Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients

Abstract

Polyamine contents were assessed by mass spectrometry in 233 current foods and beverages. In order to reduce gut polyamine uptake, a polyamine reduced diet (PRD) and partial intermittent intestinal tract decontamination (PIITD) with neomycin or nifuroxazide was proposed as nutritional therapy to 33 prostate carcinoma patients, 30 of whom with hormone refractory prostate cancer (HRPC). Mean PRD observance was 22 +/- 19 (median: 16; range: 3-72) months. 10, 8 and 3 patients were respectively on PRD for more than 30, 36 and 64 months. No diet toxicity was observed. 8 patients had moderate intestinal intolerance due to PIITD which was interrupted. No significant differences in body weight, blood counts or serum protein levels were observed during the follow-up of patients under PRD. Performance status and pain scores were relatively stable during the trial with improved pain scores at 6 months. A PRD associated with intermittent PIITD is a safe and well observed nutritional regimen and long term observance is possible.

Catalytically active bovine serum amine oxidase bound to fluorescent and magnetically drivable nanoparticles

“…As previously shown by Bardocz et al, 43 some food ingredients contain large quantities of polyamines and preliminary clinical trials performed in metastatic hormone-refractory prostate cancer patients have revealed the feasibility of a nutrition therapy based upon a 6-month polyamine-reduced diet. 44,45 In conclusion, it is worth pointing out that the production process is very cheap and, by not involving organic solvents surfactants or particular capping strategies, it can be considered a "green chemistry" product. Nevertheless, the favorable magnetic properties of the material are guaranteed by optimizing the magnetic material/organic shell ratio.…”

Biological Effects of Polyamines on the Prevention of Aging-associated Diseases and on Lifespan Extension

“…The foods that have a close relationship with an increased incidence of aging-associated diseases include Western desserts made from butter, cream, milk, egg, sugar, and animal fats that contain little polyamines (B. G. Cipolla et al, 2007;Nishibori et al, 2006;Nishimura et al, 2006;Soda, 2012).…”

Dietary Polyamines and Diseases: Reducing Polyamine Intake Can Be Beneficial In Cancer Treatment

“…A polyamine blocker therapy applied to explore the role of tumor-associated polyamines as immunosuppressive metabolites in oncogenesis and tumor progression and resulted that the applied therapy did not only block tumor growth but also promoted anticancer immune responses [79]. In prostate cancer patients it was shown that the reduction of dietary polyamine intake and partial intestinal decontamination was beneficial for patient quality of life and pain control [80].…”

“…Moreover, dietary putrescine reduced the ability of sulindac to suppress intestinal tumorigenesis in the mouse model suggesting that reducing polyamine metabolism and dietary polyamine levels might enhance strategies for colon cancer chemoprevention [42]. Consuming low polyamine diet and reducing bacterial gut production improved performance status and pain control in hormone refractory prostate cancer patients [80,89]. The association between high dietary polyamine intake and risk of colorectal adenoma was provided in literature [90,91].…”