Polyarthritis Caused by Acinetobacter kookii in a Rothschild's Giraffe Calf (Giraffa camelopardalis rothschildi)

Schwarz, Štefan; Mensing, N.; Hörmann, F.; Schneider, Marianne; Baumgärtner, Wolfgang

doi:10.1016/j.jcpa.2020.06.015

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…From a veterinary perspective, Acinetobacter spp. are also frequently isolated from companion [ 16 , 17 , 18 ], zoo [ 19 ], wildlife animals [ 20 , 21 ] and livestock [ 22 , 23 , 24 , 25 , 26 ], and their role as nosocomial MRGNs has also been evaluated as critically important in animal clinics and patients suffering from, e.g., skin, wound, and systemic infections [ 27 ]. Direct zoonotic transmission chains seem to be rare, but companion animals represent a potential source for spillover in this regard [ 16 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Imported Pet Reptiles and Their “Blind Passengers”—In-Depth Characterization of 80 Acinetobacter Species Isolates

Unger

Eisenberg²,

Prenger‐Berninghoff

et al. 2022

Microorganisms

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Reptiles are popular pet animals and important food sources, but the trade of this vertebrate class is—besides welfare and conservation—under debate due to zoonotic microbiota. Ninety-two shipments of live reptiles were sampled during border inspections at Europe’s most relevant transshipment point for the live animal trade. Acinetobacter spp. represented one significant fraction of potentially MDR bacteria that were further analyzed following non-selective isolation or selective enrichment from feces, urinate, or skin samples. Taxonomic positions of respective isolates were confirmed by MALDI-TOF MS and whole-genome sequencing analysis (GBDP, dDDH, ANIb, and rMLST). The majority of the 80 isolates represented established species; however, a proportion of potentially novel taxa was found. Antimicrobial properties and genome-resistance gene screening revealed novel and existing resistance mechanisms. Acinetobacter spp. strains were most often resistant to 6–10 substance groups (n = 63) in vitro. Resistance to fluorchinolones (n = 4) and colistin (n = 7), but not to carbapenems, was noted, and novel oxacillinase variants (n = 39) were detected among other genes. Phylogenetic analysis (MLST) assigned few isolates to the known STs (25, 46, 49, 220, and 249) and to a number of novel STs. No correlation was found to indicate that MDR Acinetobacter spp. in reptiles were associated with harvesting mode, e.g., captive-bred, wild-caught, or farmed in natural ecosystems. The community of Acinetobacter spp. in healthy reptiles turned out to be highly variable, with many isolates displaying a MDR phenotype or genotype.

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Section: Introductionmentioning

confidence: 99%

Imported Pet Reptiles and Their “Blind Passengers”—In-Depth Characterization of 80 Acinetobacter Species Isolates

Unger

Eisenberg²,

Prenger‐Berninghoff

et al. 2022

Microorganisms

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The multifaceted genusAcinetobacter: from infection to bioremediation

Dahal,

Paul,

Gupta

2023

Journal of Applied Microbiology

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Acinetobacter is a vast bacterial genus comprising of numerous species with variable characteristics. The enigma associated with clinical strains which have been implicated in many nosocomial outbreaks has prompted the need for continuous research on pathogens like Acinetobacter baumannii and members of the ACB complex. However, numerous species of Acinetobacter genus possess diverse metabolic capabilities and have the potential for a plethora of industrial and environment-based applications. Therefore, a comprehensive review on the entire genus including many under-represented topics would contribute extensive information to the scientific community indulged in Acinetobacter research. The current review is a unique compilation which attempts to provide the latest update on the genus covering its clinical as well as ecological aspects. Moreover, it is the first study of its kind which focuses on the entire genus and elaborates on the phylogenetic relationships, pathogenesis and virulence mechanisms followed by emerging biotechnological applications with future directions.

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Third-generation cephalosporin resistant Escherichia coli in dogs and cats in Germany in 2019–2021

Frenzer,

Feuer,

Bartel

et al. 2024

PLoS ONE

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Objectives Antimicrobial resistance (AMR) poses a worldwide challenge, threatening global health. The objective of this research was to determine the 3rd generation cephalosporin resistance (3GCR) proportion in Escherichia (E.) coli isolated from clinical samples of dogs and cats in Germany. Methods The study utilized result data from antimicrobial susceptibility testing (AST) of isolates obtained from diagnostic samples collected from dogs and cats send in for bacterial examination. Data includes AST results from 3,491 veterinary practices in Germany spanning the years 2019 to 2021, representing 33.1% of practices and clinics nationwide. Out of 175,171 clinical samples, a total of 25,491 E. coli strains (14,6%) were evaluated for their susceptibility to antimicrobials, in particular the 3rd generation cephalosporin cefovecin, but also aminoglycosides (gentamicin, GEN), fluoroquinolones (enrofloxacin, ENR), tetracyclines (doxycycline), phenicols (chloramphenicol), folate pathway inhibitors (sulfamethoxazole + trimethoprim), and nitrofurans (nitrofurantoin). Results The cefovecin resistance proportion was 11.6% in the study period. Geographical analysis showed local variations in 3GCR in E. coli of ±3%. Regarding all E. coli isolates investigated, resistance proportions were observed as follows: 12% for sulfamethoxazole-trimethoprim, 7% for enrofloxacin, 8% for chloramphenicol and 4% for gentamicin. Notably, 3GCR E. coli showed significantly higher resistance proportions, specifically 30% for sulfamethoxazole-trimethoprim, 28% for chloramphenicol, 18% for enrofloxacin and 14% for gentamicin. Conclusions This study represents the first of its kind to utilize an extensive dataset encompassing dogs and cats across Germany. Companion animals have close contact to their owners and transmission of 3GCR between them is likely as well as acquisition from other environmental sources. Resistance proportions (6.7%) against the antibiotic ceftazidime as reported by the German AMR surveillance for human medicine were lower than in our veterinary data. Our study provides an overview of the current 3GCR resistance proportion in Germany and demonstrates the importance of integrated AMR monitoring.

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Polyarthritis Caused by Acinetobacter kookii in a Rothschild's Giraffe Calf (Giraffa camelopardalis rothschildi)

Cited by 5 publications

References 37 publications

Imported Pet Reptiles and Their “Blind Passengers”—In-Depth Characterization of 80 Acinetobacter Species Isolates

Imported Pet Reptiles and Their “Blind Passengers”—In-Depth Characterization of 80 Acinetobacter Species Isolates

The multifaceted genusAcinetobacter: from infection to bioremediation

Third-generation cephalosporin resistant Escherichia coli in dogs and cats in Germany in 2019–2021

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