Poly(N-vinyl-2-pyrrolidone) hydrogels produced by Fenton reaction

Barros, J.A.G.; Fechine, Guilhermino J. M.; Alcântara, Maria Regina; Catalani, Luiz H.

doi:10.1016/j.polymer.2006.10.033

Cited by 55 publications

(46 citation statements)

References 21 publications

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“…The most commonly used lubricious coatings in medical devices consist of water-soluble polymers, such as polyvinylpyrrolidone (PVP) [15], which is approved by FDA, as a biocompatible and non-antigenic compound and widely used in pharmaceutical formulations [16]. Crosslinking of PVP can be performed via chemical reactions, e.g., Fentons reaction relying on the reduction of hydrogen peroxide at the expense of Fe 2+ -ions under formation of hydroxyl radicals initiating vinylic polymerization [17]. Due to the non-necessity of chemical reagents with the advantage of improved biocompatibility, electron beam, or gamma radiation, which similarly lead to hydroxyl radicals from water radiolysis, are more convenient for medical devices [18].…”

Section: Introductionmentioning

confidence: 99%

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

Petersen¹,

Minrath²,

Kaule³

et al. 2013

Coatings

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Polyvinylpyrrolidone (PVP) is a conventionally applied hydrophilic lubricious coating on catheter-based cardiovascular devices, used in order to ease movement through the vasculature. Its use as drug reservoir and transfer agent on drug-coated balloons (DCB) is therefore extremely promising with regard to the simplification of its approval as a medical device. Here, we developed a PVP-based coating for DCB, containing paclitaxel (PTX) as a model drug, and studied the impact of crosslinking via UV radiation on drug stability, wash off, and transfer during simulated use in an in vitro vessel model. We showed that crosslinking was essential for coating stability and needed to be performed prior to PTX incorporation due to decreased drug bioavailability as a result of photodecomposition and/or involvement in vinylic polymerization with PVP under UV radiation. Moreover, the crosslinking time needed to be carefully controlled. While short radiation times did not provide enough coating stability, associated with high wash off rates during DCB insertion, long radiation times lowered drug transfer efficiency upon balloon expansion. A ten minutes radiation of PVP, however, combined a minimized drug wash off rate of 34% with an OPEN ACCESSCoatings 2013, 3 254 efficient drug transfer of 49%, underlining the high potential of photochemically crosslinked PVP as a coating matrix for DCB.

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Section: Introductionmentioning

confidence: 99%

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

Petersen¹,

Minrath²,

Kaule³

et al. 2013

Coatings

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“…22 As Fe 2+ can be oxidized to Fe 3+ inside vesicles before H 2 O 2 addition, to promote crosslinking by photoFenton reaction 21 H 2 O 2 containing vesicles suspension was submitted to 12 h of UV radiation (360 nm). The hydrogel particles were purified by lysing vesicles washing 3× with ethanol 50%.…”

Section: Pvp Entrapped Polymerizationmentioning

confidence: 99%

“…The Fenton reaction, an efficient method to obtain PVP hydrogels with good mechanical properties, 22 has been used to obtain PVP nanogels with superabsorbent properties. 10 Photo-Fenton reaction, a photochemical analog of Fenton reaction, also produces PVP hydrogels 21 (Scheme 1).…”

Section: Crosslinking Reactionmentioning

confidence: 99%

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Preparation of PVP hydrogel nanoparticles using lecithin vesicles

Bueno¹,

Catalani²,

Perez³

et al. 2010

Quím. Nova

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Recebido em 21/6/10; aceito em 20/8/10; publicado na web em 15/10/10 Hydrogels micro, sub-micro and nanoparticles are of great interest for drug encapsulation and delivery or as embolotherapic agents. In this work it is described the preparation of nano and sub-microparticles of pre-formed, high molecular weight and monomer free poly(N-vinyl-2-pyrrolidone) encapsulated inside the core of lecithin vesicles. The hydrogel particles are formed with a very narrow diameter distribution, of about 800 nm, and a moderate swelling ratio, of approximately 10.

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“…Proceso de injerto llevado a cabo por el método de pre-irradiación. La generación de radicales libres puede darse a través de una reacción de óxido-reducción [31], por oxidación directa de la cadena polimérica en presencia de ciertos metales [32], usando metales quelatados [33]. Una de las limitaciones de esta técnica es que se debe seleccionar un apropiado proceso oxidativo, por ejemplo, un sistema con alto potencial redox podría reaccionar con los monómeros incrementando la homopolimerización.…”

Section: Irradiación Directa En Presencia De Vaporunclassified

Aplicaciones de radiación gamma y UV para el injerto molecular y el diseño de matrices para aplicaciones terapéuticas

Ortiz¹,

Burillo²,

Bucio³

Biomateriais Aplicados Ao Desenvolvimento De Sistemas Terapêuticos Avançados

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Poly(N-vinyl-2-pyrrolidone) hydrogels produced by Fenton reaction

Cited by 55 publications

References 21 publications

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

Preparation of PVP hydrogel nanoparticles using lecithin vesicles

Aplicaciones de radiación gamma y UV para el injerto molecular y el diseño de matrices para aplicaciones terapéuticas

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