2023
DOI: 10.1002/adfm.202303147
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Poly(pentahydropyrimidine)‐Based Hybrid Hydrogel with Synergistic Antibacterial and Pro‐Angiogenic Ability for the Therapy of Diabetic Foot Ulcers

Abstract: Bacterial infection and impaired angiogenesis make the treatment of diabetic foot ulcers (DFU) extremely challenging. Cationic polymers are expected to treat infected wounds due to their excellent antibacterial properties, but still, it is difficult to meet the therapeutic needs of pro‐angiogenesis and anti‐infections due to their simple construction units and outmoded synthesis methods. Herein, a cationic poly(pentahydropyrimidine) (PPHP) library with strong modifiability is synthesized to construct a hybrid … Show more

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Cited by 20 publications
(6 citation statements)
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“…Taking advantages of the fast assembly property and excellent photothermal effect, the TA/Fe nanoparticles or coatings have been used intensively to combat bacterial infections. 38 Generally, a satisfactory photothermal therapy (PTT) would require prolonged and hyperthermic (above 70 °C) treatments, however, the hyperthermia effect would inevitably lead to severe side effects for patients. 39 As an alternative, the synergism of photodynamic therapy (PDT) and PTT could achieve superior antibacterial performances under moderate temperatures and biocompatible conditions.…”
Section: Resultsmentioning
confidence: 99%
“…Taking advantages of the fast assembly property and excellent photothermal effect, the TA/Fe nanoparticles or coatings have been used intensively to combat bacterial infections. 38 Generally, a satisfactory photothermal therapy (PTT) would require prolonged and hyperthermic (above 70 °C) treatments, however, the hyperthermia effect would inevitably lead to severe side effects for patients. 39 As an alternative, the synergism of photodynamic therapy (PDT) and PTT could achieve superior antibacterial performances under moderate temperatures and biocompatible conditions.…”
Section: Resultsmentioning
confidence: 99%
“…Additionally, vasotropic drugs have been incorporated into hydrogels in diverse forms to create angiogenic hydrogels. Li et al 145 developed a cationic hybrid hydrogel inspired by the natural properties of hot springs. This hydrogel exhibits mild thermal effect specifically at the site of diabetic wounds with bacterial infections.…”
Section: The Complex Microenvironment Of Diabetic Wounds and The Cust...mentioning
confidence: 99%
“… ( A ) Chemical bonding during hydrogel preparation [ 77 ]. ( B ) TA–metal ion coordination complex crosslinked citrate-based mussel-inspired bio-adhesives [ 29 ].…”
Section: Smart Responsive Hydrogel Designmentioning
confidence: 99%