Polyamine-polyamine oxidase interaction: part of maternal protective mechanism against fetal rejection.

Morgan, David M. L.; Illei, G

doi:10.1136/bmj.280.6227.1295

Cited by 31 publications

(17 citation statements)

References 29 publications

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“…DAO had been suggested to be involved in the production of immuno-suppressive factors which act locally at the materno-placental interface to suppress lymphocyte reactivity and hence protect the feto-placental allograft from immune rejection. This originates from the observation that the polyamines, spermine and spermidine reversibly suppress mitogen-stimulated lymphocyte proliferation in the presence of fetal calf serum or retro-placental pregnancy serum containing polyamine oxidase (Byrd etal., 1977;Gaugas and Curzen, 1978;Morgan and Illei, 1980). The mechanism by which the products of polyamine oxidation inhibit lymphocyte proliferation without a direct cytotoxic effect is unknown, although they have been suggested to act on the cell membrane rather than intra-cellularly (see Illei and Morgan, 1979).…”

Section: Scbeumentioning

confidence: 96%

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Bell

1986

Human Reproduction

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In contrast to our ability to monitor placental function during pregnancy, due to the availability of a range of placentally derived secretory products such as HCG, HPL, SP1, PAPP-A, etc. the equivalent monitoring of the endometrial function in implantation and pregnancy has been impaired by a lack of equivalent endometrial products. Decidual diamine oxidase and prolactin have been extensively characterized but each have clinical drawbacks and may indeed be minor products of the endometrium. Recent developments in the characterization of the major secretory protein products of the endometrium, and a re-assessment of the origin of a number of placental proteins, radically alter our ability to monitor endometrial function, offer a new clinical window on pregnancy and might provide new knowledge on the extent of feto-maternal dialogue at implantation and during pregnancy. In this review, aspects of many scientific studies, and the function and possible clinical significance of these endometrial and decidual protein products are assessed.

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Section: Scbeumentioning

confidence: 96%

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Bell

1986

Human Reproduction

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“…Spermine and spermidine serve to suppress the lymphocyte proliferation in vitro and believed to also inhibit the release of inflammatory mediators [5]. Spermine is rich in placenta and reacts with serum polyamine oxidase to form aldehydes that inhibit lymphocyte proliferation to avoid fetal rejection [6]. Pregnancy serum contains higher polyamine oxidase to produce these aldehydes and works as immunoregulatory factor to escape abortion [7].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of polyamines in serotonin and carrageenan paw edemata—possible mechanism to increase vascular permeability inhibitory protein level which is regulated by glucocorticoids and superoxide radical

Òyanagui

1984

Agents and Actions

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Serotonin paw edema of mice and carrageenan paw edema of rats were inhibited by subcutaneously or orally administered certain polyamines. They must be given at least 2 h before serotonin challenge to get inhibitions which were blocked by the concomitant injections of cycloheximide. Thirty percent inhibitory dose (ID30) of polyamines (s.c.) 3 h before serotonin (s.c.) were: spermidine (8 mg/kg), spermine 28 mg/kg) and putrescine (55 mg/kg). Agmatine, cadaverine, ornithine, citrulline, lysine and arginine were not inhibitory even at 200 mg/kg. Three inhibitory polyamines were effective by oral administration but were not inhibitory by local administration into the paws. Intravenous injections of spermidine also required 2 h of lag period for inhibitions. Serotonin edema was inhibited by dexamethasone (1 mg/kg), prednisolone (1 mg/kg) or by superoxide dismutase (SOD, 5 mg/kg) in lag period requiring manner (s.c. and i.v.). High dose of cyclo-oxygenase inhibitors indomethacin and diclofenac sodium, lipo-oxygenase inhibitor BW755C (30 mg/kg s.c., respectively) and phospholipase A2 inhibitor quinacrine (100 mg/kg s.c.) failed to inhibit serotonin edema, suggesting that arachidonate metabolites are not participating in this model. ID30 of polyamines which were administered (s.c. and oral) to rats 3 h before carrageenan and determined at 3 h by paw weight were: spermidine (28 and 100 mg/kg), spermine (18 and 90 mg/kg) and putrescine (both greater than 200 mg/kg). Adrenalectomized rats responded to polyamines just as normal rats. Local vascular permeability, irritancy and acute toxicity were also tested in mice. Polyamines were proved to be glucocorticoid-type anti-inflammatory drugs. Polyamines may be mediators of glucocorticoids for the synthesis of the postulated vascular permeability inhibitory protein (called as 'vasoregulin' for convenience). Anti-inflammatory effect of glucocorticoid is recently explained by its capacity to induce phospholipase A2 inhibitory protein(s) (macrocortin or lipomodulin). However, this hypothesis has not yet been proved by in vivo experiment and our data suggest that there is induction by glucocorticoid of another kind of protein which does not inhibit phospholipase A2 activity.

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“…The interaction of polyamine oxidase with substrate is a part of maternal protective mechanism against fetal rejection. The increase of polyamine oxidase activity during the pregnancy, observed in our investigation, might have an immunoregulatory function in the placental bed, which might contribute to the protection of the fetoplacental unit from possible maternal immune rejection [26]. Also, the observed PAO activity changes in amniotic fluid may reflect the polyamine synthesis rate and the metabolic activity in human placenta during pregnancy.…”

Section: Discussionmentioning

confidence: 77%

“…Polyamine oxidase (PAO) catalyzes the oxidative deamination of spermine (Sp) or spermidine (Spd), producing spermidine or putrescine depending of substrate nature [21][22][23][24]. It is well documented that serum PAO activity increases in pregnancy [25], [26]. DAO, histaminase (EC, 1.4.3.6), a copper-containing enzyme catalyses the oxidation of diamine putrescine or histamine, producing GABA or MDA [27], [28].…”

Section: Introductionmentioning

confidence: 99%

Enzymes of polyamine biodegradation pathway in amniotic fluid during the pregnancy compared with values of L/S ratio

Bjelaković

Pavlović²,

Kocic³

et al. 2015

IJBAS

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Background: During the pregnancy the amount of polyamines spermine, spermidine and putrescine, rise rapidly in amniotic fluid. Polyamine oxidase (PAO) represents one of the key enzymes in catabolic pathway of polyamines. PAO catalyzes the oxidative deamination of spermine (Sp) or spermidine (Spd). The literature data documented that serum PAO activity increases in pregnancy. Diamine oxidase (DAO), histaminase, catalyses the oxidation of diamine putrescine or histamine. DAO is present in high concentrations in amniotic fluid. Amniotic fluid is the protective liquid for the baby in the mother's uterus. The determination of the lecithin to sphyngomyelin (L/S) ratio is by far the most widely used and accepted method to assess the fetal lung immaturity. The idea of the present study was to elucidate the polyamine metabolism in amniotic fluid during the pregnancy, through investigation of polyamine oxidase (PAO) and diamine oxidase (DAO) activities, and to compare their activities with the values of lecithin/ sphingomielin ratio (L/S) ratio. Methods: The study included 170 pregnant women. The amniotic fluid samples were obtained using amniocentesis. The values of L/S ratio were estimated by a thin layer chromatography. PAO and DAO activities were measured by the spectrophotometric methods. Results: Our results confirmed that amniotic fluid possess PAO and DAO activity. The activities of both enzymes in amniotic fluid samples increase in parallel with the L/S ratio increase. Diamine oxidase activity was higher than polyamine oxidase activity. Conclusions: DAO and PAO activities may serve as markers of fetal lung maturity.

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Polyamine-polyamine oxidase interaction: part of maternal protective mechanism against fetal rejection.

Cited by 31 publications

References 29 publications

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Anti-inflammatory effect of polyamines in serotonin and carrageenan paw edemata—possible mechanism to increase vascular permeability inhibitory protein level which is regulated by glucocorticoids and superoxide radical

Enzymes of polyamine biodegradation pathway in amniotic fluid during the pregnancy compared with values of L/S ratio

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