Polycaprolactone as Drug Carrier for an Antifungal Agent

Abstract

One of the most suitable and most used biodegradable polymers in particulate drug delivery is Polycaprolactone. This could be attributed to its several important characteristics including its low degradation rate, high permeability and low toxicity. In this study, Polycaprolactone microspheres loaded with the antifungal agent Amphotericin B were synthesized by means of the solvent evaporation method. The prepared microspheres had homogeneous particle sizes between 110 and 125 µm. they also showed a porous structure and a spherical profile. Satisfactory drug encapsulation percentages and drug loading values were obtained. They varied from 28 to 61 % and 0.22 to 1.13 % respectively. These observed results could be related to the properties of both drug and polymer such as hydrophobicity and solubility in organic solvents. In addition, the low degradation activity of the polymer Polycaprolactone had a direct impact on the release rate of Amphotericin B, yielding prolonged and slow release profiles for most of the formulations. Finally, Infrared study revealed that the method used for encapsulation of Amphotericin B with Polycaprolactone did not have any negative effect on the integrity and stability of the drug.

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

“…Owing to its high permeability for small drug molecules [10], the aliphatic polyester, PCL represents an important candidate for fabricating carriers for drug delivery applications, including: microparticles [11], nanoparticles [12], microspheres [13], coatings [14], and scaffolds [15]. However, due to its intrinsic high hydrophobicity and crystallinity, PCL degrades rather slowly.…”

Central composite design optimization for a controlled valsartan release from polycaprolactone microspheres

“…However, the hydrophobic property of PCL causes delay in the penetration of water and therefore the diffusion of the drug through the amorphous region is delayed 67 . Moreover, it has been reported that the PCL is more hydrophobic than other 68 . This feature makes its degradation very slow in aqueous medium, and in return suitable for controlled and sustained drug release.…”

“…67 Moreover, it has been reported that the PCL is more hydrophobic than other. 68 This feature makes its degradation very slow in aqueous medium, and in return suitable for controlled and sustained drug release.…”

Tetracycline Adsorption onto Agave Americana Activated Carbon: Studies of Physicochemical Parameters and Porous Structure

“…Carbon nanomaterials, such as the activated carbons, can meet the standard criteria for good adsorption because they have a high surface area, a big pore volume, and are characterized by strong physicochemical interactions with the pollutants [5]. Modeling of the adsorption process was previously performed in order to find a clear relation between the experimental adsorption isotherm and the theoretical model, as well as with the values of the energy of adsorbate interaction with the surface [6,7]. For description of the adsorption mechanism by an individual model expression, we usually used the most known models such as Langmuir, Freundlich, and Langmuir-Freundlich models [8].…”