Polyampholyte Hydrogels in Biomedical Applications

Haag, Stephanie L.; Bernards, Matthew T.

doi:10.3390/gels3040041

Cited by 48 publications

(30 citation statements)

References 63 publications

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“…After removing of the template a cavity with a complementary shape and selective recognition properties to template molecules is maintained [159]. The stimuli sensitive ability of MIP networks to switch on/off the affinity of the networks for the imprinted molecules by fine-tuning of temperature, pH, and ionic strength is promising for biomedical applications [160,161]. Thus at the IEP of polyampholyte dendrimer the detachment of amphoteric macromolecules from the gel matrix of polyelectrolytes takes place.…”

Section: Methodsmentioning

confidence: 99%

Intra- and Interpolyelectrolyte Complexes of Polyampholytes

Kudaibergenov

Nuraje

2018

Preprint

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At present, a large amount of research works from experimental and theoretical points of view have been done on interpolyelectrolyte complexes formed by electrostatic interactions and/or interpolymer complexes stabilized by hydrogen bonds. On the contrary, relatively less attention has been given to polymer-polymer complex formation with synthetic polyampholytes. In this review the complexation of polyampholytes with polyelectrolytes is considered from theoretical and application points of view. Formation of intra- and interpolyelectrolyte complexes of random, regular, block, dendritic polyampholytes are outlined. The separate subchapter is devoted to amphoteric behavior of interpolyelectrolyte complexes. The realization of so-called “isoelectric effect” for interpolyelectrolyte complexes of water-soluble polyampholytes, amphoteric hydrogels and cryogels with respect to surfactants, dye molecules, polyelectrolytes and proteins is demonstrated.

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Section: Methodsmentioning

confidence: 99%

Intra- and Interpolyelectrolyte Complexes of Polyampholytes

Kudaibergenov

Nuraje

2018

Preprint

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“…Chitosan, as a positively charged polymer, willingly interacts with anionic molecules (phosphate salts, carboxylate salts) and creates polyelectrolyte complexes with polysaccharides (e.g., pectin, dextran, carboxymethyl cellulose, hyaluronic acid) and proteins (e.g., gelatin), as well as synthetic polymers, e.g., poly(acrylic acid) [ 36 , 43 , 46 ]. The ionically bonded hydrogels prepared from ampholytic polymers, e.g., proteins, poly(acrylamide), and poly(methacrylate) derivatives, have also been investigated [ 43 , 47 , 48 , 49 ]. The ionic interactions are present in many different systems and very often stabilize hydrogel structure, cooperating with other types of interactions.…”

Section: Interactions In Supramolecular Hydrogelsmentioning

confidence: 99%

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Skopińska-Wiśniewska

Flor

Kozłowska

2021

IJMS

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Supramolecular hydrogels are 3D, elastic, water-swelled materials that are held together by reversible, non-covalent interactions, such as hydrogen bonds, hydrophobic, ionic, host–guest interactions, and metal–ligand coordination. These interactions determine the hydrogels’ unique properties: mechanical strength; stretchability; injectability; ability to self-heal; shear-thinning; and sensitivity to stimuli, e.g., pH, temperature, the presence of ions, and other chemical substances. For this reason, supramolecular hydrogels have attracted considerable attention as carriers for active substance delivery systems. In this paper, we focused on the various types of non-covalent interactions. The hydrogen bonds, hydrophobic, ionic, coordination, and host–guest interactions between hydrogel components have been described. We also provided an overview of the recent studies on supramolecular hydrogel applications, such as cancer therapy, anti-inflammatory gels, antimicrobial activity, controlled gene drug delivery, and tissue engineering.

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“…Molecularly imprinted polyampholyte (MIP) hydrogels and cryogels [43,44,45,46] are promising materials for biomedical applications [47,48,49]. Macroporous amphoteric polymers based on N -[3-(dimethylamino)propyl]methacrylate and MAA [46] and N , N -dimethylaminopropylacrylamide and allylamine (AA) [50] were used as a templates, adsorbents and carriers with respect to bovine serum albumin (BSA) [50] and lysozyme [46].…”

Section: Complexation Of Polyampholyte Cryogels With Transition Mementioning

confidence: 99%

Physicochemical, Complexation and Catalytic Properties of Polyampholyte Cryogels

Kudaibergenov

2019

Gels

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Polyampholyte cryogels are a less considered subject in comparison with cryogels based on nonionic, anionic and cationic precursors. This review is devoted to physicochemical behavior, complexation ability and catalytic properties of cryogels based on amphoteric macromolecules. Polyampholyte cryogels are able to exhibit the stimuli-responsive behavior and change the structure and morphology in response to temperature, pH of the medium, ionic strength and water–organic solvents. Moreover, they can uptake transition metal ions, anionic and cationic dyes, ionic surfactants, polyelectrolytes, proteins, and enzymes through formation of coordination bonds, hydrogen bonds, and electrostatic forces. The catalytic properties of polyampholyte cryogels themselves and with immobilized metal nanoparticles suspended are outlined following hydrolysis, transesterification, hydrogenation and oxidation reactions of various substrates. Application of polyampholyte cryogels as a protein-imprinted matrix for separation and purification of biomacromolecules and for sustained release of proteins is demonstrated. Comparative analysis of the behavior of polyampholyte cryogels with nonionic, anionic and cationic precursors is given together with concluding remarks.

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Polyampholyte Hydrogels in Biomedical Applications

Cited by 48 publications

References 63 publications

Intra- and Interpolyelectrolyte Complexes of Polyampholytes

Intra- and Interpolyelectrolyte Complexes of Polyampholytes

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Physicochemical, Complexation and Catalytic Properties of Polyampholyte Cryogels

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