Polychlorodibenzo-<i>p</i>-dioxins: Perinatal Effects and the Dominant Lethal Test in Wistar Rats

Khera, K. S.; Ruddick, Joseph A.

doi:10.1021/ba-1973-0120.ch008

Cited by 72 publications

(19 citation statements)

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“…The high mortality among yolk sac fry is partly associated with the inability of tail-born fry to free themselves from the egg shells, but to a much higher degree with the occurrence of generalized edemas. Edema formation is a consistent feature of TCDDpoisoning (Khera and Ruddick, 1973;Schwetz et al, 1973;Vos et al, 1973). Also the presence of hydropericardium and degenerative changes of bloodvessels are in concordance with previous reports, concerning animals fed with fat~ontaining TCDD (Allen, 1964;Allen and Carstens, 1967).…”

Section: Discussionsupporting

confidence: 84%

“…It produces chloracne in man and rabbits (Kimmig and Schulz, 1957;Jones and Krizek, 1962) and causes several pathologic changes in the liver of different species (Gupta et al, 1973;Jones and Butler, 1974;Vos et al, 1974). Edemas were reported in chickens (Schwetz et al, 1973), in mice (Vos et al, 1974) and in rat fetuses after maternal treatment (Khera and Ruddick, 1973).…”

Section: Introductionmentioning

confidence: 99%

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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on early life stages of the pike (Esox lucius L.)

Helder

1980

Science of The Total Environment

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Freshly fertilized pike eggs were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at concentrations of 0.1, 1.0 and 10 ppt (ng/liter) for 96 hours. At all concentrations examined egg development was retarded by 23%, and the growth of fry was also significantly retarded for a long period after exposure. A dose-related mortality was observed. Highest mortality rates occurred during resorption of the yolk and reached almost 100 percent at a concentration of 10 ppt. Death was preceded by development of severe generalized edemas.Histopathologically edemas and hemorrhages were observed, together with alterations of bloodvessel walls. In the liver, two stages of pathological changes were distinguished. The first was characterized by a dilation of sinusoids and a slight swelling of hepatocyte nuclei; in the second stage the nuclei were enlarged up to twice the normal diameter. Hepatocytes were degenerated and varied in size and shape and liver architecture was a almost completely lost.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on early life stages of the pike (Esox lucius L.)

Helder

1980

Science of The Total Environment

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“…Dogs appear to be less sensitive than rabbits. Others have reported 100%o mortality in rabbits treated with 10 pxg/kg (15) and chick embryos treated with 0.05 pg/egg (5 800 ,ug/kg-day (16).…”

Section: Discussion and Summarymentioning

confidence: 99%

“…OCDD and 2,7-DCDD caused neither teratogenicity nor embryotoxicity at 100 mg/kg-day. Khera and Ruddick (16) reported that the administration of 2 mg 2,7-DCDD/kg-day was associated with microscopic myocardial and pericardial lesions in rat fetuses. However, examination of sections of myocardium and pericardium from fetuses of dams treated with 100 mg doses in this study revealed no morphological differences from controls.…”

Section: Discussion and Summarymentioning

confidence: 99%

Toxicology of Chlorinated Dibenzo-p-Dioxins

Schwetz¹,

Norris²,

Sparschu³

et al. 1973

Environmental Health Perspectives

117

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“…However, polycyclic aromatic hydrocarbons are substrates for CYP1A1 and exposure to these molecules correlates with low birth weights in humans and in other species (Khera et al, 1972;Allen and Barsotti, 1976;Shum et al, 1979;Wong et al, 1985). An implication is that placental metabolism regulates nutrient delivery to the fetus.…”

Section: Evidence For Placental Control Of Permeability and Metabolismmentioning

confidence: 99%

Controlling drug delivery across the placenta

Audus

1999

European Journal of Pharmaceutical Sciences

106

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Abstract:A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either mother or fetus. There is evidence emerging that indicates the placenta does express natural transport and metabolism processes that function to control drug and nutrient distribution between the mother and fetus. Further, in vitro techniques developed in the past ten years now provide some of the tools necessary to elucidate transport and metabolism processes typical of the human placenta. As a consequence, pharmaceutical scientists are in a position to contribute significantly to the design and development of drugs for pregnancy. Controlling drug delivery across the placenta: A commentary. Eur. J. Pharm. Sci. 8, 161-165. PMID: 10379038. Publisher's official version: http://dx

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Polychlorodibenzo-p-dioxins: Perinatal Effects and the Dominant Lethal Test in Wistar Rats

Cited by 72 publications

References 0 publications

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on early life stages of the pike (Esox lucius L.)

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on early life stages of the pike (Esox lucius L.)

Toxicology of Chlorinated Dibenzo-p-Dioxins

Controlling drug delivery across the placenta

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