Polyclonal activators in pulmonary immune disease

Wf, Willoughby; Jb, Willoughby; Gf, Gerberick

doi:10.1007/bf02992983

Cited by 7 publications

(2 citation statements)

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“…The patho genesis of this and other lung diseases induced by organic dusts is not clearly understood. Recently, Willoughby et al [2] proposed a hypothesis for the mechanism of lung disease induction by organic dusts. According to the proposed concept, dusts that induce lung inflammation contain polyclonal cell ac tivators (PCAs) capable of affecting several cell types.…”

Section: Introductionmentioning

confidence: 99%

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Cotton Bract Tannin: A Novel Human T-Lymphocyte Mitogen and a Possible Causative Agent of Byssinosis

Vuk-Pavlović

Russell

Rohrbach

1988

Int Arch Allergy Immunol

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Cotton bract tannin, a major organic component of cotton dust, was tested for mitogenic activity upon human T lymphocytes. Tannin caused polyclonal activation of human T lymphocytes in vitro. The pattern of T-cell response to tannin was similar to the pattern seen in lymphocytes stimulated with the well-known plant lectin T-cell mitogens, PHA and ConA. The response to tannin was shown to be dependent upon tannin dose and presence of monocytes. The maximum response occurred after 3–4 days in culture with the magnitude comparable to the one achieved by ConA. Lipopolysaccharide from Enterobacter agglomerans, a major contaminant of cotton dust, was shown not to be a mediator of tannin mitogenicity in vitro. A role for tannin as a polyclonal cell activator and, therefore, a possible etiologic agent of byssinosis is suggested by these observations.

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Section: Introductionmentioning

confidence: 99%

“…Together with transudation of plasma these events lead to a full inflammatory response [2], Tannins are condensed polyphenols which comprise about 5% of water-soluble cotton dust components [3]. Earlier studies from this laboratory have shown that tannin exhibits many biological effects.…”

Section: Introductionmentioning

confidence: 99%