Poly(γ-glutamic acid)–silica hybrids with fibrous structure: effect of cation and silica concentration on molecular structure, degradation rate and tensile properties

Obata, Akiko; Ito, Shingo; Iwanaga, Norihiko; Mizuno, Toshihisa; Jones, Julian R.; Kasuga, Toshihiro

doi:10.1039/c4ra08777a

Cited by 15 publications

(24 citation statements)

References 43 publications

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“…The characteristic peak was observed at 3281 cm −1 with the chelate formation, which due to the existence of calcium ions. At the same time, characteristic peak of carbonyl disappeared since amino group and carboxyl group of γ‐PGA participation in the chelation reaction directly …”

Section: Resultsmentioning

confidence: 97%

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Degradation performance of polyglutamic acid and its application of calcium supplement

Zhan

Chi

et al. 2018

Polymers for Advanced Techs

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Degradable biopolymers with functional groups play a crucial role in the biomedical field. In this case, the influences of temperature and pH values on the degradation performance of poly (γ‐glutamic acid) (γ‐PGA) were fully explored by gel permeation chromatography. Further, γ‐PGA‐Ca was prepared by using calcium chloride to react with the low molecular weight γ‐PGA and characterized by Fourier transform infrared, differential scanning calorimetry test, gel permeation chromatography, atomic absorption spectrophotometric, Ca2+ release in vivo, and cytotoxicity experiments. Furthermore, Caco‐2 cell model was constructed to study the mechanism of γ‐PGA‐Ca intestinal absorption. Results indicated that low pH value and high temperature are the suitable conditions for the degradation of γ‐PGA. It also suggested that γ‐PGA‐Ca can be used as calcium supplements due to its high rate of absorption.

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Section: Resultsmentioning

confidence: 97%

“…At the same time, characteristic peak of carbonyl disappeared since amino group and carboxyl group of γ-PGA participation in the chelation reaction directly. 37,38 3.4 | GPC analysis of γ-PGA and γ-PGA-Ca…”

Section: Infrared Spectroscopic Of γ-Pga and γ-Pga-camentioning

confidence: 99%

Degradation performance of polyglutamic acid and its application of calcium supplement

Zhan

Chi

et al. 2018

Polymers for Advanced Techs

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“…γ-PGA is an enzymatically degradable polymer based on amino acid glutamic acid and in the salt form is water soluble and, therefore, can be easily used in the sol-gel process. Electrospun scaffolds have also been fabricated from this hybrid [174,175]. Calcium salt of γ-PGA has also been used to incorporate calcium in the hybrid (Figure 3C) [164].…”

Section: Bone Tissue Engineering Scaffolds Encompass the Chemistrymentioning

confidence: 99%

Bone Repair and Regenerative Biomaterials: Towards Recapitulating the Microenvironment

et al. 2019

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Biomaterials and tissue engineering scaffolds play a central role to repair bone defects. Although ceramic derivatives have been historically used to repair bone, hybrid materials have emerged as viable alternatives. The rationale for hybrid bone biomaterials is to recapitulate the native bone composition to which these materials are intended to replace. In addition to the mechanical and dimensional stability, bone repair scaffolds are needed to provide suitable microenvironments for cells. Therefore, scaffolds serve more than a mere structural template suggesting a need for better and interactive biomaterials. In this review article, we aim to provide a summary of the current materials used in bone tissue engineering. Due to the ever-increasing scientific publications on this topic, this review cannot be exhaustive; however, we attempted to provide readers with the latest advance without being redundant. Furthermore, every attempt is made to ensure that seminal works and significant research findings are included, with minimal bias. After a concise review of crystalline calcium phosphates and non-crystalline bioactive glasses, the remaining sections of the manuscript are focused on organic-inorganic hybrid materials.

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“…GBR membranes composed of ultrafine nanofibers are more suitable for cell attachment and proliferation than conventional membranes with large scale structures. Various strategies—such as self-assembly, wet-spinning, and electrospinning—have been used to fabricate GBR membranes [ 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Of these strategies, electrospinning has attracted a great deal of attention because this method is very simple and versatile, and can produce various polymer nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane–Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration

et al. 2019

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To provide adequate conditions for the regeneration of damaged bone, it is necessary to develop piezoelectric porous membranes with antioxidant and anti-inflammatory activities. In this study, composite nanofibers comprising poly(vinylidene fluoride) (PVDF) and a polyhedral oligomeric silsesquioxane–epigallocatechin gallate (POSS–EGCG) conjugate were fabricated by electrospinning methods. The resulting composite nanofibers showed three-dimensionally interconnected porous structures. Their average diameters, ranging from 936 ± 223 nm to 1094 ± 394 nm, were hardly affected by the addition of the POSS–EGCG conjugate. On the other hand, the piezoelectric β-phase increased significantly from 77.4% to 88.1% after adding the POSS–EGCG conjugate. The mechanical strength of the composite nanofibers was ameliorated by the addition of the POSS–EGCG conjugate. The results of in vitro bioactivity tests exhibited that the proliferation and differentiation of osteoblasts (MC3T3-E1) on the nanofibers increased with the content of POSS–EGCG conjugate because of the improved piezoelectricity and antioxidant and anti-inflammatory properties of the nanofibers. All results could suggest that the PVDF composite nanofibers were effective for guided bone regeneration.

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Poly(γ-glutamic acid)–silica hybrids with fibrous structure: effect of cation and silica concentration on molecular structure, degradation rate and tensile properties

Cited by 15 publications

References 43 publications

Degradation performance of polyglutamic acid and its application of calcium supplement

Degradation performance of polyglutamic acid and its application of calcium supplement

Bone Repair and Regenerative Biomaterials: Towards Recapitulating the Microenvironment

Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane–Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration

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