Polyacrylamid/Silver Composite Particles Produced via Microfluidic Photopolymerization for Single Particle-Based SERS Microsensorics

Köhler, J. Michael; März, Anne; Popp, Jürgen; Knauer, Andrea; Kraus, Isabelle; Faerber, J.; Serra, Christophe A.

doi:10.1021/ac302751t

Cited by 58 publications

(67 citation statements)

References 26 publications

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“…Here, as the sensing application of these metal/polymer nanoassembly particles, a test SERS measurement of adenine analytes is performed. Intense local electric field within a few nanometers at the surface of Ag nanoparticles can be generated by LSPR which can enhance the Raman scattering cross‐section of molecules . When different concentrations of adenine solution were applied to the polymer/Au/Ag assembly particles, an intense and sharp SERS signal was observed at ≈738 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

Microfluidic Assisted Synthesis of Multipurpose Polymer Nanoassembly Particles for Fluorescence, LSPR, and SERS Activities

Visaveliya

Köhler

2015

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102

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Potential biomedical applications such as controlled delivery with sustained drug release profile demand for multifunctional polymeric particles of precise chemical composition and with welldefined physicochemical properties. The real challenge is to obtain the reproducible and homogeneous nanoparticles in a minimum number of preparation steps. Here, single-step nanoarchitectures of soft surface layered copolymer nanoparticles with a regular tuning in the size via micro flow-through assisted synthesis are reported. Interfacial copolymerization induces the controlled compartmentalization where a hydrophobic core adopts spherical shape in order to minimize the surface energy and simultaneously shelter in the hydrophilic shelllike surface layer. Surface layer can swell in the aqueous medium and allow controlled entrapping of functional hydrophobic nanoparticles in the hydrophilic interior via electrostatic interaction which can be particularly interesting for combined fluorescence activity. Furthermore, the nanoarchitecture of size and concentration controlled polymer-metal nanoassembly particles can be implemented as an ideal surface-enhanced Raman scattering substrate for detection of the trace amounts of various analytes.

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Section: Resultsmentioning

confidence: 99%

Microfluidic Assisted Synthesis of Multipurpose Polymer Nanoassembly Particles for Fluorescence, LSPR, and SERS Activities

Visaveliya

Köhler

2015

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102

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“…Particles loaded with different semiconductor or magnetic nanoparticles were produced in this way [21,25,26] . In a recent work [27] , polyacrylamide particles incorporating silver nanoparticles were produced as on-chip probes for microfluidic surface-enhanced Raman spectroscopy (SERS). Finally, the functionalization of polymer particles can also be realized in microfluidic processes, for example, by synthesizing porous particles like molecularly imprinted polymer (MIP) beads, which are used for the trace detection of analytes and for chromatographic purposes [19,28,29] .…”

Section: Polymer Particle Synthesismentioning

confidence: 99%

Synthesis of polymer particles and capsules employing microfluidic techniques

Bošković

Loebbecke

2014

Nanotechnology Reviews

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In the field of microfluidic particle synthesis, significant progress has been made during the past decade. Excellent control of the process and flow conditions allows the synthesis of particulate materials with unique properties, which are not achievable with conventional techniques. In this paper, we give a brief overview of the main strategies for microfluidic syntheses of polymer particles and microcapsules on the basis of continuous droplet formation as the initial process step. Additionally, we outline the major challenges, which have to be overcome to allow the fabrication of large quantities of novel microparticular products

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“…These composite microparticles allow an easy handling of nanoparticles and may find applications in sensorics as the plasmonic properties of encapsulated nanoparticles may be affected by pH, oxygen content, or analyte concentration. Preliminary experiments showed that Ag-nanoparticlesdoped poly(AA) microparticles exhibit a strong surface-enhanced Raman spectroscopy (SERS) signal upon contact with ademine concentration as low as 0.1 μM [26].…”

Section: Controlling Droplets and Microparticlesmentioning

confidence: 99%

Engineering Polymer Microparticles by Droplet Microfluidics

Serra¹,

Khan²,

Chang³

et al. 2013

J Flow Chem

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Capillary-based flow-focusing and co-flow microsystems were developed to produce sphere-like polymer microparticles of adjustable sizes in the range of 50 to 600 μm with a narrow size distribution (CV < 5%) and different morphologies (core-shell, janus, and capsules). Rod-like particles whose length was conveniently adjusted between 400 μm and few millimeters were also produced using the same microsystems. Influence of operating conditions (flow rate of the different fluid, microsystem characteristic dimensions, and design) as well as material parameters (viscosity of the different fluids and surface tension) was investigated. Empirical relationships were thus derived from experimental data to predict the microparticle's overall size, shell thickness, or rods length. Besides morphology, microparticles with various compositions were synthesized and their potential applications highlighted: drug-loaded microparticles for new drug delivery strategies, composed inorganic-organic multiscale microparticles for sensorics, and liquid crystalline elastomer microparticles showing an anisotropic reversible shape change upon temperature for thermal actuators or artificial muscles.

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Polyacrylamid/Silver Composite Particles Produced via Microfluidic Photopolymerization for Single Particle-Based SERS Microsensorics

Cited by 58 publications

References 26 publications

Microfluidic Assisted Synthesis of Multipurpose Polymer Nanoassembly Particles for Fluorescence, LSPR, and SERS Activities

Microfluidic Assisted Synthesis of Multipurpose Polymer Nanoassembly Particles for Fluorescence, LSPR, and SERS Activities

Synthesis of polymer particles and capsules employing microfluidic techniques

Engineering Polymer Microparticles by Droplet Microfluidics

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