer is not easy, as there are difficulties in obtaining a product with repeatable properties. This work collected and described most of the currently known and used polymerization methods of N,N-dimethylaminoethyl methacrylate, taking into account the type of method, the solvent used, the initiator, as well as the process temperature and the average molecular weight of the polymer obtained. The most important properties of the discussed polymer, such as solubility, bioactivity, hydrophilicity, cytotoxicity, conductivity, and thermal and hydrodynamic parameters, are discussed on the basis of the available scientific literature. This work aims, among other things, to increase the possibility of using poly(N,N-dimethylaminoethyl methacrylate) as a material in advanced practical applications. Therefore, various methods of applied use of the polymer in question have also been described so far. Copolymers of the N,N-dimethylaminoethyl methacrylate are now too large a collection to fit in a single publication. Therefore, only the most interesting examples were cited in this work.

Polymeric Nanoparticles Containing Ruthenium Complexes for Biomedical Applications: A Mini-Review on Recent Developments

“…83 PDMAEMA is also temperature-dependent. 84 For example, a ruthenium(II) polypyridyl complex used for PDT was encapsulated in micelles made of a thermoresponsive PDMAEMA-containing polymer (Scheme 1). 85 More specifically, PDMAEMA-based block copolymers with either poly(methyl methacrylate) (PMMA) or a statistical copolymer (PMMA-co-PDMAEMA) as a second block segment were synthesized by sequential anionic polymerization strategies.…”

“…It is therefore possible to shift the pH region of aggregation of polymers containing such a pH-responsive moiety by modifying the overall polymer composition . PDMAEMA is also temperature-dependent . For example, a ruthenium(II) polypyridyl complex used for PDT was encapsulated in micelles made of a thermoresponsive PDMAEMA-containing polymer (Scheme ).…”

Design of metal oxide nanoparticles‐embedded polymeric nanocomposites for hydrogen peroxide chronoamperometric sensor

“…27 Poly(DMAEMA) exhibits electrical conductivity in both hydrochloride and ordinary states, demonstrating conducting power at various temperatures and frequencies in these two states. 28 Superhydrophilic polyacrylic acid (PAA) is an excellent choice as a doping agent due to the existence of a carboxyl group on the side chain. 29 PAA, a water-soluble polymer has garnered significant attention due to its versatility in various industries.…”

“…It is worth mentioning that the polymerization of poly(DMAEMA) is challenging, and several methods have been developed in the literature to produce it 27 . Poly(DMAEMA) exhibits electrical conductivity in both hydrochloride and ordinary states, demonstrating conducting power at various temperatures and frequencies in these two states 28 …”