Polyarthritis as the presenting symptom of the occurrence and recurrence of a laryngeal carcinoma.

Eggelmeijer, F.; Macfarlane, J. D.

doi:10.1136/ard.51.4.556

Cited by 20 publications

(20 citation statements)

References 11 publications

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“…The age of onset generally reflects that of the associated malignancy. In our review including this case, patients ranged from 43-76 with a median of 61 years [3][4][5][7][8][9][10][11] . There does not appear to be a gender predilection.…”

Section: Discussionmentioning

confidence: 99%

“…Our goal is to review the differential diagnosis of inflammatory polyarthritis before specifically discussing the diagnosis, pathophysiology, and treatment of CP. Carcinomatous polyarthritis has been reported with a variety of solid tumors including lung, gastric, colon, breast, ovarian, laryngeal, and pancreatic (Table 1) 3-5, [7][8][9][10][11] . The exact prevalence is unknown, but it is thought to be rare 4,12 .…”

Section: Discussionmentioning

confidence: 99%

“…There does not appear to be a gender predilection. It has been reported to precede the diagnosis of cancer anywhere from 1 to 20 months, with most malignancies manifesting themselves within 3 months of joint symptoms [3][4][5][7][8][9][10][11] . CP is a diagnosis of exclusion.…”

Section: Discussionmentioning

confidence: 99%

“…Peak onset of RA has been reported to be between 30-55 years of age; however, the incidence increases with increasing age, making the distinction between RA and CP particularly difficult in older populations. The arthritis in both conditions generally presents over the course of weeks to months [3][4][5]6,[8][9][10][11] . In both conditions, patients commonly present with soft tissue swelling, limited range of motion of affected joints, and morning stiffness [3][4][5][6][8][9][10][11] .…”

Section: Discussionmentioning

confidence: 99%

“…The arthritis in both conditions generally presents over the course of weeks to months [3][4][5]6,[8][9][10][11] . In both conditions, patients commonly present with soft tissue swelling, limited range of motion of affected joints, and morning stiffness [3][4][5][6][8][9][10][11] . Features consistent with chronic disease and inflammation, including anemia, an elevated erythrocyte sedimentation rate and c-reactive protein, are often observed [3][4][5][6][7]11 .…”

Section: Discussionmentioning

confidence: 99%

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Migratory Polyarthritis as a Paraneoplastic Syndrome

et al. 2008

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Carcinomatous polyarthritis (CP) is a rare paraneoplastic disorder that has been associated with a variety of solid tumors. It presents in a similar manner to other polyarticular disorders and often precedes detection of the underlying malignancy, making recognition critical. CP responds to the treatment of the neoplastic process. We present a patient who initially presented with asymmetric inflammatory polyarthritis who was later diagnosed with bronchogenic carcinoma. Following the case report we present our learning objectives, which include the differential diagnosis of inflammatory polyarthritis, diagnostic approach to CP, and features that distinguish it from other more common causes of polyarthritis. We conclude with a brief discussion of the pathophysiology and management of CP.KEY WORDS: carcinomatous polyarthritis; migratory arthritis; paraneoplastic syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Migratory Polyarthritis as a Paraneoplastic Syndrome

et al. 2008

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An unusual case of carcinoma polyarthritis with associated vasculitis

Madiedo

Murthy

Cortese

et al. 1997

Arthritis & Rheumatism

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This report describes a patient who presented with an unusual polyarthritis syndrome. After extensive evaluation, squamous cell carcinoma of the lung was diagnosed. During the course of the illness, the patient developed vasculitic features and "rheumatoid-like" nodules. Two months after the administration of combined-modality therapy for stage IIIA non-small cell lung carcinoma, the signs and symptoms of polyarthritis and vasculitis had disappeared completely. Ten months later, the patient remains in clinical remission. This is the first published report of simultaneous vasculitic and polyarticular manifestations in a patient with carcinoma polyarthritis.Nonhematologic malignancies may involve joints either by direct invasion or by a paraneoplastic effect. Breast and lung primary cancers are the most frequent to metastasize to articular structures, often to the knees (1). Polyarticular metastases infrequently predate discovery of the cancer; severe destruction on radiographs may be a clue (2). Paraneoplastic arthropathies are among the musculoskeletal manifestations of cancer. Rarely, polyarthritis is the presenting sign of malignancy. Although the mechanism is unclear, the polyarthritis often improves with treatment of the underlying malignancy. Distinguishing features of "carcinoma polyarthritis" include sudden onset at an older age, asymmetry, and predominant involvement of the legs and sparing of wrists and small joints. Usually absent are rheumatoid nodules, rheumatoid factor, and a family history of rheumatic disease. Herein we report the case of a woman with an unusual polyarthritis syndrome with associated vasculitis. This case depicts carcinoma poly- Submitted for publication July 9, 1996; accepted in revised form November 19, 1996. arthritis with an unusual pattern of joint involvement and systemic manifestations, illustrating the difficulties in diagnosis with this presentation of carcinoma. Carcinoma should be considered early in the differential diagnosis of atypical polyarthritis syndromes. CASE REPORTThe patient was in excellent health until August 1994 when, at the age of 59, she reported the abrupt onset of arthritis and arthralgias involving the neck, hands, wrists, knees, hips, and ankles. She consulted her local physician, and was started on a regimen of methylprednisolone 32 mg/day on a tapering schedule. Initial resolution of symptoms was achieved. However, during the following 2 months, symptoms recurred every time the methylprednisolone dosage was decreased. During the relapses, she also reported episodes of jaw claudication and developed infarction of her left third finger. She consulted several physicians, and in December 1994 a presumptive diagnosis of a generalized connective tissue disorder was made. Methylprednisolone was discontinued and hydroxychloroquine was started. Minimal symptomatic response was achieved, and the drug was subsequently discontinued due to lack of tolerability.Similar episodes recurred until March 1995. At that time she presented to our hospital with a 2-da...

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Carcinomatous Polyarthritis

Raja

2022

Rare Diseases of the Immune System

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Polyarthritis as the presenting symptom of the occurrence and recurrence of a laryngeal carcinoma.

Cited by 20 publications

References 11 publications

Migratory Polyarthritis as a Paraneoplastic Syndrome

Migratory Polyarthritis as a Paraneoplastic Syndrome

An unusual case of carcinoma polyarthritis with associated vasculitis

Carcinomatous Polyarthritis

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