Polyamines and Prostatic
Carcinoma: Clinical and
Therapeutic Implications

Cipolla, B.; Guilhot, François; Jp, Moulinoux; Quemener,; Staerman, F.; Corbel, L.; Lobel, Bernard

doi:10.1159/000474279

Cited by 31 publications

(18 citation statements)

References 15 publications

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“…As we discussed previously, the natural polyamines, putrescine, spermine and spermidine are ubiquitous molecules; however, their requirements are particularly high in rapidly growing tissues during normal growth and development, and in tumors [37,216,217,218]. Several reports have described increased polyamine levels in the blood and/or urine of cancer patients [219,220,221,222,223] and elevated levels correlate with more advanced disease and worse prognosis [216,224,225,226,227]. Increased polyamine levels are associated with increased cell proliferation, decreased apoptosis and increased expression of genes affecting tumor invasion and metastasis [37,228].…”

Section: Therapeutic Approaches To Prostate Cancer: Targeting the mentioning

confidence: 99%

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One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

Corbin

Ruiz-Echevarría

2016

IJMS

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Cancer cell metabolism differs significantly from the metabolism of non-transformed cells. This altered metabolic reprogramming mediates changes in the uptake and use of nutrients that permit high rates of proliferation, growth, and survival. The androgen receptor (AR) plays an essential role in the establishment and progression of prostate cancer (PCa), and in the metabolic adaptation that takes place during this progression. In its role as a transcription factor, the AR directly affects the expression of several effectors and regulators of essential catabolic and biosynthetic pathways. Indirectly, as a modulator of the one-carbon metabolism, the AR can affect epigenetic processes, DNA metabolism, and redox balance, all of which are important factors in tumorigenesis. In this review, we focus on the role of AR-signaling on one-carbon metabolism in tumorigenesis. Clinical implications of one-carbon metabolism and AR-targeted therapies for PCa are discussed in this context.

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Section: Therapeutic Approaches To Prostate Cancer: Targeting the mentioning

confidence: 99%

“…Changes in polyamine levels have been reported in PCa [143,218,225,229,230,231]. Underscoring the clinical relevance of polyamines to prostate cancer, preclinical data suggest that inhibition of polyamine synthesis blocks the progression of the disease [232,233,234,235,236,237].…”

Section: Therapeutic Approaches To Prostate Cancer: Targeting the mentioning

confidence: 99%

One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

Corbin

Ruiz-Echevarría

2016

IJMS

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“…The biological association between increased polyamines and tumor formation is well established in numerous cancers including breast, prostate, colon, skin carcinoma and neuroblastoma (Cipolla et al, 1993; Leveque et al, 2000; Thomas and Thomas, 2003; Gerner and Meyskens, 2004; Casero and Marton, 2007). There is also evidence that increased polyamine biosynthesis is not just a consequence of increased proliferation in these cells, but may be necessary for the development of specific cancers (Gerner and Meyskens, 2004; Casero and Marton, 2007).…”

Section: Aberrant Expression Within the Polyamine Pathway In Neuroblamentioning

confidence: 99%

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

Gamble¹,

Hogarty²,

Liu³

et al. 2012

Front. Oncol.

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Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that up-regulation of polyamine pro-synthetic enzymes and down-regulation of catabolic enzymes is associated with poor prognosis. Polyamine sufficiency may be required for MYCN oncogenicity in MYCN amplified neuroblastoma, and targeting polyamine homeostasis may therefore provide an attractive therapeutic approach. ODC1, an oncogenic MYCN target, is rate-limiting for polyamine synthesis, and is overexpressed in many cancers including neuroblastoma. Inhibition of ODC1 by difluoromethylornithine (DFMO) decreased tumor penetrance in TH-MYCN mice treated pre-emptively, and extended survival and synergized with chemotherapy in treating established tumors in both TH-MYCN and xenograft models. Efforts to augment DFMO activity, or otherwise maximally reduce polyamine levels, are focused on antagonizing polyamine uptake or augmenting polyamine export or catabolism. Since polyamine inhibition appears to be clinically well tolerated, these approaches, particularly when combined with chemotherapy, have great potential for improving neuroblastoma outcome in both MYCN amplified and non-MYCN amplified neuroblastomas.

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“…KALAC & KRAUSOVÁ (2005) relatam que ovos inteiros cozidos apresentaram baixos teores das três poliaminas analisadas, sendo permitido em dietas de pacientes com câncer de próstata (CIPOLLA et al, 1993).…”

Section: Resultsunclassified