Poly-ubiquitin catalyzes endocytosis by promoting liquid-like assembly of early endocytic proteins

Feng, Yuan; Gollapudi, Sadhana; Malady, Brandon T.; Sangani, Arjun; Wang, Liping; Lafer, Eileen M.; Stachowiak, Jeanne C.

doi:10.1016/j.bpj.2022.11.2471

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“…Similar results were obtained in mammalian cells, pointing to the central role of Eps15 in the formation of protein condensates both in vitro and in cellulo [25]. It was further shown that the addition of polyubiquitin stabilized Eps15 condensates.…”

Section: Ubiquitylation Is Essential For Receptor Internalization And...supporting

confidence: 77%

“…Moreover, the knockout of Eps15 blocked the initiation of endocytosis, and neither the expression of Eps15 lacking the ubiquitin-interacting motif nor of Eps15 fused to a deubiquitinating enzyme could rescue it. These data lead to the conclusion that ubiquitin is essential for a stable initiation of CME by participating in the assembly of a flexible protein network (Figure 1) [25].…”

Section: Ubiquitylation Is Essential For Receptor Internalization And...mentioning

confidence: 93%

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Recent Advances in the Importance of Ubiquitylation for Receptor Internalization and Signaling

Chastel,

Angers

2024

Physiology

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Receptor tyrosine kinases are activated by binding to their ligands, which trigger modifications in their cytoplasmic domains to initiate signal transduction. Control mechanisms to modulate the signaling of growth factor receptors are essential for proper signaling and require several levels of regulation. Post-translational modifications play crucial roles in intracellular trafficking through mechanisms that are not fully understood. Ubiquitylation is recognized as an essential signal in establishing molecular networks controlling receptor internalization and trafficking at the membrane and in sorting endosomes. In turn, receptor trafficking influences how the signaling networks are activated. Recent advances show how receptor targeting to clathrin-coated pits and internalization influences signaling by allowing specific target activation. At the same time, progress has been made in showing how membrane proteins are organized to facilitate the recruitment of activated receptors to clathrin-coated pits and how this whole process depends on the ubiquitylation of the receptors and endocytosis accessory proteins. Here, we review recent advances in the role of ubiquitylation in receptor internalization and trafficking.

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Section: Ubiquitylation Is Essential For Receptor Internalization And...supporting

confidence: 77%

Section: Ubiquitylation Is Essential For Receptor Internalization And...mentioning

confidence: 93%

Recent Advances in the Importance of Ubiquitylation for Receptor Internalization and Signaling

Chastel,

Angers

2024

Physiology

View full text Add to dashboard Cite

show abstract

Poly-ubiquitin catalyzes endocytosis by promoting liquid-like assembly of early endocytic proteins

Cited by 1 publication

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Recent Advances in the Importance of Ubiquitylation for Receptor Internalization and Signaling

Recent Advances in the Importance of Ubiquitylation for Receptor Internalization and Signaling

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