Polybrominated diphenyl ethers in the environment and human external and internal exposure in China: A review

Jiang, Yu; Yuan, Longmiao; Lin, Qinhao; Ma, Shentao; Yu, Yingxin

doi:10.1016/j.scitotenv.2019.133902

Cited by 109 publications

(28 citation statements)

References 264 publications

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“…Furthermore, it has been demonstrated that PBDEs can enter the human body via inhalation, dermal contact, and ingestion, the latter being relevant in toddlers and children as they may spend much of their time on carpets, making them highly vulnerable to these contaminants (4). In addition, studies have demonstrated that PBDEs can bio-accumulate in human blood, breast milk, placenta, and fat tissues, as well as in animal tissues (7)(8)(9)(10) entering the food chain (EFSA Panel, 2011).…”

Section: Introductionmentioning

confidence: 99%

2,2’4,4’-Tetrabromodiphenyl Ether (PBDE-47) Modulates the Intracellular miRNA Profile, sEV Biogenesis and Their miRNA Cargo Exacerbating the LPS-Induced Pro-Inflammatory Response in THP-1 Macrophages

Longo

Adamo

et al. 2021

Front. Immunol.

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The 2,2’4,4’-tetrabromodiphenyl ether (PBDE-47) is one of the most prominent PBDE congeners detected in the environment and in animal and human tissues. Animal model experiments suggested the occurrence of PBDE-induced immunotoxicity leading to different outcomes and recently we demonstrated that this substance can impair macrophage and basophil activities. In this manuscript, we decided to further examine the effects induced by PBDE-47 treatment on innate immune response by looking at the intracellular expression profile of miRNAs as well as the biogenesis, cargo content and activity of human M(LPS) macrophage cell-derived small extracellular vesicles (sEVs). Microarray and in silico analysis demonstrated that PBDE-47 can induce some epigenetic effects in M(LPS) THP-1 cells modulating the expression of a set of intracellular miRNAs involved in biological pathways regulating the expression of estrogen-mediated signaling and immune responses with particular reference to M1/M2 differentiation. In addition to the cell-intrinsic modulation of intracellular miRNAs, we demonstrated that PBDE-47 could also interfere with the biogenesis of sEVs increasing their number and selecting a de novo population of sEVs. Moreover, PBDE-47 induced the overload of specific immune related miRNAs in PBDE-47 derived sEVs. Finally, culture experiments with naïve M(LPS) macrophages demonstrated that purified PBDE-47 derived sEVs can modulate macrophage immune response exacerbating the LPS-induced pro-inflammatory response inducing the overexpression of the IL-6 and the MMP9 genes. Data from this study demonstrated that PBDE-47 can perturb the innate immune response at different levels modulating the intracellular expression of miRNAs but also interfering with the biogenesis, cargo content and functional activity of M(LPS) macrophage cell-derived sEVs.

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Section: Introductionmentioning

confidence: 99%

2,2’4,4’-Tetrabromodiphenyl Ether (PBDE-47) Modulates the Intracellular miRNA Profile, sEV Biogenesis and Their miRNA Cargo Exacerbating the LPS-Induced Pro-Inflammatory Response in THP-1 Macrophages

Longo

Adamo

et al. 2021

Front. Immunol.

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“…As a class of brominated ame retardants (BFRs), polybrominated diphenyl ethers (PBDEs) have been widely used in plastics, textiles, electronic circuits, building materials, household electric appliances, and other elds (Jiang et al, 2019). During the production, uses and disposal, PBDEs are released and accumulated in the environment easily because they are additives mixed into polymers and are not chemically bound to the plastic or textiles (Darnerud et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In recent decades, PBDEs are reported to be a group of global environmental pollutants, which have been detected in various environmental matrices and human tissues (Li et al, 2016). Numerous studies have demonstrated that (1) PBDEs are one of the persistent organic pollutants (POPs) due to their lipophilic, persistent, and bio-accumulative characteristics (Wang et al, 2011); (2) PBDEs exhibit potential toxicity to sh, mammals, and even human beings, such as liver toxicity, reproductive toxicity, neurotoxicity, and others (Jiang et al, 2019);(3) the target organs of PBDEs are mainly adipose tissue nervous system thyroid and reproductive development system (Dingemans et al, 2011); and (4) low-brominated PBDEs are generally more toxic than high-brominated ones (Dingemans et al, 2011). Because of their toxicity to humans and ecosystems, the production and uses of PBDEs have been banned or phased out by the most major global entities since 2004 (Zhou et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…As a "sink" for almost all types of pollutants, marine environment is the ultimate gathering place of PBDEs, which have been detected in seawater, sediments, and marine organisms (Jiang et al, 2019). And it was reported that PBDEs were several orders of magnitude higher in organisms than that in water because of their lipophilicity (Lee and Kim, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Dong

Gao

Qian

et al. 2021

Preprint

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In this work, Phaeodactylum tricornutum was used to investigate the toxicity of 4,4'-dibromodiphenyl ether (BDE-15). Results showed that BDE-15 inhibited the photosynthetic activity and growth of P. tricornutum significantly with 24, 48, 72, and 96 h EC50 values of 1.03, 0.44, 0.41, and 0.42 mg L-1, respectively, indicating that it was a highly toxic substance. Moreover, BDE-15 could cause cell deformation, and a series of physiological, biochemical, and molecular changes in the cells. Under the exposure of BDE-15, contents of chlorophyll a and soluble protein decreased significantly, but reactive oxygen species (ROS) were accumulated in the algal cells, which may cause or intensify the peroxidation of membrane lipids. For alleviating the toxicity of excessive ROS, activities of antioxidant enzymes increased dramatically when this diatom was exposed to BDE-15. Thus, it is concluded that the overproduction of ROS may be regarded as one of the major factors in BDE-15 toxicity.

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“…Polybrominated diphenyl ethers (PBDEs) are widely used flame retardant chemicals in daily necessities such as textiles, electronic circuit board, and plastics in the past decades (Wei et al, 2018; Yang et al, 2018). The United Nations Environment Programme (UNEP) has listed tetra ‐, penta ‐, hexa ‐, hepta ‐, octa ‐, and deca ‐PBDEs in the Stockholm Convention as persistent organic pollutants (POPS) to restrict their production and consumption (Jiang et al, 2019). As analogs and metabolites of PBDEs, hydroxylated PBDEs (OH‐PBDEs, Fig.…”

Section: Introductionmentioning

confidence: 99%

Emerging environmental pollutants hydroxylated polybrominated diphenyl ethers: From analytical methods to toxicology research

Wei

Cai

2020

Mass Spectrometry Reviews

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Hydroxylated polybrominated diphenyl ethers (OH‐PBDEs) are of particular concern due to their ubiquitous distribution and adverse health effects. Significant progress has been made in the characterization of OH‐PBDEs by using mass spectrometry (MS). In this review, we summarize applications of MS‐based techniques in detection, environmental and biota distribution, and potential health risk effects, hoping to unfold an overall picture on account of current knowledge of OH‐PBDEs. The analytical methodologies are discussed from sample pretreatment to MS analysis. The methods including gas chromatography‐MS (GC‐MS), liquid chromatography‐MS (LC‐MS), and ion mobility spectrometry‐MS (IMS‐MS) are discussed. GC‐MS is the most frequently adopted method in the analysis of OH‐PBDEs due to its excellent chromatographic resolution, high sensitivity, and strong ability for unknown identification. LC‐MS has been widely used for its high sensitivity and capability of direct analysis. As a newly developed technique, IMS‐MS provides high specificity, which greatly facilitates the identification of isomers. OH‐PBDEs pervasively existed in both abiotic and biotic samples, including humans, animals, and environmental matrices. Multiple adverse health effects have been reported, such as thyroid hormone disruption, estrogen effects, and neurotoxicity. The reported potential pathological mechanisms are also reviewed. Additionally, MS‐based metabolomics, lipidomics, and proteomics have been shown as promising tools to unveil the molecular mechanisms of the toxicity of OH‐PBDEs. © 2020 John Wiley & Sons Ltd. Mass Spec Rev

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Polybrominated diphenyl ethers in the environment and human external and internal exposure in China: A review

Cited by 109 publications

References 264 publications

2,2’4,4’-Tetrabromodiphenyl Ether (PBDE-47) Modulates the Intracellular miRNA Profile, sEV Biogenesis and Their miRNA Cargo Exacerbating the LPS-Induced Pro-Inflammatory Response in THP-1 Macrophages

2,2’4,4’-Tetrabromodiphenyl Ether (PBDE-47) Modulates the Intracellular miRNA Profile, sEV Biogenesis and Their miRNA Cargo Exacerbating the LPS-Induced Pro-Inflammatory Response in THP-1 Macrophages

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Emerging environmental pollutants hydroxylated polybrominated diphenyl ethers: From analytical methods to toxicology research

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