Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release

Seabra, Amedea B.; Oliveira, Marcelo Ganzarolli de

doi:10.1016/j.biomaterials.2003.10.035

Cited by 146 publications

(141 citation statements)

References 48 publications

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“…For this reason, PVA has been used in numerous devices in contact with blood and tissues such as drug-delivery systems, wound dressings, dialysis membranes, cardiovascular devices, artificial cartilage, tendon, ligament, cornea, lens, skin, and intervertebral disc. 4,23,28 A good blood-contact property was observed for pure PVA. 29 Moreover, bovine serum albumin (BSA) tends to adsorb to hydrophobic surfaces more than hydrophilic ones.…”

Section: Introductionmentioning

confidence: 90%

“…[1][2][3][23][24][25] The degree of swelling is 203%, 231% and 416% after 1 h, 4 h, and 24 h submersion of the blend nanofibrous mats, respectively.…”

Section: Dovepressmentioning

confidence: 98%

“…2,18 Because of its flexibility and swelling capability in an aqueous medium, PVA has been much studied as a wound dressing; 2 however, its poor stability in water has limited its use in aqueous systems, particularly for drug-delivery applications. 18,22 To overcome this problem, PVA has been made insoluble by grafting, 18 copolymerizing, 22 and cross-linking, 23 which require some additional and sometimes complicated and time-consuming processes. In wound dressing applications, PVA has been crosslinked with polyvinyl pyrrolidone, 2 sodium alginate, 24 and sterculia 25 to provide better characteristics, although a vey quick release burst was reported and a sustained release continued up to 90 hours, 5 hours, and 24 hours, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

141

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The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

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Section: Introductionmentioning

confidence: 90%

“…[1][2][3][23][24][25] The degree of swelling is 203%, 231% and 416% after 1 h, 4 h, and 24 h submersion of the blend nanofibrous mats, respectively.…”

Section: Dovepressmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

141

View full text Add to dashboard Cite

show abstract

“…There was also a concern on the technique for NO donor incorporation as the polymer melt may induce thermal decomposition of the NO donor, and result in decreased total NO release. Seabra et al [66] prepared solid polymeric membranes from the blend of poly (vinyl alcohol)/poly(vinyl pyrrolidone) (PVA/PVP) with GSNO addition. During the thermal decomposition of GSNO, the PVA/PVP-GSNO membranes exhibited an improved stabilization.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

et al. 2017

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Nitric oxide (NO) acts a pivotal role in regulating various physiological processes of vasodilation, platelet aggregation, and vascular smooth muscle cell mitogenesis and proliferation. This makes NO a promising candidate for the treatment of cardiovascular problems like hypertension and vascular stenosis. However, the high reactivity of NO poses an issue for effective NO delivery. To overcome this limitation, recent developments on three-dimensional (3D) materials have been explored with either physical or chemical incorporation of NO releasing donors, to provide spatiotemporal control over NO-signaling pathways in blood vessels. Here, we offer an overview on the current efforts, and propose future perspectives for precise regulation on NO delivery in advanced 3D materials toward proper vascular functionality.

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“…The physical, mechanical and thermal properties of PVA and PVP matrixes can be modulated by varying the PVA/PVP ratio. These two polymers and their blends have been used in numerous applications, including biomedical films [20], transdermal [21,22] and buccal patches [13,14]. Nevertheless, to the best of our knowledge, the relationships between PVA/PVP ratios and the mucoadhesion property of buccal patches, as well as the permeation behaviour of the hydrophilic drug through the mucosa are not well established.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

Jaipakdee

Limpongsa

2018

Int J App Pharm

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Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix. Conclusion:Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release

Cited by 146 publications

References 48 publications

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

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