Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

“…In agreement with most other studies (Caspersen et al 2016;Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005), we found that the PCB and OCP concentrations were higher in older women (Table 4). This association is presumed to be a reflection of the persistency and long human serum half-life of the lipophilic POPs.…”

“…Several studies have reported that the lipophilic POP concentrations are associated with age (Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005), BMI (Fernandez-Rodriguez et al 2015;Halldorsson et al 2008b;Medehouenou et al 2011;Porta et al 2012;Wolff et al 2005), smoking status (Deutch et al 2007(Deutch et al , 2003Fernandez-Rodriguez et al 2015;Wolff et al 2005), and gestational age at blood draw (Adetona et al 2013;Longnecker et al 1999). Hence, in the present study, the temporal trends were analyzed for the lipidcorrected crude data and upon adjustment for these potential confounders.…”

“…We suggest that the lipophilic POPs might be stored in the adipose tissue of women with a high BMI rather than being in circulation. Contrarily, two studies of the adult population in Spain as well as one study of older Medehouenou et al 2011;Porta et al 2012). Long et al (2015) found no statistically significant association between BMI and OCP or PCB levels in 194 Greenlandic pregnant women (Long et al 2015).…”

“…The temporal changes of lipophilic POP concentrations have not been studied much in Europe in recent years, and to our knowledge, no time trend studies have been conducted in Denmark. The lipophilic POP concentrations in human serum may be dependent on factors such as age, body mass index (BMI), parity, and gender (Caspersen et al 2016;Fernandez-Rodriguez et al 2015;Long et al 2015;Medehouenou et al 2011;Porta et al 2012;Rylander et al 2012;Sandau et al 2000;Wolff et al 2005). Hence, it is important to control for these covariates when conducting a time trend study by e.g., selecting a homogenous population such as nulliparous pregnant women.…”

“…were used as heat transfer fluids, hydraulic fluids, solvent extenders, plasticizers, flame retardants, and dielectric fluids until the use was restricted in 1972 and prohibited since the late 1970s in most industrialized countries including Denmark (Medehouenou et al 2011;Noren and Meironyte 2000;Takeuchi et al 2011). As alternatives to PCBs, other compounds such as polybrominated biphenyls (PBBs) and polybrominated diphenyl ethers (PBDEs) were then introduced as flame retardants.…”