Polychlorbiphenyls (Pcb) Induced Fetopathy

Funatsu, Iichiro; Yamashita, Fumio; Ito, Yushi; TSUGAWA, SHIN; Funatsu, Takako; YOSHIKANE, TAKASHI; Hayashi, Masao; Kato, Takeshi; Yakushiji, M; Okamoto, Gen; Yamasaki, Seiichirō; Arima, Tadashi; Kuno, Tsuneko; Ide, Hayami; Ide, I

doi:10.2739/kurumemedj.19.43

Cited by 46 publications

(28 citation statements)

References 2 publications

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“…The first was in 1968 in west Japan, where PCB induced fetopathy was found in babies born to mothers poisoned by contaminated rice oil (Funatsu et al, 1972), although there was no excess of births of girls over boys (Yoshimura et al, 2001). In the second outbreak in Taiwan in 1979, maternal contamination by cooking oil lead to lower birth weight, hyperpigmentation, conjuctivitis, nail changes, natal teeth at birth and consistent developmental delay in the exposed offspring (Rogan et al, 1988), although again in maternal contamination the sex ratio was not affected (Rogan et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Maternal contamination with PCBs and reproductive outcomes in an Australian population

Khanjani

Sim

2006

J Expo Sci Environ Epidemiol

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Polychlorinated biphenyls used previously in industry are widespread environmental contaminants under scrutiny for their possible reproductive effects in humans. In this study, 200 breast milk samples from eligible Victorian mothers were used for measuring maternal contamination and their possible effect on the offspring was investigated. No significant association was found between maternal PCB contamination and low birth weight, small for gestational age and previous miscarriage or stillbirth. The elevated odd ratios of prematurity, increased with increase in contamination level but were nonsignificant. Higher PCB contamination was not in favor of any gender in the offspring. Our results suggest that chronic, low contamination with PCBs does not pose a reproduction threat in humans.

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Section: Discussionmentioning

confidence: 99%

Maternal contamination with PCBs and reproductive outcomes in an Australian population

Khanjani

Sim

2006

J Expo Sci Environ Epidemiol

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“…4). It is (8,10,11). As shown in Table 11, nine of them had unusually grayish, dark-brown stained skin and similar pigmentation of the gingiva and nails was noted in five of them.…”

Section: Analytical Epidemiologic Studiesmentioning

confidence: 97%

Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls

Kuratsune¹,

Yoshimura²,

Matsuzaka³

et al. 1972

Environ Health Perspect

349

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“…A very common feature of the Yusho syndrome is small size at birth (Yoshimura, 1974;Yamashita and Hayashi, 1985;Funatsu et al, 1971;Taki et al, 1969). Children exposed postnatally grew more slowly than unexposed children, though the difference was statistically significant only among males in some studies (Yamaguchi et al, 1971;Fujisawa and Fujiwara, 1972;Yoshimura and Ikeda, 1978).…”

Section: Yushomentioning

confidence: 99%

Effects of pollutants on human prenatal and postnatal growth: Noise, lead, polychlorobiphenyl compounds, and toxic wastes

Schell

1991

Am. J. Phys. Anthropol.

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Industrialization is a major force altering the environment for human habitation. Pollution from industrialization may pose new adaptive challenges for Homo sapiens as well as for other species. The study of human biological adaptation is a traditional area of physical anthropology, but until recently it has not focused on the adaptative challenges of the modern anthropogenic environment. By combining research from anthropology, epidemiology, and public health, it is possible to gauge some of the effects of pollution on human health and adaptation. This review focuses on human growth as a measure of health and a component of human adaptability. Considerable evidence now exists for an adverse impact of lead, noise, and polychlorinated biphenyls on human growth, either prenatal, postnatal, or both. There is substantial replication of results among studies, many of which differ in exposure assessment and classification, sample composition and size, and statistical techniques. Because of this amongstudy variation, specifying the exact amount of growth retardation due to a pollutant is difficult, but the direction and often the magnitude of the effect is similar across studies. There remain numerous barriers to more definitive research on environmental pollutants and health outcomes of importance to biological anthropologists. These are discussed also.Industrial pollution has rapidly and tremendously altered the environment for human habitation. Until industrialization, contaminant levels in the environment and in people were probably quite low. The possible exceptions are few. Lead from poorly fired pottery (Nriagu, 1983) and indoor air pollution from ineffectively drafted hearths (Eisenbud, 1978) may have been the main pollutants a t different times. With the development of craft specialists, occupational exposure began, and from this origin, pollutant levels grew with production. Compared to crafts techniques, industrialization represents a quantum leap in production and in contamination.The environment today contains new materials and old materials at concentrations much higher than people have ever encountered before. Exposure in the home and work place has become routine. A crucial feature of the new exposure pattern is that children are exposed also. The exposure may occur postnatally, or prenatally through passage of contaminants across the placenta. Human physical growth and development is known to be sensitive to a variety of environmental influences. Though early observations on the ecosensitivity of 0 1991 Wiley-Liss, Inc. 158 YEARBOOK OF PHYSICAL ANTHROPOLOGY[Vol. 34, 1991 growth may have been anecdotal, research over the last century has documented specific environmental features associated with variation in the pattern of human growth (Tanner, 1962;Bogin, 1988). The physical influences of temperature, hypoxia, and season of the year, as well as numerous social arrangements and characteristics, including parents' occupations and incomes, birth order, family size, and urban versus rural resid...

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Polychlorbiphenyls (Pcb) Induced Fetopathy

Cited by 46 publications

References 2 publications

Maternal contamination with PCBs and reproductive outcomes in an Australian population

Maternal contamination with PCBs and reproductive outcomes in an Australian population

Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls

Effects of pollutants on human prenatal and postnatal growth: Noise, lead, polychlorobiphenyl compounds, and toxic wastes

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