Polyamine-Enriched Exosomes from Leishmania donovani Drive Host Macrophage Polarization via Immunometabolism Reprogramming
Prince Sebastian,
Madhulika Namdeo,
Moodu Devender
et al.
Abstract:Leishmania donovani (Ld) promastigotes secrete exosomes that are crucial in host−pathogen interactions and intercellular communication by carrying parasite-specific molecules. Although the composition of cargos in Leishmania exosomes is known, the effects of the unique metabolic repertoire on immunometabolism rewiring of macrophage polarization are poorly understood. Interestingly, we found the enrichment of polyamines (PAs) such as spermidine and putrescine in the Ldexosomes. Herein, we investigate the critic… Show more
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