2024
DOI: 10.21203/rs.3.rs-4904329/v1
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Polycomb protein Bmi1 promotes odontoblast differentiation by accelerating Wnt and BMP signaling pathways

Akihiro Hosoya,
Hiroaki Takebe,
Yuri Kishimoto
et al.

Abstract: Bmi1 is a polycomb protein localized in stem cells and maintains their stemness ability. This protein is also reported to regulate the expression of various differentiation genes. In this study, to analyze the role of Bmi1 during dentinogenesis, we examined the immunohistochemical localization of Bmi1 during rat tooth development as well as after cavity preparation. Bmi1 localization was hardly detected in the dental mesenchyme at the bud and cap stages. After the bell stage, however, this protein became detec… Show more

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