Polychlorinated dibenzo-<i>p</i>-dioxin and dibenzofuran concentrations in the serum samples of workers at continuously burning municipal waste incinerators in Japan

Kumagai, Shinji; Koda, Shigeki; Miyakita, Takashi; Yamaguchi, Hideki; Katagi, Kenichi; Yasuda, Nobufumi

doi:10.1136/oem.57.3.204

Cited by 51 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found the content of heptachlorinated dibenzofurans and dibenzodioxins were several orders of magnitude greater than other total congeners (tetra, penta, hexa, octa); however, congener-specific data within the hepta class were not reported. Similar findings have been found in Japanese incinerator workers (Kumagai et al 2000(Kumagai et al , 2002. Our results demonstrating differences for the two hepta congeners were not anticipated but are consistent with other published data and suggest that these analytes may be useful for detecting exposures to burning plastics containing chlorine.…”

Section: Discussionsupporting

confidence: 92%

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Edelman

Osterloh

Pirkle

et al. 2003

Environ Health Perspect

119

View full text Add to dashboard Cite

The collapse of the World Trade Center (WTC) on 11 September 2001 exposed New York City firefighters to smoke and dust of unprecedented magnitude and duration. The chemicals and the concentrations produced from any fire are difficult to predict, but estimates of internal dose exposures can be assessed by the biological monitoring of blood and urine. We analyzed blood and urine specimens obtained from 321 firefighters responding to the WTC fires and collapse for 110 potentially fire-related chemicals. Controls consisted of 47 firefighters not present at the WTC. Sampling occurred 3 weeks after 11 September, while fires were still burning. When reference or background ranges were available, most chemical concentrations were found to be generally low and not outside these ranges. Compared with controls, the exposed firefighters showed significant differences in adjusted geometric means for six of the chemicals and significantly greater detection rates for an additional three. Arrival time was a significant predictor variable for four chemicals. Special Operations Command firefighters (n = 95), compared with other responding WTC firefighters (n = 226), had differences in concentrations or detection rate for 14 of the chemicals. Values for the Special Operations Command firefighters were also significantly different from the control group values for these same chemicals and for two additional chemicals. Generally, the chemical concentrations in the other firefighter group were not different from those of controls. Biomonitoring was used to characterize firefighter exposure at the WTC disaster. Although some of the chemicals analyzed showed statistically significant differences, these differences were generally small.

show abstract

Section: Discussionsupporting

confidence: 92%

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Edelman

Osterloh

Pirkle

et al. 2003

Environ Health Perspect

119

View full text Add to dashboard Cite

show abstract

“…In turn, Tepper et al (1997) found serum PCDD/F levels of 18.1 pg I-TEQ/g a Only nine workers showed 1-HP levels above the detection limit lipid (low exposure) and 21.2 pg I-TEQ/g lipid (high exposure) in pulp and paper mill workers compared with a concentration of 19.1 pg I-TEQ/g lipid for community residents. Recently, Kumagai et al (2000) did not ®nd signi®cant dierences in the serum mean concentrations of PCDD/Fs in Japanese MWI workers (19.2±28.8 pg I-TEQ/g lipid) and control subjects (22.9±24.5 pg I-TEQ/ g lipid).…”

Section: Discussionmentioning

confidence: 98%

Levels of metals and organic substances in blood and urine of workers at a new hazardous waste incinerator

Domingo¹,

Schuhmacher²,

Agramunt³

et al. 2001

International Archives of Occupational and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Average TEQ concentrations of t-PCDD/Fs in the blood samples of general population in Europe are 14-43 pg I-TEQ/g lipid, 19-27 pg I-TEQ/g lipid in North America, 20-22 pg I-TEQ/g lipid in Japan 33) . Twelve PCB isomer concentrations are calculated as TEQ calculated by I-TEFs suggested by WHO in 1997 34) .…”

Section: Exposure Assessment Of Pcdd/fs Homologue In Residents Near Tmentioning

confidence: 99%

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

et al. 2003

View full text Add to dashboard Cite

Hazardous substances, such as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) also have been detected in Municipal Solid Waste (MSW)and industrial waste incinerators in Korea. In this study, we estimated the exposure status of these hazardous substances and their heath effects in workers and residents near the MSW incinerators and residents near the industrial waste incinerators. We interviewed 13 workers and 16 residents from the area around the two MSW incinerators, and further 10 residents from the area around one industrial waste incinerator, which is suspected to emit higher hazardous substances. During the interview we collected information including sociodemographic information, personal habits, work history, detailed gynecologic and other medical history. Blood samples from 45 subjects were also collected for analysis of PCDDs and PCDFs, which were analyzed by HRGC-HRMS (High Resolution Gas Chromatography -High Resolution Mass Spectrometer). In addition to a questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. Urinary concentrations of 8-OH-dG were determined by in vitro ELISA (JAICA, Fukuroi, Japan). MDA were determined by HPLC using adduct with TBA (thiobarbituric acid). The PCDD/F concentrations in residents from the area around industrial waste incinerator were higher than those in workers and residents from the area around MSW incinerator. The average toxic equivalency (TEQ) concentrations of PCDD/Fs in residents from the area around industrial waste incinerator were 53.4 pg I-TEQs/g lipid. The average TEQ concentrations of PCDD/Fs in workers and residents near MSW incinerator were 12.2 pg I-TEQs/g lipid. Estimated daily intake (EDI) of each person was calculated, and the EDI of all workers and residents near MSW incinerator were within the tolerable daily intake range. But for only 30% of 10 people near the industrial waste incinerator were the EDI within the tolerable daily intake range (1-4 pg I-TEQ/kg bw/day) suggested by WHO (1997). The oxidative stress of residents near the industrial waste incinerator was higher than that in workers and residents from the area around MSW incinerator. This oxidative stress may have been caused by hazardous substances, such as PCDD/Fs emitted by incinerators. The residents from the area around industrial waste incinerator were exposed to hazardous substances such as PCDD/ Fs. Proper protection strategies against these hazardous chemicals are needed.

show abstract

Polychlorinated dibenzo-p-dioxin and dibenzofuran concentrations in the serum samples of workers at continuously burning municipal waste incinerators in Japan

Cited by 51 publications

References 25 publications

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Levels of metals and organic substances in blood and urine of workers at a new hazardous waste incinerator

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

Contact Info

Product

Resources

About