Poly(sulfobetaine)s and corresponding cationic polymers. IX. Synthesis and aqueous solution properties of zwitterionic poly(sulfobetaine) derived from a styrene–N,N‐dimethylaminopropyl maleamidic acid copolymer

Abstract

A styrene-N,N-dimethyl(maleamidic acid)-propyl ammonium propane sulfonate (SDMMAAPS) copolymer was synthesized through an amidoacidation reaction of a styrene-maleic anhydride alternating copolymer with N,N-dimethylaminopropylamine (ring-opening reaction) and then reacted with propane sultone. The cloud point and minimum salt concentration (msc) of this ampholytic SDMMAAPS copolymer were determined in aqueous salt solutions. The effects of counterions on the cloud point and msc of SDMMAAPS were not entirely the same as those of other zwitterionic poly(sulfobetaine)s. The greatest difference from other poly(sulfobetaine)s, such as styrene-N,Ndimethyl(maleimido propyl)ammonium propane sulfonate copolymers, was the carboxylic group on the polymer chain unit of SDMMAAPS.

Recent advances of zwitterionic-based topological polymers for biomedical applications

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Zwitterionic Moieties from the Huisgen Reaction: A Case Study with Amphiphilic Dendritic Assemblies

“…Zwitterionics, such as sulfobetaines,28, 29 carboxybetaines,30, 31 and phosphobetaines,32, 33 possess both positive and negative charges on the same monomer unit. These polybetaines are gaining attention as potential alternatives to PEG, due to their overall charge neutrality, high water solubility, and their ability to bind water via electrostatic interactions.…”