Poly(thionine)-carbon nanotube modified carbon film electrodes and application to the simultaneous determination of acetaminophen and dipyrone

Abstract

Multi-walled carbon nanotube (MWCNT)-poly(thionine) (PTH) nanostructures were formed on carbon film electrodes (CFE), the polymer film being formed beneath or on top of MWCNT, to give two different sensor architectures, PTH/MWCNT/CFE or MWCNT/PTH/CFE. Characterization of the novel nanostructures was carried out by cyclic voltammetry, electrochemical impedance spectroscopy and scanning electron microscopy. The modified electrodes were then used for sensing acetaminophen (ACOP) and dipyrone by differential pulse voltammetry and fixedpotential amperometry independently and simultaneously. Analytical parameters were determined and the results compared with similarly modified electrodes reported in the literature. An interference study as well as recovery measurements in pharmaceutical samples was successfully performed.

PMo11V@N-CNT electrochemical properties and its application as electrochemical sensor for determination of acetaminophen

“…As far as we know, these have never been used for acetaminophen determination. Nevertheless, the obtained DL in this work is very close to that reported (0.83 × 10 −6 mol dm −3 ) for a similar study with a MnFe 2 O 4 @N-CNT [36] nanocomposite or with other carbon-based modified electrodes (Table 3)[ 32, 49, 50]a n d better than those obtained for poly(thionine) and poly(methylene green)/multi-walled carbon nanotube (MWCNT) modified electrodes [51,52]. The only sensor with better results was the N-MWCNTs/AuNPs [53] with a DF = 0.35 × 10 −6 mol dm −3 ; however, this involved the use of gold nanoparticles which is less cost-effective and requires more complex sensor architecture.…”

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

“…In general, the LOD values achieved in our study are higher than most of the data found in the literature. As can be seen in Table S3, the LODs reported in the literature for paracetamol, metamizole and midazolam ranged between 10 −5 −10 −10 mol L −1 , 10 −5 −10 −8 mol L −1 , and 10 −5 −10 −7 mol L −1 , respectively. On the other hand, the detectability levels obtained for metamizole and midazolam using ePADs were slightly better than those found in two reports.…”

“…While the performance of the ePADs is below other references , two advantages need to be highlighted. First, ePADs were prepared and used without any modification with nanomaterials or charge transfer mediators.…”

Iron Oxide Nanoparticle and Multiwalled Carbon Nanotube Modified Glassy Carbon Electrodes. Application to Levodopa Detection

“…Multiwalled carbon nanotubes (MWCNT) also possess outstanding characteristics, including good electrical conductivity, high mechanical strength and modulus, high chemical stability, large adsorption ability and catalytic properties . Furthermore, they can be an ideal matrix to interact with various inorganic and organic molecules, an advantageous property in the design and development of modified electrode electrochemical sensors .…”