Polyamine-reduced diet in metastatic hormone-refractory prostate cancer (HRPC) patients

Cipolla, B.; Guilhot, François; Moulinoux, Jacques-Philippe

doi:10.1042/bst0310384

Cited by 41 publications

(15 citation statements)

References 15 publications

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“…Even without considering the difference in metabolic rates between mice and humans, our results suggest that certain sources of dietary putrescine could reach levels capable of modifying sulindac responses in humans. Our data add to the growing recognition of the potential importance of dietary polyamines for their effects on cancer progression (52,53). (A) Effect of sulindac on steady-state levels of spermidine/spermine N 1 -acetyltransferase (SSAT) RNA in the small intestine of wild-type Apc (Apc +/+ ) and Apc Min/+ mice.…”

Section: Discussionmentioning

confidence: 99%

Dietary Putrescine Reduces the Intestinal Anticarcinogenic Activity of Sulindac in a Murine Model of Familial Adenomatous Polyposis

Ignatenko¹,

Besselsen²,

Roy³

et al. 2006

Nutrition and Cancer

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The nonsteroidal antiinflammatory drug sulindac displays chemopreventive activity in patients with familial adenomatous polyposis (FAP). Sulindac metabolites induce apoptosis in colon tumor cells, in part, by a polyamine-dependent mechanism that can be suppressed with exogenous putrescine. To determine the relevance of this mechanism in animals, we treated Apc Min/+ mice, a model of human FAP, with sulindac alone or in combination with dietary putrescine. Sulindac increased steady-state RNA levels and enzymatic activity of the polyamine catabolic enzyme spermidine/spermine N 1 -acetyltransferase and intestinal levels of monoacetylspermidine, spermidine, and spermine in the small intestine of mice. Sulindac also decreased the activity of the biosynthetic enzyme ornithine decarboxylase but not adenosylmethionine decarboxylase (AMD).

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Section: Discussionmentioning

confidence: 99%

Dietary Putrescine Reduces the Intestinal Anticarcinogenic Activity of Sulindac in a Murine Model of Familial Adenomatous Polyposis

Ignatenko¹,

Besselsen²,

Roy³

et al. 2006

Nutrition and Cancer

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“…Animal models have shown that polyamine deficient chow, along with concomitant administration of inhibitors of polyamine synthesis and/or antibiotics that suppress intestinal flora, lowers overall blood polyamine concentrations ( 6 ). In patients with malignancies, whose blood polyamine levels are often increased, reduced polyamine intake decreases blood polyamine concentration ( 10 ).…”

mentioning

confidence: 99%

Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations

Soda

Kano

Sakuragi

et al. 2009

J Nutr Sci Vitaminol

132

105

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Summary Although the intracellular de novo synthesis of the polyamines decreases with age, there is no similar trend in blood polyamine levels, but rather there is wide individual variability. We hypothesized that dietary polyamines attenuate a decrease in blood polyamine levels with age and augment the previously observed individual variability. The effect of a polyamine rich diet, in both mice and humans, on blood polyamine concentrations was examined in this study. Jc1:ICR male mice were fed test diets containing 3 different polyamine concentrations. Healthy human male volunteers added 50 to 100 g of the polyamine-rich fermented soybean product, natto, to their daily intake. After 26 wk, the mean blood spermine concentration in mice receiving the test diet with high polyamine concentrations was 10.1 Ϯ 2.4 mol/L, while the mean concentrations found in mice fed with a diet with normal or low polyamine concentrations were 5.2 Ϯ 0.9 and 4.7 Ϯ 0.5 mol/L, respectively ( p Ͻ 0.05). A mean daily intake of 66.4 Ϯ 3.7 g (range ϭ 46.4-89.3 g) of natto for 2 mo by human volunteers increased the mean blood spermine concentration by a factor of 1.39 ( n ϭ 10) ( p Ͻ 0.01), while in control volunteers ( n ϭ 7), asked to exclude polyamine-rich foods from their diet, blood spermine concentration remained unchanged. The individual variability of blood polyamine levels was enhanced after polyamine intake in mice and, to a lesser extent, in humans. The long-term oral intake of enhanced polyamine diets increases blood polyamine levels in both mice and humans.

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“…As previously shown by Bardocz et al, 43 some food ingredients contain large quantities of polyamines and preliminary clinical trials performed in metastatic hormone-refractory prostate cancer patients have revealed the feasibility of a nutrition therapy based upon a 6-month polyamine-reduced diet. 44,45 In conclusion, it is worth pointing out that the production process is very cheap and, by not involving organic solvents surfactants or particular capping strategies, it can be considered a "green chemistry" product. Nevertheless, the favorable magnetic properties of the material are guaranteed by optimizing the magnetic material/organic shell ratio.…”

Section: Discussionmentioning

confidence: 99%

Catalytically active bovine serum amine oxidase bound to fluorescent and magnetically drivable nanoparticles

Sinigaglia¹,

Magro²,

Miotto³

et al. 2012

IJN

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Novel superparamagnetic surface-active maghemite nanoparticles (SAMNs) characterized by a diameter of 10 ± 2 nm were modified with bovine serum amine oxidase, which used rhodamine B isothiocyanate (RITC) adduct as a fluorescent spacer-arm. A fluorescent and magnetically drivable adduct comprised of bovine serum copper-containing amine oxidase (SAMN-RITC-BSAO) that immobilized on the surface of specifically functionalized magnetic nanoparticles was developed. The multifunctional nanomaterial was characterized using transmission electron microscopy, infrared spectroscopy, mass spectrometry, and activity measurements. The results of this study demonstrated that bare magnetic nanoparticles form stable colloidal suspensions in aqueous solutions. The maximum binding capacity of bovine serum amine oxidase was approximately 6.4 mg g -1 nanoparticles. The immobilization procedure reduced the catalytic activity of the native enzyme to 30% ± 10% and the Michaelis constant was increased by a factor of 2. We suggest that the SAMN-RITC-BSAO complex, characterized by a specific activity of 0.81 IU g -1, could be used in the presence of polyamines to create a fluorescent magnetically drivable H 2 O 2 and aldehydes-producing system. Selective tumor cell destruction is suggested as a potential future application of this system.

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Polyamine-reduced diet in metastatic hormone-refractory prostate cancer (HRPC) patients

Cited by 41 publications

References 15 publications

Dietary Putrescine Reduces the Intestinal Anticarcinogenic Activity of Sulindac in a Murine Model of Familial Adenomatous Polyposis

Dietary Putrescine Reduces the Intestinal Anticarcinogenic Activity of Sulindac in a Murine Model of Familial Adenomatous Polyposis

Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations

Catalytically active bovine serum amine oxidase bound to fluorescent and magnetically drivable nanoparticles

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