Polychromatic X-ray in-line phase-contrast tomography for soft tissue

Guo, Xuejun; Liu, Xiaolin; Gu, Ming; Ni, Chen; Huang, Shiming; Liu, Bo

doi:10.1209/0295-5075/98/14001

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…One way is to reduce the size of the focal spot in the x-ray tube such that a high coherence is achieved. These kinds of devices are called microfocus tubes and first results are described in [13,30]. The second method is based on conventional x-ray tubes that are modified by special gratings.…”

Section: Introductionmentioning

confidence: 99%

Cone beam geometry for small objects in phase contrast tomography

Jonas¹,

Louis²

2013

Inverse Problems

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Phase contrast tomography has developed rapidly within the last ten years. The new method enables the reconstruction of the refraction index in addition to the attenuation coefficient and can therefore be very well applied to samples which are only weakly absorbing. First studies in phase contract tomography were done using synchrotron devices which are modeled by the so-called parallel geometry. Samples studied so far are special foams and fiber materials, see Cloetens et al (1999 App. Phys. Lett. 75 2912-4), which give almost no contrast due to absorption but provide excellent images in phase contrast. Recently tubes were successfully applied to a variety of applications. These laboratory devices no longer fulfil the requirement of a parallel geometry but need to be treated as a fan/cone beam geometry. In this paper we derive a mathematical model for cone beam geometry in phase contrast tomography in two and three dimensions for objects small compared to the two distances of object to detector and x-ray source to object. All approximations needed are analyzed and an efficient reconstruction method providing both phase and absorption in a single step is derived, based on the method by Louis and Maaß (1990 Inverse Problems 6 427-39). The reconstruction method is successfully tested using numerical examples with simulated phantom data.

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Section: Introductionmentioning

confidence: 99%

Cone beam geometry for small objects in phase contrast tomography

Jonas¹,

Louis²

2013

Inverse Problems

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“…In addition, in-line PC-CT is a useful imaging technique due to its relatively simple set up. It does not require any crystals or additional equipment besides a high-intensity high-energy monochromatic beam and a detector (Guo et al, 2012).…”

Section: Background Information 21 Phase-contrast Ctmentioning

confidence: 99%

Assessment of freeware programs for the reconstruction of tomography datasets obtained with a monochromatic synchrotron-based X-ray source

Wolkowski

Snead

Wesolowski

et al. 2015

J Synchrotron Radiat

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Synchrotron-based in-line phase-contrast computed tomography (PC-CT) allows soft tissue to be imaged with sub-gross resolution and has potential to be used as a diagnostic tool. The reconstruction and processing of in-line PC-CT datasets is a computationally demanding task; thus, an efficient and user-friendly software program is desirable. Four freeware programs (NRecon, PITRE, H-PITRE and Athabasca Recon) were compared for the availability of features such as dark-and flat-field calibration, beam power normalization, ring artifact removal, and alignment tools for optimizing image quality. An in-line PC-CT projection dataset (3751 projections, 180 rotation, 10.13 mm Â 0.54 mm) was collected from a formalin-fixed canine prostate at the Biomedical Imaging and Therapy Bending Magnet (BMIT-BM) beamline of the Canadian Light Source. This dataset was processed with each of the four software programs and usability of the program was evaluated. Efficiency was assessed by how each program maximized computer processing power during computation. Athabasca Recon had the least-efficient memory usage, least user-friendly interface, and lacked a ring artifact removal feature. NRecon, PITRE and H-PITRE produced similar quality images, but the Athabasca Recon reconstruction suffered from the lack of a native ring remover algorithm. The 64-bit version of NRecon uses GPU (graphics processor unit) memory for accelerated processing and is userfriendly, but does not provide necessary parameters for in-line PC-CT data, such as dark-field and flat-field correction and beam power normalization. PITRE has many helpful features and tools, but lacks a comprehensive user manual and help section. H-PITRE is a condensed version of PITRE and maximizes computer memory for efficiency. To conclude, NRecon has fewer imaging processing tools than PITRE and H-PITRE, but is ideal for less experienced users due to a simple user interface. Based on the quality of reconstructed images, efficient use of computer memory and parameter availability, H-PITRE was the preferred of the four programs compared.

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“…[24][25][26] The PAD-based method has been applied in various studies to generate and evaluate phase sensitive images. [27][28][29][30][31][32][33] The details of the PAD-based retrieval method can be found in the supplementary information (SI).…”

Section: Introductionmentioning

confidence: 99%

“…One of the single distance phase retrieval methods which is based on the phase attenuation duality principle (PAD), is well suited for clinical imaging 24–26 . The PAD‐based method has been applied in various studies to generate and evaluate phase sensitive images 27–33 . The details of the PAD‐based retrieval method can be found in the (SI).…”

Section: Introductionmentioning

confidence: 99%

Development and preclinical evaluation of a patient‐specific high energy x‐ray phase sensitive breast tomosynthesis system

Ghani

Fajardo

et al. 2021

Medical Physics

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Background: This article reports the first x-ray phase sensitive breast tomosynthesis (PBT) system that is aimed for direct translation to clinical practice for the diagnosis of breast cancer. Purpose: To report the preclinical evaluation and comparison of the newly built PBT system with a conventional digital breast tomosynthesis (DBT) system. Methods and materials: The PBT system is developed based on a comprehensive inline phase contrast theoretical model. The system consists of a polyenergetic microfocus x-ray source and a flat panel detector mounted on an arm that is attached to a rotating gantry. It acquires nine projections over a 15°angular span in a stop-and-shoot manner. A dedicated phase retrieval algorithm is integrated with a filtered back-projection method that reconstructs tomographic slices. The American College of Radiology (ACR) accreditation phantom, a contrast detail (CD) phantom and mastectomy tissue samples were imaged at the same glandular dose levels by both the PBT and a standard of care DBT system for image quality characterizations and comparisons. Results: The PBT imaging scores with the ACR phantom are in good to excellent range and meet the quality assurance criteria set by the Mammography Quality Standard Act. The CD phantom image comparison and associated statistical analyses from two-alternative forced-choice reader studies confirm the improvement offered by the PBT system in terms of contrast resolution, spatial resolution, and conspicuity. The artifact spread function (ASF) analyses revealed a sizable lateral spread of metal artifacts in PBT slices as compared to DBT slices. Signal-to-noise ratio values for various inserts of the ACR and CD phantoms further validated the superiority of the PBT system. Mastectomy sample images acquired by the PBT system showed a superior depiction of microcalcifications vs the DBT system. Conclusion:The PBT imaging technology can be clinically employed for improving the accuracy of breast cancer screening and diagnosis.

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Polychromatic X-ray in-line phase-contrast tomography for soft tissue

Cited by 12 publications

References 29 publications

Cone beam geometry for small objects in phase contrast tomography

Cone beam geometry for small objects in phase contrast tomography

Assessment of freeware programs for the reconstruction of tomography datasets obtained with a monochromatic synchrotron-based X-ray source

Development and preclinical evaluation of a patient‐specific high energy x‐ray phase sensitive breast tomosynthesis system

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