Poly(N-vinylpyrrolidone)-block-poly(d,l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation

Garrec, Dorothée Le; Gori, Sandra; Luo, Lan; Lessard, D.; Smith, Daniel; Yessine, M.-A.; Ranger, Maxime; Leroux, Jean‐Christophe

doi:10.1016/j.jconrel.2004.06.018

Cited by 233 publications

(139 citation statements)

References 54 publications

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“…In this synthesis, PVP (polyvinylpyrrolidone) polymer was used to stabilise the Fe3O4 nanoparticles, and also to form a homogenous layer surrounding them that has a negative charge. PVP is amphiphilic, non-toxic and non-ionic and already has a broad spectrum of biomedical applications [25]. Gold seeds were prepared through the reduction of chloroauric acid using NaBH4 in the presence of CTAB, and these seeds assemble on the PVP-coated Fe3O4 through electrostatic interaction.…”

Section: Synthesis Of Core/polymer/shell Magnetic-plasmonic Nanopartimentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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Magnetic plasmonic nanomaterials are of great interest in the field of biomedicine due to their vast number of potential applications, for example, in molecular imaging, photothermal therapy, magnetic hyperthermia and as drug delivery vehicles. The multimodal nature of these nanoparticles means that they are potentially ideal theranostic agents-i.e., they can be used both as therapeutic and diagnostic tools. This review details progress in the field of magnetic-plasmonic nanomaterials over the past ten years, focusing on significant developments that have been made and outlining the future work that still needs to be done in this fast emerging area. The review describes the main synthetic approaches to each type of magnetic plasmonic nanomaterial and the potential biomedical applications of these hybrid nanomaterials.

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Section: Synthesis Of Core/polymer/shell Magnetic-plasmonic Nanopartimentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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“…15,16 This advantage may mainly derive from the efficient cellular uptake of drug-loaded nanoparticles and the controlled delivery of UA in tumor cells. 28 In vivo evaluation of UA-NPs in H22-transplanted mice Figure 6A indicates the tumor growth curves of mice treated with different agents. Both free UA and UA-NPs delayed tumor growth in a dose-dependent manner, while UA-NPs led to a more retarded growth from day 5.…”

Section: Enhanced Proliferation Inhibition and Apoptotic Induction Ofmentioning

confidence: 99%

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

Zhang¹,

Zheng²,

Jing³

et al. 2015

IJN

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Previous reports have shown that ursolic acid (UA), a pentacyclic triterpenoid derived from Catharanthus trichophyllus roots, could inhibit the growth of a series of cancer cells. However, the potential for clinical application of UA is greatly hampered by its poor solubility, whereas the hydrophobicity of UA renders it a promising model drug for nanosized delivery systems. In the current study, we loaded UA into amphiphilic poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles and performed physiochemical characterization as well as analysis of the releasing capacity. In vitro experiments indicated that UA-NPs inhibited the growth of liver cancer cells and induced cellular apoptosis more efficiently than did free UA. Moreover, UA-NPs significantly delayed tumor growth and localized to the tumor site when compared with the equivalent dose of UA. In addition, both Western blotting and immunohistochemistry suggested that the possible mechanism of the superior efficiency of UA-NPs is mediation by the regulation of apoptosis-related proteins. Therefore, UA-NPs show potential as a promising nanosized drug system for liver cancer therapy.

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“…Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23]. Of synthetic polymers, PVP is water-soluble, non-charged, non-toxic, and is used in various medical applications [24]. While there is a potential concern about covalent interaction between hydrophilic polymers and magnetic nanoparticles in order to increase their stability in physiological medium [25][26][27][28][29], PVP coating on Fe 3 O 4 nanoparticles in all previous works has been achieved through noncovalent interaction.…”

mentioning

confidence: 99%

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

Arsalani¹,

Fattahi²,

Nazarpoor³

2010

Express Polym. Lett.

236

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Abstract. The magnetite (Fe3O4) nanoparticles (MNPs) coated with poly(N-vinyl pyrrolidone) (PVP) via covalent bonds were prepared as T2 contrast agent for magnetic resonance imaging (MRI). The surface of MNPs was first coated with 3-(trimethoxysilyl) propyl methacrylate (silan A) by a silanization reaction to introduce reactive vinyl groups onto the surface, then poly(N-vinyl pyrrolidone) was grafted onto the surface of modified-MNPs via surface-initiated radical polymerization. The obtained nanoparticles were characterized by FT-IR (Fourier transform infrared spectroscopy), XRD (X-ray diffraction), TEM (transmission electron microscopy), VSM (vibrating sample magnetometer), and TGA (thermogravimetric analysis). The MNPs had an average size of 14 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. T2-weighted MRI images of PVP-grafted MNPs showed that the magnetic resonance signal is enhanced significantly with increasing nanoparticle concentration in water. The r1 and r2 values per millimole Fe, and r2/r1 value of the PVP-grafted MNPs were calculated to be 2.6 , 72.1, and 28.1(mmol/l) -1 ·s -1 , respectively. These results indicate that the PVP-grafted MNPs have great potential for application in MRI as a T2 contrast agent. Vol.4, No.6 (2010) 329-338 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2010.42 region that they are accumulated, and hence cause negative contrast and provide a dark state in the image where the compounds are accumulated [15]. However, the direct use of magnetic nanoparticles as in vivo MRI contrast agent results in biofouling of the particles in blood plasma and formation of aggregates that are quickly sequestered by cells of the reticular endothelial system (RES) such as macrophages [16,17]. Furthermore, aggregated nanoparticles change their superparamagnetic response [7]. Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23]. Of synthetic polymers, PVP is water-soluble, non-charged, non-toxic, and is used in various medical applications [24]. While there is a potential concern about covalent interaction between hydrophilic polymers and magnetic nanoparticles in order to increase their stability in physiological medium [25][26][27][28][29], PVP coating on Fe 3 O 4 nanoparticles in all previous works has been achieved through noncovalent interaction. Now, polymers grafting of magnetic nanoparticles is one of the most attractive methods of surface modification [30,31]. In the present study, we carried out chemical synthesis and characterization of PVP-functionalized magnetite (Fe 3 O 4 ) nanoparticles. Since the PVP was bonded to the surface of magnetite nanoparticles through covalent bonds, the prepared magnetic fluid (ferrofluid) was ve...

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Poly(N-vinylpyrrolidone)-block-poly(d,l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation

Cited by 233 publications

References 54 publications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

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Poly(N-vinylpyrrolidone)-block-poly(d,l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation

Cited by 233 publications

References 54 publications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (&epsilon;-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

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Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo