Poly(( R , S )-3,3-dimethylmalic acid) derivatives as a promising cardiovascular metallic stent coating: Biodegradation and biocompatibility of the hydrolysis products in human endothelial cells

New promising biodegradable polyesters derived from poly((R,S)-3,3-dimethylmalic acid) for cardiovascular applications

“…This deference can be observed by the slow degradation of the polymer chains indicated by an increase of the retention time with the presence of a single peak or with the presence of others picks with a smaller molecular weight. It was showed that all PDMMLA homopolymers were hydrolyzed with the formation of a second peak corresponding to small molecular weight and indicating a mixed degradation type in bulk and surface corrosion compared with PLA degradation which was rather in bulk [93]. The ratio of this second peak increased with the decrease of the ratio of the first peak over time.…”

“…This metabolite is present in the synthesis of Coenzyme A and gives ketovaline by enzymatic oxidative reaction catalyzed by β,β--dimethyldehydrogenase (EC.1.1.1.84) [78,80,81,91,92] (Figure 3). [93].…”

“…with the requirements of this application and it is achieved with well controlled molecular weight without transfer reactions that occur during the synthesis of PMLA [93,106,107].…”

“…Three homopolymers and three copolymers were analyzed for this study. The homopolymers have been investigated to understand the PDMMLAs degradation behavior under physiological conditions and the copolymers for their eventual use as a coating cardiovascular stent for the treatment of restenosis [93].…”

“…Homopolymer P2' (0/100) has a slower degradation rate while PDMMLA-COOH (100/0) has the most rapid rate of degradation. PDMMLA-OH has a slower molecular weight loss rate in comparison to PDMMLA-COOH ( Figure 17) [93]. Because of the presence of the functional group in the side chains of PDMMLA polymers comparing with other aliphatic polyesters such as PLA, their degradation behavior may be different.…”