Poly(vinyl alcohol) Hydrogels: The Old and New Functional Materials

Wang, Menghan; Bai, Jianzhong; Shao, Kan; Tang, Wenwei; Zhao, Xueling; Lin, Donghai; Huang, Shan; Chen, Cheng; Ding, Zheng; Ye, Jiayi

doi:10.1155/2021/2225426

Cited by 95 publications

(72 citation statements)

References 146 publications

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“…In addition to mechanical strength, the crosslinking degree affects hydrogel adhesion simultaneously. For PVA hydrogels prepared by the F-T cycle, on the one hand, most of the hydroxyl groups on PVA formed hydrogen bonds used for crosslinking during the F-T process, which resulted in the lack of free hydroxyl groups used for adhesion [ 7 , 27 ]. On the other hand, the increase in the crosslinking degree of the PVA hydrogels limited the accessibility of hydroxyl groups due to the decrease in segment mobility.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

Kumar

et al. 2022

Gels

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The development of adhesive hydrogel materials has brought numerous advances to biomedical engineering. Hydrogel adhesion has drawn much attention in research and applications. In this paper, the study of hydrogel adhesion is no longer limited to the surface of hydrogels. Here, the effect of the internal crosslinking degree of hydrogels prepared by different methods on hydrogel adhesion was explored to find the generality. The results show that with the increase in crosslinking degree, the hydrogel adhesion decreased significantly due to the limitation of segment mobility. Moreover, two simple strategies to improve hydrogel adhesion generated by hydrogen bonding were proposed. One was to keep the functional groups used for hydrogel adhesion and the other was to enhance the flexibility of polymer chains that make up hydrogels. We hope this study can provide another approach for improving the hydrogel adhesion generated by hydrogen bonding.

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Section: Resultsmentioning

confidence: 99%

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

Kumar

et al. 2022

Gels

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“…Additionally, it is also desired for tissue engineering that such materials intrinsically show improved mechanical properties (such as hardness and elasticity) and structure (such as porosity and density) in order to be compatible with embedded tissues. So far, the development of multifunctional hydrogels to meet complex biological conditions in vivo and achieve the adequate synergy with live organisms remains a current challenge [ 34 ]. Based on the concept, among the different polymers used to date, PVA deserves especial attention because it could be an excellent polymer that has several beneficial effects and is easy to form complex microstructures.…”

Section: Introductionmentioning

confidence: 99%

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Elango

Zamora‐Ledezma

Negrete-Bolagay

et al. 2022

IJMS

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Polyvinyl alcohol (PVA) hydrogels are well-known biomimetic 3D systems for mammalian cell cultures to mimic native tissues. Recently, several biomolecules were intended for use in PVA hydrogels to improve their biological properties. However, retinol, an important biomolecule, has not been combined with a PVA hydrogel for culturing bone marrow mesenchymal stem (BMMS) cells. Thus, for the first time, the effect of retinol on the physicochemical, antimicrobial, and cell proliferative properties of a PVA hydrogel was investigated. The ability of protein (3.15 nm) and mineral adsorption (4.8 mg/mL) of a PVA hydrogel was improved by 0.5 wt.% retinol. The antimicrobial effect of hydrogel was more significant in S. aureus (39.3 mm) than in E. coli (14.6 mm), and the effect was improved by increasing the retinol concentration. The BMMS cell proliferation was more upregulated in retinol-loaded PVA hydrogel than in the control at 7 days. We demonstrate that the respective in vitro degradation rate of retinol-loaded PVA hydrogels (RPH) (75–78% degradation) may promote both antibacterial and cellular proliferation. Interestingly, the incorporation of retinol did not affect the cell-loading capacity of PVA hydrogel. Accordingly, the fabricated PVA retinol hydrogel proved its compatibility in a stem cell culture and could be a potential biomaterial for tissue regeneration.

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“…Hydrogels prepared from a single material are widely used in biological tissue engineering [ 2 ]. However, in other application fields, such as contact lenses [ 3 ], wound dressings [ 4 ], slow drug release [ 5 ], tissue scaffolds [ 6 ], and drug delivery carriers [ 7 ], low strength and toughness limit the development of hydrogels. Studies have shown that the common mechanical properties of hydrogels are as follows.…”

Section: Introductionmentioning

confidence: 99%

Research Advances in Mechanical Properties and Applications of Dual Network Hydrogels

Ning

Huang

Yimuhan

et al. 2022

IJMS

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Hydrogels with a three-dimensional network structure are particularly outstanding in water absorption and water retention because water exists stably in the interior, making the gel appear elastic and solid. Although traditional hydrogels have good water absorption and high water content, they have poor mechanical properties and are not strong enough to be applied in some scenarios today. The proposal of double-network hydrogels has dramatically improved the toughness and mechanical strength of hydrogels that can adapt to different environments. Based on ensuring the properties of hydrogels, they themselves will not be damaged by excessive pressure and tension. This review introduces preparation methods for double-network hydrogels and ways to improve the mechanical properties of three typical gels. In addition to improving the mechanical properties, the biocompatibility and swelling properties of hydrogels enable them to be applied in the fields of biomedicine, intelligent sensors, and ion adsorption.

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Poly(vinyl alcohol) Hydrogels: The Old and New Functional Materials

Cited by 95 publications

References 146 publications

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Research Advances in Mechanical Properties and Applications of Dual Network Hydrogels

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