Polycaprolactone thin-film drug delivery systems: Empirical and predictive models for device design

Abstract

Purpose To define empirical models and parameters based on theoretical equations to describe drug release profiles from two polycaprolactone thin-film drug delivery systems. Additionally, to develop a predictive model for empirical parameters based on drugs’ physicochemical properties. Methods Release profiles from a selection of drugs representing the standard pharmaceutical space in both polycaprolactone matrix and reservoir systems were determined experimentally. The proposed models were used to calculate empirical parameters describing drug diffusion and release. Observed correlations between empirical parameters and drug properties were used to develop equations to predict parameters based on drug properties. Predictive and empirical models were evaluated in the design of three prototype devices: a levonorgestrel matrix system for on-demand locally administered contraception, a timolol-maleate reservoir system for glaucoma treatment, and a primaquine-bisphosphate reservoir system for malaria prophylaxis. Results Proposed empirical equations accurately fit experimental data. Experimentally derived empirical parameters show significant correlations with logP, molecular weight, and solubility. Empirical models based on predicted parameters accurately predict experimental release data for three prototype systems, demonstrating the accuracy and utility of these models. Conclusion The proposed empirical models can be used to design polycaprolactone thin-film devices for target geometries and release rates. Empirical parameters can be predicted based on drug properties. Together, these models provide tools for preliminary evaluation and design of controlled-release delivery systems.

Gamma irradiation effects on polycaprolactone/zinc oxide nanocomposite films

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“…As a basic membrane-controlled reservoir system, release rates can be tuned by altering membrane thickness or surface area, and while solid drug remains within the device reservoir providing a constant activity source, the release rate remains constant. [20] [21] [22] Short term, small scale studies are used to develop an appropriate formulation for overcoming dissolution-limited release and to increase the rate of release. Additionally, these studies investigate the relationships between TAF release and device design parameters, providing an understanding of the achievable range of release and the necessary information to design implants with target specifications.…”

Development of random and ordered composite fiber hybrid technologies for controlled release functions

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