Polyarteritis nodosa in north India: clinical manifestations and outcomes

Sharma, Aman; Pinto, Benzeeta; Dhooria, Aadhaar; Rathi, Manish; Singhal, Manphool; Dhir, Varun; Sharma, Kusum; Parkash, Mahesh; Modi, Manish; Vijayvergiya, Rajesh; Sinha, Saroj Kant; Nada, Ritambhra; Minz, Ranjana W.; Singh, Surjit

doi:10.1111/1756-185x.12954

Cited by 17 publications

(25 citation statements)

References 21 publications

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“…PAN is more common in males among adults while females are equally affected in children. [10][11][12][13][14][15] In the presented pediatric cohort there was a clear female predominance with twice as more girls being affected, and a male predominance in adult patients. However, the reason for this difference is not clear; this may be partly due to cutaneous PAN cases, which is more frequent in females.…”

Section: Discussionmentioning

confidence: 82%

“…The male/female (M/F) ratio was 0.5 in children while there was a clear male predominance in adults (M/F 4.5). The median age at disease onset was 11 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) in children and 33 (19-71) years in adults. Nineteen adult patients (86.4%) also fulfilled the Ankara 2008 criteria for PAN.…”

Section: Resultsmentioning

confidence: 99%

“…Five children with cutaneous PAN (33.3%) received only corticosteroid treatment. The median (min-max) duration for induction treatment was 3 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) months in children and 12 (3-29) months for adults. The duration of induction treatment was shorter in children in comparison with adults (P = 0.004).…”

Section: Resultsmentioning

confidence: 99%

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Comparing polyarteritis nodosa in children and adults: a single center study

et al. 2017

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Section: Discussionmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Comparing polyarteritis nodosa in children and adults: a single center study

et al. 2017

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“…The second reason is immune complexes mediating micro‐vascular diseases such as PAN. Sharma et al . reported 4 cases (14.8% of the cohort) with dilated cardiomyopathy as cardiac involvement in PAN.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of early myocardial dysfunction with strain echocardiography in chronic hepatitis B patients

et al. 2019

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Introduction It is well known that chronic hepatitis B virus infection (CHBV) can be associated with cirrhosis and hepatocellular carcinoma but it can also be associated with extra‐hepatic effects, of which cardiac manifestations are the one of the least known. There is a limited amount of data about myocardial dysfunction in CHBV and insufficient data of strain echocardiography in CHBV. The aim of this study was to detect early myocardial dysfunction in CHBV using strain echocardiography. Method This prospective study included 40 CHBV patients without anti‐viral treatment, 40 CHBV patients under anti‐viral treatment, and 40 healthy volunteers as control group from 2017 October to 2018 May. The patients in all groups were aged 30–60 years, with no co‐morbid diseases. Any patients with pathologies that would cause myocardial dysfunction were excluded from the study. All patients were evaluated with transthoracic two‐dimensional (2D), tissue Doppler, and strain echocardiography. Results The mean age and gender distribution were similar in all groups (P = 0.677). A statistically significant difference was determined between the groups in respect of the global circumferential strain and global longitudinal strain values (P < 0.01). The difference in the mean lateral s′ was of statistical significance between the CHBV patients and the control group (P = 0.035). No statistically significant difference was determined in respect of the other echocardiographic parameters. Conclusion As it is a chronic necro‐inflammatory period, chronic HBV can affect myocardial functions. Traditional echocardiographic parameters may not be useful in the detection of early myocardial dysfunction. The results of this study showed that strain echocardiography may be more valuable in early myocardial dysfunction rather than routine 2D echocardiography in CHBV patients.

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“…Small vessels vasculitis includes two distinct categories based on pathogenesis: antineutrophil cytoplasm antibody (ANCA)‐associated vasculitis and immune complex‐associated vasculitis. ANCA‐associated vasculitis include granulomatosis with polyangiitis (GPA; previously known as Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA; Churg‐Strauss syndrome) . Immune‐complex small‐vessel vasculitis include immunoglobulin A (IgA) vasculitis (Henoch‐Schonlein purpura), cryoglobulinemic vasculitis and hypocomplementemic urticarial vasculitis (anti‐C1q vasculitis).…”

Section: Introductionmentioning

confidence: 99%

Imaging in small and medium vessel vasculitis

2019

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Vasculitis includes a group of disorders characterized by inflammation of the vessel wall and classified based on the diameter of the predominantly involved vessels. Granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis and Henoch-Schonlein purpura are the important entities in the small vessel vasculitis group, while polyarteritis nodosa and Kawasaki disease represent the medium vessel vasculitis group. The clinical manifestations may be non-specific and there may be considerable overlap with the other disorders. Imaging plays an important role in diagnosis as well as the management of patients with small and medium vessel vasculitis.Imaging allows direct evaluation of the arteries in medium vessel vasculitis. However, the involved vessels in small vessel vasculitis are smaller than the resolution of the current imaging techniques. Hence, only the end organ changes secondary to involvement of small vessels are examined. In this review we discuss the role of current imaging modalities (predominantly computed tomography and magnetic resonance imaging) as well as individual disease entities in the groups of small and medium vessel vasculitis.

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Polyarteritis nodosa in north India: clinical manifestations and outcomes

Abstract: In comparison to classic PAN in other populations, classic PAN in north India is associated with higher neurological involvement and lower GI involvement.

Cited by 17 publications

References 21 publications

Comparing polyarteritis nodosa in children and adults: a single center study

Comparing polyarteritis nodosa in children and adults: a single center study

Evaluation of early myocardial dysfunction with strain echocardiography in chronic hepatitis B patients

Imaging in small and medium vessel vasculitis

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