Polyarteritis nodosa and parvovirus B19 infection

Corman, Lourdes C.; Dolson, DavidJ.

doi:10.1016/0140-6736(92)91096-q

Cited by 112 publications

(41 citation statements)

References 7 publications

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“…There are several reports of parvovirus B 19 infection associated with vasculitis; recently, cases of polyarteritis nodosa and Kawasaki disease have been described (1,2). We report a case of Wegener's granulomatosis associated with persistent parvovirus B19 infection.…”

mentioning

confidence: 84%

Wegener's granulomatosis and parvovirus

Nikkari

Mertsola

Korvenranta

et al. 1994

Arthritis & Rheumatism

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mentioning

confidence: 84%

Wegener's granulomatosis and parvovirus

Nikkari

Mertsola

Korvenranta

et al. 1994

Arthritis & Rheumatism

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“…B19 is the causative agent of erythema infectiosum (fifth disease), hydrops fetalis, and transient aplastic anemia (1,86). Several studies disclosed an association between B19 and a variety of diseases (43,48,63,80), such as arthritis (56,77), vasculitic syndromes (19,24,31,80), hepatitis (27,36,38,75,85), and neurological disorders (2,85). Specifically, B19 infections have been observed to be associated with acute and chronic myocarditis (13,16,30,44,53,(58)(59)(60)71).…”

mentioning

confidence: 99%

Phospholipase A2 Activity-Dependent Stimulation of Ca ²⁺ Entry by Human Parvovirus B19 Capsid Protein VP1

Lupescu¹,

Bock

Lang

et al. 2006

J Virol

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Recent reports demonstrated an association of human parvovirus B19 with inflammatory cardiomyopathy (iCMP), which is accompanied by endothelial dysfunction. As intracellular Ca 2؉ activity is a key regulator of cell function and participates in mechanisms leading to endothelial dysfunction, the present experiments explored the effects of the B19 capsid proteins VP1 and VP2. A secreted phospholipase A2 (PLA2)-like activity has been located in the VP1 unique region of the B19 minor capsid protein. As PLA2 has recently been shown to activate the store-operated or capacitative Ca 2؉ channel I CRAC , we analyzed the impact of the viral PLA2 motif on Ca 2؉ entry. We cloned the VP1 and VP2 genes isolated from a patient suffering from fatal B19 iCMP into eukaryotic expression vectors. We also generated a B19 replication-competent plasmid to demonstrate PLA2 activity under the control of the complete B19 genome. After the transfection of human endothelial cells (HMEC-1), cytosolic Ca Human parvovirus B19, a nonenveloped virus of about 22 to 24 nm in diameter, is a member of the genus Erythrovirus within the family of Parvoviridae (35). B19 infection occurs frequently in humans, and this is documented by the high prevalence of specific immunoglobulin G (IgG) antibodies in young children (5% to 15%), adults (60%), and seniors older than 69 years (85%) (15). B19 is the causative agent of erythema infectiosum (fifth disease), hydrops fetalis, and transient aplastic anemia (1,86). Several studies disclosed an association between B19 and a variety of diseases (43,48,63,80), such as arthritis (56, 77), vasculitic syndromes (19, 24, 31, 80), hepatitis (27,36,38,75,85), and neurological disorders (2, 85). Specifically, B19 infections have been observed to be associated with acute and chronic myocarditis (13,16,30,44,53,(58)(59)(60)71). Moreover, the development of endothelial and isolated left ventricle diastolic dysfunction has been associated with B19 infection (81). During pregnancy, parvovirus B19 infection may cause maternal and fetal myocarditis, congenital abnormalities, stillbirth, and abortion (10, 21, 39, 61). The particularly severe course of the antenatal disease may relate to the preference of B19 for proliferating tissues (79).The cellular receptor for B19 infection has been regarded as a blood group P antigen based on the failure of B19 infection in a patient with a hereditary P antigen defect (12). The P antigen is necessary for B19 binding but not sufficient for virus entry into cells. In this regard, the ␣5␤1 integrin and the recently identified Ku80 autoantigen act as cellular coreceptors for human parvovirus B19 infection (57, 82). Therefore, target cells of B19 are mainly erythroid progenitor cells expressing high levels of P antigen as well as the coreceptors ␣5␤1 integrin and Ku80 autoantigen. However, nonerythroid cell lineages, such as fetal myocytes, follicular dendritic cells, and endothelial cells can be infected by B19 (12,28,29,57,82). We have recently localized B19 genomes in endothelial cells of my...

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“…One of the suspects for such an agent is a virus because viral infections such as rubella, human parvovirus B19 (B19), cytomegalovirus (CMV), human T cell leukemia virus 1, and HIV often cause an acute onset of polyarthritis (1)(2)(3)(4)(5). Some cases with acute B19 infection are well known to present clinical symptoms resembling RA (1)(2)(3), and the presence of B19 DNA has been demonstrated in autoimmune diseases such as RA, systemic lupus erythematosus, adult-onset Still's disease, and polyarteritis nodosa (6)(7)(8). Although the expression of B19 protein or its isolation from the affected organ is critical to know the role of the virus in vivo, these have remained unelucidated.…”

mentioning

confidence: 99%