Polycyclic aromatic hydrocarbon coated onto Fe2O3 particles: assessment of cellular membrane damage and antioxidant system disruption in human epithelial lung cells (L132) in culture

Garçon, Guillaume; Shirali, Pirouz; Garry, Sébastien; Fontaine, Monique; Zerimech, Farid; Martin, Annie; Hannothiaux, Marie‐Hélène

doi:10.1016/s0378-4274(00)00231-9

Cited by 32 publications

(24 citation statements)

References 36 publications

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“…For example, benzo[a]pyrene in culture caused free radical-induced cell membrane damage, and the effect was enhanced by iron oxide (Garcon et al 2000). Also, native DEP and organic extracts of DEP were more potent than the stripped DEP in activating nuclear factor-κB and protein kinases (Bonvallot et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Effects of submicrometer particle compositions on cytokine production and lipid peroxidation of human bronchial epithelial cells.

Huang¹,

Hsu²,

Chan³

2003

Environ Health Perspect

109

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To identify the size and components related to toxicity of ambient particles, we used a trichotomous impactor to collect 17 sets of particles in three size ranges--submicrometer (diameters < 1 microm; PM1.0, fine (diameters between 1 and 2.5 microm; PM1.0-2.5, and coarse (diameters between 2.5 and 10 microm; PM2.5-10--at stations monitoring background, urban, traffic, and industrial air in Taiwan. Elemental contents, carbon contents, soluble ions, and endotoxin content of particles were determined by X-ray fluorescence spectrometry, thermal analysis, ion chromatography, and the Limulus amebocyte lysate assay, respectively. Human bronchial epithelial BEAS-2B cells were exposed to particle extracts at 100 micro g/mL for 8 hr, and interleukin-8 (IL-8) concentrations in the medium and lipid peroxidation products were measured. Particle-induced tumor necrosis factor-alpha (TNF-alpha) production by mouse macrophage RAW 264.7 cells was also measured. PM1.0 stimulation resulted in significantly higher IL-8 production and lipid peroxidation than PM2.5-10, whereas the responses elicited by PM1.0-2.5 were not significantly higher than blank filters. Untreated and polymyxin B-pretreated PM1.0 also stimulated more TNF-alpha production by RAW 264.7 cells than PM2.5-10 and PM1.0-2.5. Cytokine production was significantly associated with metal contents of PM1.0: IL-8 correlated with Cr and Mn, and TNF-alpha correlated with Fe and Cr. Lipid peroxidation in BEAS-2B cells correlated with elemental and organic carbon contents. Our study found that size and composition of ambient particles were both important factors in inducing cytokine production and lipid peroxidation.

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Section: Discussionmentioning

confidence: 99%

Effects of submicrometer particle compositions on cytokine production and lipid peroxidation of human bronchial epithelial cells.

Huang¹,

Hsu²,

Chan³

2003

Environ Health Perspect

109

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“…Iron impurities in fossil fuels convert on combustion to magnetic iron oxides, i.e., magnetite, hematite or a mixture of both. Due to its combustion origin, magnetic PM is not only dangerous in itself (Phumala et al, 1999;Garcon et al, 2000;, but is also associated with other hazardous pollutants which are injected into the atmosphere during combustion (Morris et al, 1995;Muxworthy et al, 2001). PM in vehicle exhaust is dominated by particles < 10 μm, i.e., PM 10 (Kim et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Magnetic signature of daily sampled urban atmospheric particles

Muxworthy

Matzka

Dávila

et al. 2003

Atmospheric Environment

104

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The magnetic signature of two sets of daily-sampled particulate matter (PM) collected in Munich, Germany, were examined and compared to variations in other pollution data and meteorological data using principal component analysis. The magnetic signature arising from the magnetic minerals in the PM, was examined using a fast and highly sensitive magnetic remanence measurement. The longest data set studied was 160 days, significantly longer than that of similar magnetic PM studies improving the statistical robustness. It was found that the variations in the mass dependent magnetic parameters displayed a complicated relationship governed by both the meteorological conditions and the PM loading rate, whereas mineralogy/grain-size dependent magnetic parameters displayed little variation. A six-fold increase in the number of vehicles passing the sampling locations only doubled the magnetic remanence of the samples, suggesting that the measured magnetic signature is in addition strongly influenced by dispersion rates. At both localities the saturation isothermal remanent magnetisation (SIRM) was found to be strongly correlated with the PM mass, and it is suggested that measuring SIRM as a proxy for PM monitoring is a viable alternative to magnetic susceptibility when the samples are magnetically too weak. The signal was found to be dominated by magnetite-like grains less than 100 nm in diameter which is thought to be derived primarily from vehicles. Such small grains are known to be particularly dangerous to humans. There was also evidence to suggest from magnetic stability parameters that the magnetite-like grains were covered with an oxidised rim. The concentration of magnetic particulate matter was in the range of 0.3-0.5% by mass.

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“…Eisenoxidpartikel besitzen darüber hinaus adsorptive Eigenschaften und können die Toxizität, die Aufnahme und den Metabolismus adsorbierter Stoffe infolge Kombinationswirkung beeinflussen (u. a. Cheu et al 1996;Garcon et al 2000;Haguenoer et al1996 (Kawamura et al 1990). …”

Section: Analytische Bestimmung (Verfahrenshinweise)unclassified

Eisenoxide (einatembare Fraktion) [MAK Value Documentation in German language, 2011]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 51. Lieferung, Ausgabe 2011 Der Artikel enthält folgende Kapitel: Allgemeine Charakterisierung Vorkommen Lagerstätten und Hauptförderländer Herstellung und Verwendung Rohstoffe Herstellungs‐ und Verarbeitungsprozess Herstellung synthetischer Eisenoxide (Pigmente) Verwendungsgebiete ― Eisenoxide Messverfahren Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Polycyclic aromatic hydrocarbon coated onto Fe2O3 particles: assessment of cellular membrane damage and antioxidant system disruption in human epithelial lung cells (L132) in culture

Cited by 32 publications

References 36 publications

Effects of submicrometer particle compositions on cytokine production and lipid peroxidation of human bronchial epithelial cells.

Effects of submicrometer particle compositions on cytokine production and lipid peroxidation of human bronchial epithelial cells.

Magnetic signature of daily sampled urban atmospheric particles

Eisenoxide (einatembare Fraktion) [MAK Value Documentation in German language, 2011]

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