Polycyclic aromatic hydrocarbon exposure results in altered CRH, reproductive, and thyroid hormone concentrations during human pregnancy

Association of exposure to polycyclic aromatic hydrocarbons with thyroid hormones in adolescents and adults, and the influence of the iodine status

“…The PROTECT longitudinal birth cohort research previously also observed a signicant positive association between exposure to PAHs and T3 in pregnant women. 8 Using human cell-based gene assays, a previous in vitro experiment found that diesel exhaust particulate related organic pollutants such as PAHs and their derivatives activated thyroid receptor a (TRa) and signicantly enhanced the activity of the endogenous TRa ligand, triiodothyronine. 43 Additionally, we discovered that lower FT4 levels were signicantly associated with higher concentration of 9-FLU in adolescents, and the higher concentration of 2-FLU and 9-FLU in male adolescent subgroups.…”

“…4 Human exposure occurs mostly through ingestion, inhalation, and skin contact, which includes smoking, high-temperature cooking, vehicle emissions, asphalt particles, mining, metalworking, generator use, power station pollution, volcanic outbreaks, insecticides and bushre. 7,8 Humans quickly convert absorbed PAHs into hydroxylated metabolites, most of which are excreted out of the body through urine. 9,10 Thus, the hydroxylated metabolites of urinary PAHs (OH-PAHs) are reliable indicators of PAH exposure.…”

“…4 Exposure to PAHs may have been linked to jaundice, kidney and liver damage, reduced lung function, cataracts, and skin inammation and redness. 4,8,19,20 What's more, some studies reported that exposure to PAHs had negative effects on the development of children and disturbed the hormone system. 4,21 In humans, one of the most essential endocrine glands is the thyroid.…”

Wildfire Smoke Exposure during Pregnancy: A Review of Potential Mechanisms of Placental Toxicity, Impact on Obstetric Outcomes, and Strategies to Reduce Exposure

“…These alterations in thyroid hormone levels led to a 56 g decrease in mean birth weight in this birth cohort of over 400 mother-infant pairs. Thyroid function alterations have also been reported among pregnant cohort of 659 women in Puerto Rico exposed to PAHs in addition to alterations in estriol, progesterone, and testosterone [ 101 ].…”

Molecular DFT Investigation on the Inclusion Complexation of Benzo[a]pyrene with γ-Cyclodextrin

“…[1,2] They are ubiquitous pollutants of major concern because of their significant toxicity to humans, [3][4][5] ecotoxicity, carcinogenicity, mutagenicity and effects on reproductive ability. [6][7][8][9] Benzo [a]pyrene is a byproduct of incomplete combustion or pyrolysis of organic materials; [6,10] it was characterized and identified at the beginning of the 1930s when Cook, Hewett and Heiger succeeded to synthesize it. [11] The crystalline form of BaP was originally reported by John Iball in 1936, [12] and already at that time its acute toxicity and high carcinogenicity were well known.…”