Poly(n-vinylpyrrolidone) hydrogels: 2.Hydrogel composites as wound dressing for tropical environment

a b s t r a c tDiabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.

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“…This is mostly due to its water absorption and oxygen permeability properties [231,232]. PVP hydrogels can be produced at relatively low cost.…”

Section: Poly(vinyl Pyrrolidone) (Pvp)mentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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“…The PEG chains settle among the PVP chains, avoiding crosslinking, and decrease the physical interactions between PVP chains. Moreover, Hilmy et al 19 used PEG in PVP hydrogels and they observed that the presence of PEG could improve the hydrogel barrier against bacteria.…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

Radiation synthesis of poly(N‐vinyl‐2‐pyrrolidone)–κ‐carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests

Şen

Avcı

2005

J Biomedical Materials Res

101

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Poly(N-vinyl-2-pyrrolidone)--carrageenan hydrogels (PVP-KC) were prepared by irradiating the mixtures of aqueous solutions of PVP, KC, potassium chloride, and poly(ethylene glycol) by ␥-rays at different doses. Their preliminary laboratory tests were evaluated to identify their usability in wound dressing applications. For investigation of the effect of components on the gelation of PVP, sol-gel analyses were made and gel fractions of the hydrogels were determined. Mechanical experiments were conducted for both unirradiated and irradiated samples. For investigation of the fluid uptake capacity of the hydrogels, swelling experiments were performed in pseudo-extracellular fluid solution at various temperatures. Acidity/alkalinity (pH) and electrical conductivity tests were achieved from aqueous extracts of hydrogels, and bioadhesion strength of the hydrogels was investigated on human skin.

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“…Pieces of amniotic membranes were placed on Soyabean Casein Digest Agar plates. Suspensions of bacteria were prepared in sterile water and placed on the opposite surface of membranes and incubated [18]. Plates were checked after 24 h of incubation for growth and ability of the test organisms to migrate across the dressing surface.…”

Section: Storage Studiesmentioning

confidence: 99%

Dried gamma-irradiated amniotic membrane as dressing in burn wound care

Singh

Chacharkar

2011

Journal of Tissue Viability

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Poly(n-vinylpyrrolidone) hydrogels: 2.Hydrogel composites as wound dressing for tropical environment

Cited by 44 publications

References 4 publications

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Radiation synthesis of poly(N‐vinyl‐2‐pyrrolidone)–κ‐carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests

Dried gamma-irradiated amniotic membrane as dressing in burn wound care

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