Polyamines in mammalian ageing: An oncological problem, too? A review

Scalabrino, Giuseppe; Ferioli, Maria Elena

doi:10.1016/0047-6374(84)90090-3

Cited by 80 publications

(48 citation statements)

References 52 publications

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“…Spermidine plays an important role in ageing during which there is a decline of its levels in different mammalian organs (Scalabrino and Ferioli 1984). The exogenous administration of spermidine promotes longevity in many model organisms including yeast, nematodes and flies, and significantly reduces age-related oxidative protein damage in mice (Eisenberg et al 2009;Madeo et al 2010;Morselli et al 2011;Tirupathi et al 2011).…”

Section: Discussionmentioning

confidence: 99%

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A

et al. 2014

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Section: Discussionmentioning

confidence: 99%

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A

et al. 2014

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“…Polyamines (PAs) can be rightly included in the large family of growth factors not identified as hormones. When normal eukaryotic cells become differentiated and/or senescent, the biosynthesis of PAs progressively decreases (Scalabrino & Ferioli, 1984), whereas embryo development and plant meristems, which are in active and rapid proliferation, as well as tumor growth, have a strikingly elevated PA content and biosynthesis (Bagni & Serafini-Fracassini, 1978;Janne, Poso & Raina, 1978). The absolute cell requirement for PAs for continued proliferation has also been demonstrated using the genetic approach.…”

Section: Introductionmentioning

confidence: 99%

The plant cell wall is altered by inhibition of polyamine biosynthesis

et al. 1997

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SUMMARYPolyamines (PAs) and the cell wall have important roles in plant morphogenesis. An interaction between cell wall components (pectic substances) and poiyamines is known and inhibition of polyamine biosynthesis induces . inhibition of some morphogenic processes. This is the case of rhizogenesis in tobacco {Nicotiana tabacum L.) thin layers. This paper investigates whether inhibition of polyamine biosynthesis induces modifications in the structure, shape and size of the primary cell walls in tobacco thin layers cultured on a rhizogenic medium, and whether polyamines (putrescine and spermidine) administered in combination with their corresponding inhibitors DL-a-difluoromethylornithine + DL-a-difluoromethyiarginine (DFMO + DFMA), cyclohexylamine (CHA), methylglyoxai-bis(guanylhydrazone) (MGBG) restore cell wall characteristics. In treatments with polyamine inhibitors, cell hypertrophy occurred in the lowermost layer of the explant in contact wdth the medium. Many unusual features were observed in the walls of the hypertrophic cells: an amorphous structure, loosening of the fibrillar component; detachment between contiguous cells, lysis of wall components and an uneven thickness often giving a wavy appearance (in transverse walls). The inhibitors reduced cell wall thickness, and caused a weak positive PATAg reaction for polysaccharides. Polyamines restored cell wall thickness and, in general, the other wall features. Our results show that polyamines are necessary for maintaining cell w^all characteristics by strengthening the links between cell-wall components.

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“…Nevertheless, one commonality is that tissue concentrations of spermidine decline in an age-dependent manner in both model organisms and humans [7,9,26,27]. This may account for decreased autophagy and drive the onset of age-associated diseases.…”

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confidence: 99%

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

et al. 2018

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Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.

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Polyamines in mammalian ageing: An oncological problem, too? A review

Cited by 80 publications

References 52 publications

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A

The plant cell wall is altered by inhibition of polyamine biosynthesis

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

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