Polybutylene Succinate Processing and Evaluation as a Micro Fibrous Graft for Tissue Engineering Applications

Miceli, Giovanni Carlo; Palumbo, Fabio Salvatore; Bonomo, Francesco Paolo; Zingales, Massimiliano; Licciardi, Mariano

doi:10.3390/polym14214486

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…The optimized scaffold morphology featured a small diameter and micro-porous conduit, facilitating cell integration, adhesion, and growth while preventing cell infiltration through the graft’s wall. Mechanical properties of the tubular conduits fell within the physiological range as well [ 17 ]. Additionally, Vigni et al demonstrated in another study that a PBS microfibrillar scaffold used in critical bone defects on a rabbit model could potentially enhance bone regeneration [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures

et al. 2023

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The utilization of a planar poly(1,4-butylene succinate) (PBS) scaffold has been demonstrated as an effective approach for preserving nerve continuity and facilitating nerve regeneration. In this study, we assessed the characteristics of a microfibrous tubular scaffold specifically designed and fabricated through electrospinning, utilizing PBS as a biocompatible and biodegradable material. These scaffolds were evaluated as nerve guide conduits in a rat model of sciatic nerve neurotmesis, demonstrating both their biodegradability and efficacy in enhancing the reconstruction process over a long-term period (1-year follow-up). Histological assay and electrophysiological evaluation were performed to compare the long-term outcomes following sutureless repair with the microfibrillar wrap to outcomes obtained using traditional suture repair.

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Section: Introductionmentioning

confidence: 99%

Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures

et al. 2023

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“…Polybutylene succinate (PBS) scaffold has proven to be an excellent biomaterial in various fields, including osteogenesis [ 10 ], with high biocompatibility and easy processability by electrospinning technique [ 11 , 12 ]. It is a commercially available, biodegradable, thermoplastic aliphatic polyester synthesized by the polycondensation of succinic acid and butanediol.…”

Section: Introductionmentioning

confidence: 99%

Improved Bone Regeneration Using Biodegradable Polybutylene Succinate Artificial Scaffold in a Rabbit Model

Vigni

Cassata

Caldarella

et al. 2022

JFB

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The treatment of extensive bone loss represents a great challenge for orthopaedic and reconstructive surgery. Most of the time, those treatments consist of multiple-stage surgeries over a prolonged period, pose significant infectious risks and carry the possibility of rejection. In this study, we investigated if the use of a polybutylene succinate (PBS) micro-fibrillar scaffold may improve bone regeneration in these procedures. In an in vivo rabbit model, the healing of two calvarial bone defects was studied. One defect was left to heal spontaneously while the other was treated with a PBS scaffold. Computed tomography (CT) scans, histological and immunohistochemical analyses were performed at 4, 12 and 24 weeks. CT examination showed a significantly larger area of mineralised tissue in the treated defect. Histological examination confirmed a greater presence of active osteoblasts and mineralised tissue in the scaffold-treated defect, with no evidence of inflammatory infiltrates around it. Immunohistochemical analysis was positive for CD56 at the transition point between healthy bone and the fracture zone. This study demonstrates that the use of a PBS microfibrillar scaffold in critical bone defects on a rabbit model is a potentially effective technique to improve bone regeneration.

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“…Polymeric nanofibrillar scaffolds, due to their suitable physicochemical and morphological properties, represent excellent platforms for tissue engineering and biomedical applications [ 24 , 25 , 26 ]. The microstructure of such systems is comparable to the tissues extracellular matrix (ECM) and it is crucial for adhesion, growth, and cell proliferation [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

Pitarresi

Barberi

Palumbo

et al. 2022

IJMS

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The development of biomedical systems with antimicrobial and antibiofilm properties is a difficult medical task for preventing bacterial adhesion and growth on implanted devices. In this work, a fibrillar scaffold was produced by electrospinning a polymeric organic dispersion of polylactic acid (PLA) and poly(α,β-(N-(3,4-dihydroxyphenethyl)-L-aspartamide-co-α,β-N-(2-hydroxyethyl)-L-aspartamide) (PDAEA). The pendant catechol groups of PDAEA were used to reduce silver ions in situ and produce silver nanoparticles onto the surface of the electrospun fibers through a simple and reproducible procedure. The morphological and physicochemical characterization of the obtained scaffolds were studied and compared with virgin PLA electrospun sample. Antibiofilm properties against Pseudomonas aeruginosa, used as a biofilm-forming pathogen model, were also studied on planar and tubular scaffolds. These last were fabricated as a proof of concept to demonstrate the possibility to obtain antimicrobial devices with different shape and dimension potentially useful for different biomedical applications. The results suggest a promising approach for the development of antimicrobial and antibiofilm scaffolds.

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Polybutylene Succinate Processing and Evaluation as a Micro Fibrous Graft for Tissue Engineering Applications

Cited by 6 publications

References 33 publications

Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures

Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures

Improved Bone Regeneration Using Biodegradable Polybutylene Succinate Artificial Scaffold in a Rabbit Model

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

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