Polycaprolactone/calcium sulfate whisker/barium titanate piezoelectric ternary composites for tissue reconstruction

Liu, Jinyan; Hu, Xiaoyue; Humin, Dai; San, Zhi; Wang, Fuke; Ren, Li; Li, Guoyuan

doi:10.1177/2633366x19897923

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Research by Liu et al [ 61 ] has shown that piezoelectric composites have great compatibility with bone cells that successfully increase cell viability by culturing cells on the composite matrix. The findings have displayed the potential application of piezoelectric materials that are appropriate for other types of body tissue engineering as well.…”

Section: Protein-based Smart Materials In Tissue Engineeringmentioning

confidence: 99%

Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels

Ganeson,

Tan Xue May,

Abdullah

et al. 2023

Pharmaceutics

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Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external stimuli. However, protein-based smart materials allow modular protein domains with different functionalities and responsive behaviours to be easily combined. Wherein, these “smart” behaviours can be tuned by amino acid identity and sequence. This review aims to give an insight into the design of smart materials, mainly protein-based piezoelectric materials, shape-memory materials, and hydrogels, as well as highlight the current progress and challenges of protein-based smart materials in tissue engineering. These materials have demonstrated outstanding regeneration of neural, skin, cartilage, bone, and cardiac tissues with great stimuli-responsive properties, biocompatibility, biodegradability, and biofunctionality.

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Section: Protein-based Smart Materials In Tissue Engineeringmentioning

confidence: 99%

Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels

Ganeson,

Tan Xue May,

Abdullah

et al. 2023

Pharmaceutics

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“…Therefore, different materials (such as ceramic materials) are considered to progress PCL osteoconductivity and bioactivity. 22,23 Biodegradable polymers and bioactive ceramics combine to form a novel composite material with potential uses in tissue engineering, such as short-term bone implants, dental fillers, and biocompatible scaffolds. Polymers’ advantages, such as flexibility and deformability under stress, are preserved while the composite material’s strength and bioactivity are improved.…”

Section: Introductionmentioning

confidence: 99%

Electrospun nano-barium titanate/polycaprolactone composite coatings on titanium and Ti13Nb13Zr alloy

Ibrahim,

Hamad

2023

Composites and Advanced Materials

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Using coated implant materials has been demonstrated to enhance bone regeneration and expedite healing around implant sites significantly. Generally, employing a polymeric matrix reinforced with ceramic materials has been considered a promising composite material for the coating of implants. The present study aimed to evaluate the effect of mixing varying concentrations of nano-barium titanate (nanoBaTiO3) (9, 18, and 36 wt%) to polycaprolactone (PCL) (18 wt%) on the properties of coatings applied to commercially pure titanium (CpTi) and Ti13Nb13Zr alloys implant materials. The electrospinning technique was utilised to fabricate the coatings, and the samples were characterised using atomic force microscopy (AFM) to investigate the composite coating’s surface roughness and topography; the incorporation of a high amount of BaTiO3 resulted in increased roughness of the coating layer on CpTi and Ti13Nb13Zr alloys (69.78 nm and 96.88 nm, respectively). Field emission scanning electron microscopy (FE-SEM) was used to investigate the surface morphology; the fibre diameters of BT/PCL composite were 80 to 534 nm for different mixture concentrations. Fourier transform infrared spectroscopy (FTIR) verified the chemical bonds in the composite coating. Results indicated that increasing the proportion of nano-barium titanate in the coating composition reduced water contact angles and enhanced the adhesion strength of the composite coating to the substrate. These findings provide valuable information for developing new coating materials to promote the growth of new bone and accelerate healing around implants.

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“…Polycaprolactone (PCL) is an organic component because of its adaptability and biodegradability has been considered much in tissue engineering applications [25].…”

Section: Introductionmentioning

confidence: 99%

Study on Polycaprolactone Coated Hierarchical Meso/ Macroporous Titania Scaffolds for Bone Tissue Engineering

Nemati

Mirhadi

2022

IJE

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In this study, the effect of polycaprolactone (PCL) coating on the mechanical strength, cell behavior and cell attachment of the hierarchical meso/macroporous Titania scaffold were investigated. Titania scaffold as the substrate was fabricated through the evaporation-induced self-assembly coupled with the foamy method. Then prepared scaffolds were coated by polycaprolactone solution with three different weight percentages by the dip-coating method. SAXS, WAXRD, SEM, compressive strength, MTT and cell attachment test were applied to characterized the samples. Based on XRD results, as polycaprolactone concentration increased, the intensity of the crystalline polycaprolactone phase increased while the TiO2 peak intensity decreased due to the covering of mesoporous titania by polycaprolactone. Compressive strength showed that by increasing polycaprolactone percent, the porosity decrease from 89.5 to 73.8 % which caused increasing strength from 0.2 to 0.79 MPa. The SEM results illustrated that by increasing polycaprolactone concentration from 1.2 to 1.5 wt%, the macrospores were filled by polycaprolactone. In this regard, The sample containing 1wt% polycaprolactone was choosen as the selective sample. Also, the MTT test reported a small trace of cytotoxicity in contact with the L929 mouse fibroblast cells. The cell attachment test that was performed by using MG63 cells, showed that the coated samples provided the suitable substrate for cells to attach and also showed cell viability on the surface of the coated substrate. Overall, according to the results, the hierarchical meso/macroporous Titania scaffold coated with 1 wt% polycaprolactone, could have good potential to be used in tissue engineering.

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Polycaprolactone/calcium sulfate whisker/barium titanate piezoelectric ternary composites for tissue reconstruction

Cited by 6 publications

References 18 publications

Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels

Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels

Electrospun nano-barium titanate/polycaprolactone composite coatings on titanium and Ti13Nb13Zr alloy

Study on Polycaprolactone Coated Hierarchical Meso/ Macroporous Titania Scaffolds for Bone Tissue Engineering

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