Polyacrylic Acid Modifies Local and Lateral Mobilities in Lipid Membranes

Munavirov, Bulat; Филиппов, А. В.; Rudakova, Maya; Antzutkin, Oleg N.

doi:10.1080/01932691.2013.823096

Cited by 8 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DSC diagram shows an endothermic peak at 147 o C, which represents the loss of crystalline water [16,17]. At 209.8 o C an acute endothermic peak appears, which is consistent with literature data [10,11,13,15,[18][19][20] suggesting that at approximately 200-225 °C, the β-lactose portion in the molecule melts. After this endothermic phenomenon, thermal decomposition of -lactose follows, which is characterized as caramelization.…”

Section: Dsc Curves Of Pure Excipientssupporting

confidence: 90%

“…This is probably related to a solution-like model, as the presence of the copolymer rather plays a role of doping [27][28][29]. The copolymer modifies the shape and size distribution of nanoclusters-nanodomains, since it probably penetrates the interior of the bilayer, making it more fluidic [19]. To the best of our knowledge this is the first report in literature, where DSC is used for quantification of interactions of furosemide with chimeric liposomes.…”

Section: Dsc Curves Of Mixtures Of Liquid Crystalline Excipientsmentioning

confidence: 92%

See 1 more Smart Citation

Thermal analysis studies on the compatibility of furosemide with solid state and liquid crystalline excipients

Vlachou

Pippa

Siamidi

et al. 2020

Hem Ind

View full text Add to dashboard Cite

In the context of the present study, the thermal behavior of furosemide and the solid state excipients, sodium alginate, poly(ethylene oxide), poly(vinylpyrrolidone), lactose mono-hydrate and magnesium stearate, using Differential Scanning Calorimetry (DSC), was probed. It was found that the thermal behavior of these solid-state pharmaceutical excipients and furosemide correlates nicely with the literature relevant data. Regarding the furosemide-excipients mixtures, the DSC scans appear as a compilation of the thermal curves of each excipient. This suggests that the formulations containing these mixtures, may retain their stability over time. This information, which arises from the cooperativity of materials, their thermal stability and behavioris very helpful for the research and development of safe and effective pharmaceutical formulations. DSC experiments were also carried out with chimeric bilayers (called ?liposomes?), composed of hydrogenated soy phosphatidylcholine (HSPC) and poly(n-butylacrylate)-b-poly(acrylic acid) block copolymer with 70 % content of poly(acrylic acid (PnBA-b-PAA 30/70) with the addition of furosemide at the molar ratio of 9:0.1:1.0 in the system HSPC:PnBA-b-PAA 30/70:furosemide. Chimeric liposomal systems were characterized as ?fluid-like? by their DSC curves, which may be potentially translated as an easy way for release of furosemide from the advanced delivery system.

show abstract

Section: Dsc Curves Of Pure Excipientssupporting

confidence: 90%

Section: Dsc Curves Of Mixtures Of Liquid Crystalline Excipientsmentioning

confidence: 92%

Thermal analysis studies on the compatibility of furosemide with solid state and liquid crystalline excipients

Vlachou

Pippa

Siamidi

et al. 2020

Hem Ind

View full text Add to dashboard Cite

show abstract

“…Moreover, it was shown that the interaction of poly(acrylic acid) with lipid bilayers may destabilize those layers and make them more prone to leakage in a pH-dependent manner. This phenomenon can play an important supporting role in the endosomal escape of the structures based on PAA [ 28 , 29 , 30 , 31 , 32 ]. Nanogels bearing carboxylate groups, synthesized by a similar procedure as the one used in this work, have been demonstrated to be promising nanocarriers for certain drugs [ 33 ], oligonucleotides [ 34 ], and siRNA [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Targeted Radioisotope Carriers Based on Poly(Acrylic Acid) Nanogels

et al. 2021

View full text Add to dashboard Cite

Radiation crosslinking was employed to obtain nanocarriers based on poly(acrylic acid)—PAA—for targeted delivery of radioactive isotopes. These nanocarriers are internally crosslinked hydrophilic macromolecules—nanogels—bearing carboxylic groups to facilitate functionalization. PAA nanogels were conjugated with an engineered bombesin-derivative—oligopeptide combined with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate chelating moiety, aimed to provide selective radioligand transport. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) toluene-4-sulfonate was used as the coupling agent. After tests on a model amine—p-toluidine—both commercial and home-synthesized DOTA-bombesin were successfully coupled to the nanogels and the obtained products were characterized. The radiolabeling efficiency of nanocarriers with 177Lu, was chromatographically tested. The results provide a proof of concept for the synthesis of radiation-synthesized nanogel-based radioisotope nanocarriers for theranostic applications.

show abstract

“…Application of polymers undoubtedly offers a variety of advantages which, apart from drug delivery systems, allow its Radiation synthesis of poly(acrylic acid) nanogels for drug delivery applications -post-synthesis product colloidal stability application in other medical fi elds such as medical diagnostics and imaging [7]. Munavirov et al [8] claimed that poly(acrylic acid) (PAA), one of the most widely investigated biocompatible polymers, is a promising material to be used, especially in biomedicine, and its applicability is recently becoming prominent [9][10][11][12][13]. Attractiveness of PAA is strictly connected to the presence of carboxylic groups in the polymer structure [14].…”

Section: Introductionmentioning

confidence: 99%

“…Attractiveness of PAA is strictly connected to the presence of carboxylic groups in the polymer structure [14]. These groups are mainly responsible for its strong association with water and sensitivity of the material to the pH and ionic strength changes [8,14]. Moreover, their presence enables convenient bioconjugation as well as interaction with other polymeric compounds, leading to formation of relatively stable polymeric nanocomplexes [15,16].…”

Section: Introductionmentioning

confidence: 99%

Radiation synthesis of poly(acrylic acid) nanogels for drug delivery applications – post-synthesis product colloidal stability

et al. 2021

View full text Add to dashboard Cite

Synthesis of polymer nanogels (NGs) for biomedical applications is considered to be a very promising application in radiation engineering. Under high-dose pulse irradiation of dilute aqueous polymer solution, reactive species generated by water radiolysis can create multiple radicals on each macromolecule and consequently induce intramolecular cross-linking of polymer chains, resulting in NG formation. The obtained products are free from harmful monomers, initiators, and cross-linking agents, which makes them potentially applicable for drug delivery applications. One of the biggest challenges in handling and use of nanoparticles, however, is the colloidal stability, when aqueous suspensions are stored for prolonged periods. Therefore, development of the best protocols for the particular nanocarrier storage is key. To address this need, we have performed the prospective study in which we systematically assessed the influence of various processing and storage scenarios feasible in our lab, on the colloidal stability of the radiation-synthesized poly(acrylic acid) (PAA) NG particles in suspension. This allowed us to choose the optimal way of handling the product after its synthesis. We confirmed that none of the strategies we used and tested are substantially detrimental to our product. Filtration with 0.2-μm filters was proven sufficient for sample purification and prolonged storage in aqueous suspension did not exert a negative effect on the colloidal stability of particles suspension. We have also demonstrated that lyoprotectant-free lyophilization was suitable for our polymer nanoparticles. This is an important fact for further application of particles as nanocarriers for biologically active compounds such as targeting ligands or therapeutic moieties.

show abstract

Polyacrylic Acid Modifies Local and Lateral Mobilities in Lipid Membranes

Cited by 8 publications

References 41 publications

Thermal analysis studies on the compatibility of furosemide with solid state and liquid crystalline excipients

Thermal analysis studies on the compatibility of furosemide with solid state and liquid crystalline excipients

Synthesis and Properties of Targeted Radioisotope Carriers Based on Poly(Acrylic Acid) Nanogels

Radiation synthesis of poly(acrylic acid) nanogels for drug delivery applications – post-synthesis product colloidal stability

Contact Info

Product

Resources

About