Polyagglutinable Erythrocytes Associated with
Bacteriogenic Transfusion Reactions

Chorpenning, F.W.; Dodd, M.C.

doi:10.1159/000465027

Cited by 6 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacteriogenic polyagglutina tion occurs when bacteria or their products are adherent to the erythro cyte surface so that the erythrocytes are agglutinated by sera which con tain specific antibacterial antibody [9]. In many examples there is direct agglutination of the erythrocytes; in others, erythrocytes are not directly agglutinated but give positive antiglobulin tests, which demonstrate that antibacterial antibody has combined with bacteria adherent to the ery- throcyte [21].…”

Section: Microbial Poly Agglutinationmentioning

confidence: 99%

Membrane Abnormalities in Polyagglutinable Erythrocytes

Bird¹

1972

Acta Haematol

View full text Add to dashboard Cite

Polyagglutinable erythrocytes cause difficulty and delay in blood grouping and crossmatching. Abnormality of the erythrocyte membrane is the fundamental cause of some types of polyagglutinability. The altered chemical structure of the red cell membrane in various forms of polyagglutination isdescribed, with particular reference to the application of seed agglutinins in the classification of erythrocyte polyagglutinability. T-, Tn- and Cad-polyagglutination receive special attention and the ‘acquired B’ state is discussed. The haematological features of Tn-polyagglutination are also described.

show abstract

Section: Microbial Poly Agglutinationmentioning

confidence: 99%

Membrane Abnormalities in Polyagglutinable Erythrocytes

Bird¹

1972

Acta Haematol

View full text Add to dashboard Cite

show abstract

“…60 Numerous additional cases, all of transient in vivo poly-or panagglutinability as well as hemolysis of human red blood cells have been described. 11.12.24,31,62…”

mentioning

confidence: 99%

Precursors of the Blood Group MN Antigens as Human Carcinoma‐Associated Antigens

et al. 1979

View full text Add to dashboard Cite

“…The teichoic acids are important constituents of gram-positive bacterial cells (1,2) and exhibit significant biological activity (19). For example, they produce natural delayed hypersensitivity in animals (4, 14) and humans (21), nephritis in rabbits (14), experimental arthritis (26), and hemolytic episodes (8). In addition, immunoglobulin G (IgG) antibodies of teichoic acid (TA) specificity are associated with staphylococcal endocarditis (12) and rheumatic fever (3).…”

mentioning

confidence: 99%

Immunogenicity of Soluble Versus Cellular Glycerol Teichoic Acid

et al. 1979

View full text Add to dashboard Cite

Guinea pigs which were injected with either whole bacilli or purified soluble glycerol teichoic acid (GTA) usually exhibited a rise in hemolysin titer to GTAcoated erythrocytes. The only exceptions were those animals having high baseline titers of natural anti-GTA antibodies. Rats yielded better responses than guinea pigs and produced significantly higher responses to the soluble antigen than to the cellular GTA. Rats reared on a GTA-free diet were predominantly free of natural antibodies to GTA and furnished a more clear-cut model for assaying immune responses. Using this model, it was shown that adsorption of GTA to homologous erythrocytes before injection resulted in poor responses, suggesting that such spontaneous adsorption does not account for the good responses to soluble antigen. In GTA-deprived rats, positive skin tests were induced only with bacilli, whereas migration inhibitory factor was induced with both bacilli and soluble antigen. Hemolytic plaques in immunized rats were increased over controls with both kinds of immunogen, but the GTA-deprived rats responded better than conventional ones, and hemolytic plaque responses to bacilli were better than those to soluble antigen. This reversal of the serum hemolysin results may be due to delayed suppression by soluble GTA or to antibody cycling. The guinea pig data, combined with results from GTA-deprived rats, suggest that high antibody levels resulted in depressed antibody synthesis, perhaps because antibody cycling was initiated. No evidence was found to explain the superior responses to soluble antigen, but it did not seem related to formation of immune complexes or adsorption to erythrocyte membranes.

show abstract

Polyagglutinable Erythrocytes Associated with Bacteriogenic Transfusion Reactions

Cited by 6 publications

References 7 publications

Membrane Abnormalities in Polyagglutinable Erythrocytes

Membrane Abnormalities in Polyagglutinable Erythrocytes

Precursors of the Blood Group MN Antigens as Human Carcinoma‐Associated Antigens

Immunogenicity of Soluble Versus Cellular Glycerol Teichoic Acid

Contact Info

Product

Resources

About